RNF19A | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	33 studies	34% ± 13%	Explore
B cell	28 studies	26% ± 10%	Explore
natural killer cell	26 studies	26% ± 10%	Explore
T cell	24 studies	29% ± 10%	Explore
CD8-positive, alpha-beta T cell	24 studies	27% ± 8%	Explore
CD4-positive, alpha-beta T cell	23 studies	27% ± 8%	Explore
regulatory T cell	21 studies	33% ± 10%	Explore
fibroblast	18 studies	26% ± 6%	Explore
astrocyte	15 studies	41% ± 18%	Explore
mature NK T cell	15 studies	26% ± 10%	Explore
gamma-delta T cell	15 studies	27% ± 10%	Explore
memory B cell	14 studies	22% ± 5%	Explore
ciliated cell	13 studies	28% ± 16%	Explore
naive B cell	13 studies	23% ± 6%	Explore
CD16-positive, CD56-dim natural killer cell, human	13 studies	25% ± 9%	Explore
mucosal invariant T cell	13 studies	26% ± 8%	Explore
CD16-negative, CD56-bright natural killer cell, human	12 studies	24% ± 9%	Explore
capillary endothelial cell	12 studies	23% ± 6%	Explore
smooth muscle cell	11 studies	23% ± 5%	Explore
CD8-positive, alpha-beta memory T cell	10 studies	34% ± 10%	Explore
effector memory CD8-positive, alpha-beta T cell	10 studies	34% ± 14%	Explore
endothelial cell of artery	10 studies	20% ± 4%	Explore
pericyte	9 studies	25% ± 6%	Explore
type I pneumocyte	9 studies	32% ± 9%	Explore
CD4-positive, alpha-beta memory T cell	9 studies	26% ± 9%	Explore
glutamatergic neuron	9 studies	41% ± 24%	Explore
epithelial cell	9 studies	33% ± 19%	Explore
adipocyte	9 studies	36% ± 10%	Explore
macrophage	9 studies	24% ± 8%	Explore
endothelial cell of lymphatic vessel	8 studies	23% ± 6%	Explore
GABAergic neuron	8 studies	39% ± 20%	Explore
myeloid cell	7 studies	24% ± 9%	Explore
basal cell	7 studies	29% ± 11%	Explore
club cell	7 studies	26% ± 5%	Explore
T follicular helper cell	7 studies	41% ± 15%	Explore
secretory cell	6 studies	25% ± 10%	Explore
leukocyte	6 studies	32% ± 11%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	6 studies	29% ± 9%	Explore
microglial cell	6 studies	23% ± 5%	Explore
endothelial cell of vascular tree	6 studies	26% ± 15%	Explore
oligodendrocyte precursor cell	6 studies	25% ± 9%	Explore
mast cell	5 studies	20% ± 5%	Explore
monocyte	5 studies	23% ± 5%	Explore
effector CD8-positive, alpha-beta T cell	5 studies	30% ± 11%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	5 studies	29% ± 11%	Explore
neuron	5 studies	38% ± 18%	Explore
retina horizontal cell	5 studies	29% ± 10%	Explore
cardiac muscle cell	5 studies	31% ± 8%	Explore
dendritic cell	5 studies	23% ± 7%	Explore
lymphocyte	5 studies	38% ± 18%	Explore
Mueller cell	5 studies	25% ± 7%	Explore
respiratory goblet cell	5 studies	29% ± 9%	Explore
innate lymphoid cell	5 studies	22% ± 10%	Explore
type II pneumocyte	5 studies	23% ± 3%	Explore
erythrocyte	5 studies	44% ± 22%	Explore
interneuron	5 studies	43% ± 21%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	27% ± 11%	Explore
squamous epithelial cell	4 studies	33% ± 22%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	27% ± 7%	Explore
non-classical monocyte	4 studies	24% ± 7%	Explore
vein endothelial cell	4 studies	28% ± 17%	Explore
retinal ganglion cell	4 studies	34% ± 10%	Explore
plasma cell	4 studies	27% ± 8%	Explore
retinal cone cell	4 studies	22% ± 7%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	31% ± 12%	Explore
abnormal cell	4 studies	31% ± 10%	Explore
myofibroblast cell	4 studies	24% ± 3%	Explore
oligodendrocyte	4 studies	28% ± 4%	Explore
double negative thymocyte	4 studies	31% ± 11%	Explore
classical monocyte	3 studies	25% ± 5%	Explore
exhausted T cell	3 studies	50% ± 14%	Explore
plasmablast	3 studies	34% ± 8%	Explore
GABAergic interneuron	3 studies	20% ± 3%	Explore
precursor B cell	3 studies	17% ± 1%	Explore
CD4-positive helper T cell	3 studies	42% ± 11%	Explore
cholangiocyte	3 studies	61% ± 11%	Explore
hepatocyte	3 studies	56% ± 26%	Explore
pancreatic ductal cell	3 studies	52% ± 26%	Explore
connective tissue cell	3 studies	22% ± 3%	Explore
ependymal cell	3 studies	46% ± 8%	Explore
adventitial cell	3 studies	30% ± 4%	Explore
alveolar macrophage	3 studies	27% ± 7%	Explore
group 3 innate lymphoid cell	3 studies	34% ± 12%	Explore
goblet cell	3 studies	37% ± 28%	Explore
T-helper 17 cell	3 studies	31% ± 9%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	16% ± 1%	Explore
renal principal cell	3 studies	36% ± 4%	Explore
mural cell	3 studies	38% ± 15%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	14 studies	31% ± 17%	Explore
lung	11 studies	26% ± 9%	Explore
peripheral blood	9 studies	25% ± 9%	Explore
eye	5 studies	22% ± 8%	Explore
kidney	5 studies	21% ± 4%	Explore
liver	5 studies	30% ± 10%	Explore
intestine	4 studies	20% ± 1%	Explore
heart	4 studies	26% ± 5%	Explore
adipose	4 studies	34% ± 12%	Explore
uterus	3 studies	30% ± 10%	Explore
lymph node	3 studies	22% ± 1%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	4195.32	1445 / 1445	100%	43.89	183 / 183
lung	100%	6572.61	578 / 578	100%	46.70	1152 / 1155
breast	100%	5129.19	459 / 459	100%	58.35	1113 / 1118
brain	100%	2860.04	2629 / 2642	99%	70.61	701 / 705
pancreas	100%	2467.18	328 / 328	99%	37.09	176 / 178
bladder	100%	5589.38	21 / 21	98%	39.51	494 / 504
uterus	100%	6173.25	170 / 170	98%	37.86	449 / 459
kidney	100%	4122.53	89 / 89	97%	38.02	874 / 901
ovary	100%	4882.55	180 / 180	97%	28.56	417 / 430
stomach	100%	3836.84	359 / 359	97%	28.65	277 / 286
prostate	100%	4207.51	245 / 245	96%	25.98	481 / 502
thymus	100%	3926.60	652 / 653	96%	22.01	579 / 605
intestine	100%	5300.62	966 / 966	95%	24.89	503 / 527
skin	100%	5070.12	1809 / 1809	93%	34.94	440 / 472
liver	100%	2542.89	226 / 226	93%	31.09	376 / 406
adrenal gland	100%	2266.64	258 / 258	87%	19.84	199 / 230
adipose	100%	5887.86	1204 / 1204	0%	0	0 / 0
blood vessel	100%	5444.80	1335 / 1335	0%	0	0 / 0
spleen	100%	4744.07	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	45.66	45 / 45
ureter	0%	0	0 / 0	100%	53.74	1 / 1
muscle	100%	3089.37	802 / 803	0%	0	0 / 0
heart	99%	2908.84	850 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	93%	39.63	27 / 29
peripheral blood	82%	3819.39	763 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	49%	9.21	39 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006511	Biological process	ubiquitin-dependent protein catabolic process
GO_0099576	Biological process	regulation of protein catabolic process at postsynapse, modulating synaptic transmission
GO_0000209	Biological process	protein polyubiquitination
GO_0000226	Biological process	microtubule cytoskeleton organization
GO_0098978	Cellular component	glutamatergic synapse
GO_0005813	Cellular component	centrosome
GO_0000151	Cellular component	ubiquitin ligase complex
GO_0005829	Cellular component	cytosol
GO_0098794	Cellular component	postsynapse
GO_0098686	Cellular component	hippocampal mossy fiber to CA3 synapse
GO_0016020	Cellular component	membrane
GO_0005737	Cellular component	cytoplasm
GO_0061630	Molecular function	ubiquitin protein ligase activity
GO_0005515	Molecular function	protein binding
GO_0008270	Molecular function	zinc ion binding
GO_0031624	Molecular function	ubiquitin conjugating enzyme binding

IV. Literature review

[source]

Gene name	RNF19A
Protein name	Ring finger protein 19A, RBR E3 ubiquitin protein ligase RING finger protein 19 isoform (Ring finger protein 19A, RBR E3 ubiquitin protein ligase) RNF19A protein E3 ubiquitin-protein ligase RNF19A (EC 2.3.2.31) (Double ring-finger protein) (Dorfin) (RING finger protein 19A) (p38) Alternative protein RNF19A
Synonyms	RNF19
Description	FUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as SNCAIP or CASR. Specifically ubiquitinates pathogenic SOD1 variants, which leads to their proteasomal degradation and to neuronal protection. .
Accessions	E7EQV8 E7EQ63 Q3MHC3 ENST00000517584.5 A0A0C4DGD6 ENST00000523481.5 ENST00000523167.1 L8E8P4 Q3ZCS9 ENST00000519527.5 E5RJH6 ENST00000341084.7 [Q9NV58-1] ENST00000519449.5 [Q9NV58-1] ENST00000432381.2 ENST00000522369.5 Q9NV58 A3KCU8 E7ETB2

RNF19A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review