RIPOR2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	43 studies	44% ± 17%	Explore
natural killer cell	30 studies	39% ± 14%	Explore
CD4-positive, alpha-beta T cell	26 studies	41% ± 17%	Explore
classical monocyte	23 studies	35% ± 15%	Explore
non-classical monocyte	23 studies	45% ± 14%	Explore
T cell	21 studies	35% ± 15%	Explore
CD8-positive, alpha-beta T cell	21 studies	40% ± 16%	Explore
naive B cell	19 studies	46% ± 11%	Explore
regulatory T cell	19 studies	38% ± 17%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	18 studies	53% ± 16%	Explore
memory B cell	17 studies	52% ± 14%	Explore
monocyte	16 studies	31% ± 14%	Explore
ciliated cell	16 studies	34% ± 17%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	15 studies	49% ± 14%	Explore
plasmacytoid dendritic cell	15 studies	33% ± 9%	Explore
gamma-delta T cell	14 studies	39% ± 17%	Explore
mature NK T cell	14 studies	35% ± 14%	Explore
mucosal invariant T cell	14 studies	41% ± 16%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	48% ± 9%	Explore
dendritic cell	13 studies	33% ± 19%	Explore
CD16-negative, CD56-bright natural killer cell, human	13 studies	45% ± 16%	Explore
neutrophil	12 studies	46% ± 15%	Explore
conventional dendritic cell	11 studies	28% ± 20%	Explore
platelet	11 studies	42% ± 18%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	40% ± 12%	Explore
effector memory CD8-positive, alpha-beta T cell	10 studies	52% ± 16%	Explore
GABAergic neuron	9 studies	48% ± 22%	Explore
glutamatergic neuron	9 studies	34% ± 17%	Explore
CD8-positive, alpha-beta memory T cell	9 studies	37% ± 13%	Explore
endothelial cell	8 studies	33% ± 21%	Explore
astrocyte	7 studies	32% ± 13%	Explore
innate lymphoid cell	6 studies	50% ± 22%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	29% ± 10%	Explore
precursor B cell	6 studies	39% ± 10%	Explore
interneuron	6 studies	52% ± 25%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	41% ± 20%	Explore
plasmablast	5 studies	29% ± 11%	Explore
effector CD4-positive, alpha-beta T cell	5 studies	39% ± 16%	Explore
lymphocyte	5 studies	47% ± 25%	Explore
immature B cell	5 studies	51% ± 10%	Explore
mast cell	5 studies	30% ± 9%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	53% ± 16%	Explore
central memory CD8-positive, alpha-beta T cell	4 studies	47% ± 18%	Explore
T follicular helper cell	4 studies	32% ± 20%	Explore
double negative thymocyte	4 studies	51% ± 20%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	23% ± 2%	Explore
plasma cell	3 studies	29% ± 12%	Explore
exhausted T cell	3 studies	35% ± 19%	Explore
megakaryocyte	3 studies	55% ± 13%	Explore
pro-B cell	3 studies	31% ± 8%	Explore
GABAergic amacrine cell	3 studies	20% ± 3%	Explore
germinal center B cell	3 studies	34% ± 6%	Explore
intermediate monocyte	3 studies	64% ± 16%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	64% ± 2%	Explore
hematopoietic stem cell	3 studies	31% ± 13%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	18 studies	44% ± 12%	Explore
brain	9 studies	28% ± 17%	Explore
lung	4 studies	22% ± 4%	Explore
bone marrow	3 studies	34% ± 13%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	99%	4263.22	575 / 578	68%	4.65	789 / 1155
brain	79%	1568.21	2080 / 2642	85%	6.15	597 / 705
breast	95%	1522.68	436 / 459	55%	3.39	610 / 1118
prostate	93%	1547.76	229 / 245	53%	4.09	266 / 502
skin	58%	709.55	1050 / 1809	83%	12.63	392 / 472
uterus	99%	8624.97	169 / 170	36%	2.34	163 / 459
thymus	56%	614.04	368 / 653	74%	8.05	450 / 605
kidney	52%	481.58	46 / 89	73%	5.21	654 / 901
bladder	81%	965.71	17 / 21	33%	1.92	164 / 504
intestine	70%	1434.55	676 / 966	30%	1.81	160 / 527
lymph node	0%	0	0 / 0	100%	44.42	29 / 29
peripheral blood	100%	35485.70	929 / 929	0%	0	0 / 0
spleen	100%	11903.15	241 / 241	0%	0	0 / 0
adipose	98%	1543.01	1181 / 1204	0%	0	0 / 0
muscle	97%	2394.74	777 / 803	0%	0	0 / 0
ovary	45%	469.53	81 / 180	45%	1.99	195 / 430
adrenal gland	30%	245.20	78 / 258	57%	3.34	132 / 230
eye	0%	0	0 / 0	86%	10.32	69 / 80
stomach	41%	338.86	148 / 359	43%	2.05	122 / 286
tonsil	0%	0	0 / 0	67%	4.08	30 / 45
pancreas	2%	10.37	5 / 328	51%	3.36	90 / 178
esophagus	23%	186.94	333 / 1445	29%	1.47	53 / 183
liver	28%	219.33	63 / 226	12%	0.70	48 / 406
blood vessel	38%	379.12	502 / 1335	0%	0	0 / 0
heart	19%	174.56	166 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0035024	Biological process	negative regulation of Rho protein signal transduction
GO_0007605	Biological process	sensory perception of sound
GO_2000114	Biological process	regulation of establishment of cell polarity
GO_1903904	Biological process	negative regulation of establishment of T cell polarity
GO_0007162	Biological process	negative regulation of cell adhesion
GO_0045663	Biological process	positive regulation of myoblast differentiation
GO_0006935	Biological process	chemotaxis
GO_0007155	Biological process	cell adhesion
GO_2001107	Biological process	negative regulation of Rho guanyl-nucleotide exchange factor activity
GO_2000405	Biological process	negative regulation of T cell migration
GO_1901741	Biological process	positive regulation of myoblast fusion
GO_1905872	Biological process	negative regulation of protein localization to cell leading edge
GO_0051491	Biological process	positive regulation of filopodium assembly
GO_0030154	Biological process	cell differentiation
GO_0007517	Biological process	muscle organ development
GO_0090023	Biological process	positive regulation of neutrophil chemotaxis
GO_1990869	Biological process	cellular response to chemokine
GO_2000391	Biological process	positive regulation of neutrophil extravasation
GO_0016324	Cellular component	apical plasma membrane
GO_0032420	Cellular component	stereocilium
GO_0005856	Cellular component	cytoskeleton
GO_0060171	Cellular component	stereocilium membrane
GO_0030175	Cellular component	filopodium
GO_0005737	Cellular component	cytoplasm
GO_0071889	Molecular function	14-3-3 protein binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	RIPOR2
Protein name	RHO family interacting cell polarization regulator 2 Rho family-interacting cell polarization regulator 2
Synonyms	C6orf32 FAM65B DIFF48 KIAA0386 PL48
Description	FUNCTION: Acts as an inhibitor of the small GTPase RHOA and plays several roles in the regulation of myoblast and hair cell differentiation, lymphocyte T proliferation and neutrophil polarization . Inhibits chemokine-induced T lymphocyte responses, such as cell adhesion, polarization and migration . Involved also in the regulation of neutrophil polarization, chemotaxis and adhesion (By similarity). Required for normal development of inner and outer hair cell stereocilia within the cochlea of the inner ear (By similarity). Plays a role for maintaining the structural organization of the basal domain of stereocilia (By similarity). Involved in mechanosensory hair cell function (By similarity). Required for normal hearing . .; FUNCTION: [Isoform 2]: Acts as an inhibitor of the small GTPase RHOA . Plays a role in fetal mononuclear myoblast differentiation by promoting filopodia and myotube formation . Maintains naive T lymphocytes in a quiescent state . .
Accessions	ENST00000647136.1 ENST00000645703.1 ENST00000644621.1 [Q9Y4F9-2] ENST00000644411.1 A0A2R8Y4N2 A0A2R8YF77 A0A2R8Y4B9 ENST00000259698.9 [Q9Y4F9-1] ENST00000378023.8 [Q9Y4F9-2] A0A2R8Y7B3 ENST00000643898.2 B7Z6U4 F5H029 ENST00000540914.5 ENST00000613507.4 [Q9Y4F9-1] A0A2R8YEE0 ENST00000645100.1 ENST00000510784.8 ENST00000538035.6 ENST00000647309.1 Q9Y4F9 F5GX51 ENST00000643623.1 [Q9Y4F9-2]

RIPOR2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review