PTPN1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	33 studies	36% ± 10%	Explore
macrophage	25 studies	25% ± 11%	Explore
dendritic cell	21 studies	42% ± 20%	Explore
memory B cell	20 studies	39% ± 12%	Explore
classical monocyte	20 studies	23% ± 9%	Explore
regulatory T cell	20 studies	22% ± 5%	Explore
plasmacytoid dendritic cell	19 studies	35% ± 10%	Explore
non-classical monocyte	19 studies	28% ± 11%	Explore
natural killer cell	18 studies	22% ± 6%	Explore
endothelial cell	17 studies	27% ± 11%	Explore
conventional dendritic cell	17 studies	28% ± 12%	Explore
naive B cell	17 studies	30% ± 10%	Explore
plasma cell	15 studies	34% ± 14%	Explore
CD4-positive, alpha-beta T cell	15 studies	25% ± 5%	Explore
monocyte	14 studies	30% ± 9%	Explore
CD8-positive, alpha-beta T cell	14 studies	22% ± 5%	Explore
T cell	13 studies	23% ± 8%	Explore
gamma-delta T cell	13 studies	24% ± 7%	Explore
CD16-positive, CD56-dim natural killer cell, human	12 studies	24% ± 5%	Explore
CD16-negative, CD56-bright natural killer cell, human	12 studies	21% ± 4%	Explore
mast cell	11 studies	27% ± 6%	Explore
type I pneumocyte	11 studies	47% ± 14%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	11 studies	23% ± 7%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	11 studies	21% ± 7%	Explore
mucosal invariant T cell	11 studies	24% ± 6%	Explore
type II pneumocyte	10 studies	30% ± 10%	Explore
CD8-positive, alpha-beta memory T cell	10 studies	25% ± 5%	Explore
effector memory CD8-positive, alpha-beta T cell	10 studies	23% ± 6%	Explore
myeloid cell	10 studies	32% ± 8%	Explore
fibroblast	10 studies	26% ± 8%	Explore
pericyte	9 studies	30% ± 10%	Explore
mature NK T cell	9 studies	22% ± 4%	Explore
smooth muscle cell	8 studies	24% ± 6%	Explore
plasmablast	8 studies	38% ± 18%	Explore
CD4-positive, alpha-beta memory T cell	8 studies	23% ± 6%	Explore
epithelial cell	8 studies	32% ± 14%	Explore
leukocyte	7 studies	25% ± 4%	Explore
microglial cell	7 studies	24% ± 6%	Explore
mononuclear phagocyte	6 studies	24% ± 7%	Explore
effector CD8-positive, alpha-beta T cell	5 studies	20% ± 4%	Explore
innate lymphoid cell	5 studies	20% ± 3%	Explore
glutamatergic neuron	5 studies	48% ± 24%	Explore
oligodendrocyte	5 studies	24% ± 6%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	20% ± 4%	Explore
precursor B cell	4 studies	28% ± 4%	Explore
immature B cell	4 studies	25% ± 7%	Explore
cardiac muscle cell	4 studies	21% ± 1%	Explore
ciliated cell	4 studies	28% ± 9%	Explore
lymphocyte	4 studies	34% ± 11%	Explore
IgG plasma cell	4 studies	24% ± 7%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	28% ± 7%	Explore
granulocyte	4 studies	29% ± 15%	Explore
GABAergic neuron	4 studies	44% ± 14%	Explore
astrocyte	4 studies	28% ± 6%	Explore
club cell	4 studies	29% ± 3%	Explore
vein endothelial cell	4 studies	22% ± 9%	Explore
T follicular helper cell	4 studies	23% ± 4%	Explore
interneuron	4 studies	36% ± 22%	Explore
hematopoietic precursor cell	3 studies	39% ± 17%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	22% ± 2%	Explore
IgA plasma cell	3 studies	32% ± 10%	Explore
muscle cell	3 studies	31% ± 12%	Explore
oligodendrocyte precursor cell	3 studies	27% ± 6%	Explore
connective tissue cell	3 studies	26% ± 7%	Explore
alveolar macrophage	3 studies	30% ± 10%	Explore
basal cell	3 studies	36% ± 17%	Explore
goblet cell	3 studies	30% ± 20%	Explore
neuron	3 studies	28% ± 8%	Explore
T-helper 1 cell	3 studies	19% ± 2%	Explore
double negative thymocyte	3 studies	30% ± 8%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	13 studies	27% ± 7%	Explore
lung	9 studies	27% ± 7%	Explore
brain	8 studies	34% ± 17%	Explore
bone marrow	3 studies	25% ± 3%	Explore
kidney	3 studies	18% ± 2%	Explore
lymph node	3 studies	18% ± 1%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	4243.36	1445 / 1445	100%	71.16	183 / 183
prostate	100%	4536.47	245 / 245	100%	59.78	502 / 502
skin	100%	4270.98	1809 / 1809	100%	108.78	472 / 472
stomach	100%	3032.04	359 / 359	100%	62.07	286 / 286
lung	100%	9827.06	578 / 578	100%	74.86	1154 / 1155
breast	100%	4117.44	459 / 459	100%	105.20	1117 / 1118
kidney	100%	7362.89	89 / 89	100%	74.71	897 / 901
intestine	100%	4387.70	966 / 966	99%	60.49	524 / 527
bladder	100%	3939.57	21 / 21	99%	58.39	501 / 504
uterus	100%	4320.79	170 / 170	99%	61.42	456 / 459
ovary	100%	4319.52	180 / 180	99%	42.76	427 / 430
thymus	100%	3573.13	652 / 653	99%	42.24	597 / 605
adrenal gland	100%	4953.22	258 / 258	98%	41.44	225 / 230
brain	98%	1735.41	2582 / 2642	100%	43.54	704 / 705
liver	100%	1945.12	226 / 226	93%	26.53	378 / 406
pancreas	94%	1343.27	308 / 328	98%	55.38	175 / 178
adipose	100%	4429.51	1204 / 1204	0%	0	0 / 0
blood vessel	100%	4984.30	1335 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	100%	52.99	80 / 80
lymph node	0%	0	0 / 0	100%	231.96	29 / 29
spleen	100%	7934.88	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	76.14	45 / 45
ureter	0%	0	0 / 0	100%	26.35	1 / 1
muscle	100%	3623.84	800 / 803	0%	0	0 / 0
peripheral blood	99%	6476.52	922 / 929	0%	0	0 / 0
heart	98%	3318.90	842 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0043507	Biological process	positive regulation of JUN kinase activity
GO_0009966	Biological process	regulation of signal transduction
GO_0034620	Biological process	cellular response to unfolded protein
GO_0006470	Biological process	protein dephosphorylation
GO_0033157	Biological process	regulation of intracellular protein transport
GO_0060338	Biological process	regulation of type I interferon-mediated signaling pathway
GO_1902236	Biological process	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO_0009968	Biological process	negative regulation of signal transduction
GO_0060397	Biological process	growth hormone receptor signaling pathway via JAK-STAT
GO_1903896	Biological process	positive regulation of IRE1-mediated unfolded protein response
GO_0038020	Biological process	insulin receptor recycling
GO_0070373	Biological process	negative regulation of ERK1 and ERK2 cascade
GO_0030948	Biological process	negative regulation of vascular endothelial growth factor receptor signaling pathway
GO_0035335	Biological process	peptidyl-tyrosine dephosphorylation
GO_0046627	Biological process	negative regulation of insulin receptor signaling pathway
GO_1902202	Biological process	regulation of hepatocyte growth factor receptor signaling pathway
GO_0035791	Biological process	platelet-derived growth factor receptor-beta signaling pathway
GO_0030968	Biological process	endoplasmic reticulum unfolded protein response
GO_2000646	Biological process	positive regulation of receptor catabolic process
GO_0030036	Biological process	actin cytoskeleton organization
GO_0008286	Biological process	insulin receptor signaling pathway
GO_0036498	Biological process	IRE1-mediated unfolded protein response
GO_1903898	Biological process	negative regulation of PERK-mediated unfolded protein response
GO_0030100	Biological process	regulation of endocytosis
GO_0043407	Biological process	negative regulation of MAP kinase activity
GO_1990264	Biological process	peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity
GO_0061098	Biological process	positive regulation of protein tyrosine kinase activity
GO_0005886	Cellular component	plasma membrane
GO_0030061	Cellular component	mitochondrial crista
GO_0005769	Cellular component	early endosome
GO_0032991	Cellular component	protein-containing complex
GO_0098554	Cellular component	cytoplasmic side of endoplasmic reticulum membrane
GO_0097443	Cellular component	sorting endosome
GO_0005783	Cellular component	endoplasmic reticulum
GO_0005829	Cellular component	cytosol
GO_0005759	Cellular component	mitochondrial matrix
GO_0005737	Cellular component	cytoplasm
GO_0031904	Cellular component	endosome lumen
GO_0004726	Molecular function	non-membrane spanning protein tyrosine phosphatase activity
GO_0019899	Molecular function	enzyme binding
GO_0005158	Molecular function	insulin receptor binding
GO_0051721	Molecular function	protein phosphatase 2A binding
GO_0046875	Molecular function	ephrin receptor binding
GO_0045296	Molecular function	cadherin binding
GO_0019901	Molecular function	protein kinase binding
GO_0008270	Molecular function	zinc ion binding
GO_0003723	Molecular function	RNA binding
GO_0005515	Molecular function	protein binding
GO_0030971	Molecular function	receptor tyrosine kinase binding
GO_0004725	Molecular function	protein tyrosine phosphatase activity

IV. Literature review

[source]

Gene name	PTPN1
Protein name	Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B) Tyrosine-protein phosphatase non-receptor type (EC 3.1.3.48)
Synonyms	hCG_37134 PTP1B
Description	FUNCTION: Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET. .
Accessions	ENST00000371621.5 B4DSN5 A8K3M3 ENST00000541713.5 P18031

PTPN1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review