PSMB8 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0019882Biological processantigen processing and presentation
GO_0052548Biological processregulation of endopeptidase activity
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0045444Biological processfat cell differentiation
GO_0000502Cellular componentproteasome complex
GO_0070062Cellular componentextracellular exosome
GO_0005839Cellular componentproteasome core complex
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0019774Cellular componentproteasome core complex, beta-subunit complex
GO_1990111Cellular componentspermatoproteasome complex
GO_0005634Cellular componentnucleus
GO_0004175Molecular functionendopeptidase activity
GO_0005515Molecular functionprotein binding
GO_0004298Molecular functionthreonine-type endopeptidase activity

IV. Literature review

[source]
Gene namePSMB8
Protein nameProteasome subunit beta
Proteasome subunit beta type-8 (EC 3.4.25.1) (Low molecular mass protein 7) (Macropain subunit C13) (Multicatalytic endopeptidase complex subunit C13) (Proteasome component C13) (Proteasome subunit beta-5i) (Really interesting new gene 10 protein)
Proteasome subunit beta type-8
Proteasome 20S subunit beta 8 (Proteasome subunit beta type-8)
SynonymsLMP7
Y2
PSM8
RING10
PSMB5i
DescriptionFUNCTION: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Replacement of PSMB5 by PSMB8 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues. Involved in the generation of spliced peptides resulting from the ligation of two separate proteasomal cleavage products that are not contiguous in the parental protein . Acts as a major component of interferon gamma-induced sensitivity. Plays a key role in apoptosis via the degradation of the apoptotic inhibitor MCL1. May be involved in the inflammatory response pathway. In cancer cells, substitution of isoform 1 (E2) by isoform 2 (E1) results in immunoproteasome deficiency. Required for the differentiation of preadipocytes into adipocytes. .

FUNCTION: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. .

FUNCTION: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. .

AccessionsENST00000425784.6
P28062
ENST00000452573.2 [P28062-2]
ENST00000438442.6 [P28062-1]
ENST00000421445.6 [P28062-1]
A0A140T998
ENST00000455660.6 [P28062-1]
ENST00000436627.2 [P28062-2]
ENST00000374881.3 [P28062-2]
ENST00000416564.2 [P28062-2]
ENST00000427919.6
ENST00000441960.6 [P28062-2]
ENST00000446762.6
ENST00000435978.6 [P28062-2]
ENST00000416134.2 [P28062-2]
ENST00000458543.2
ENST00000374882.8 [P28062-1]
ENST00000429645.6 [P28062-1]
ENST00000395339.7
Q5JNW7
ENST00000383236.8 [P28062-1]
X5D2R7
ENST00000399630.7
ENST00000449883.2
ENST00000446855.6
ENST00000457261.6 [P28062-1]
ENST00000383238.4 [P28062-2]
Q6FHU0
ENST00000447073.6