PSMA6 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0050727Biological processregulation of inflammatory response
GO_0051092Biological processpositive regulation of NF-kappaB transcription factor activity
GO_0051603Biological processproteolysis involved in protein catabolic process
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0000502Cellular componentproteasome complex
GO_0019773Cellular componentproteasome core complex, alpha-subunit complex
GO_0005840Cellular componentribosome
GO_0030016Cellular componentmyofibril
GO_0070062Cellular componentextracellular exosome
GO_0005634Cellular componentnucleus
GO_0005654Cellular componentnucleoplasm
GO_0000932Cellular componentP-body
GO_0016363Cellular componentnuclear matrix
GO_0030017Cellular componentsarcomere
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005839Cellular componentproteasome core complex
GO_0004175Molecular functionendopeptidase activity
GO_0003723Molecular functionRNA binding
GO_0035639Molecular functionpurine ribonucleoside triphosphate binding
GO_0005515Molecular functionprotein binding
GO_0051059Molecular functionNF-kappaB binding

IV. Literature review

[source]
Gene namePSMA6
Protein nameProteasome subunit alpha type-6 (27 kDa prosomal protein) (PROS-27) (p27K) (Macropain iota chain) (Multicatalytic endopeptidase complex iota chain) (Proteasome iota chain)
Prosomal P27K protein
Proteasome 20S subunit alpha 6
Proteasome subunit alpha type
SynonymsPROS27
DescriptionFUNCTION: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). .

AccessionsENST00000261479.9 [P60900-1]
ENST00000554961.5
ENST00000556506.1
ENST00000622405.4 [P60900-3]
G3V3I1
ENST00000553688.5
ENST00000554620.5
G3V4S5
H0YJC4
ENST00000555764.5 [P60900-3]
ENST00000556221.1
ENST00000554541.5
ENST00000553809.5
G3V5Z7
P60900
ENST00000628955.1
ENST00000540871.5 [P60900-2]
ENST00000627895.2
Q9BZ93
G3V3U4
G3V2S7
G3V295