PSMA1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
fibroblast	34 studies	33% ± 15%	Explore
endothelial cell	32 studies	33% ± 15%	Explore
CD4-positive, alpha-beta T cell	29 studies	33% ± 16%	Explore
natural killer cell	28 studies	32% ± 11%	Explore
T cell	27 studies	30% ± 12%	Explore
macrophage	27 studies	31% ± 14%	Explore
CD8-positive, alpha-beta T cell	26 studies	35% ± 16%	Explore
B cell	25 studies	28% ± 11%	Explore
smooth muscle cell	22 studies	33% ± 12%	Explore
conventional dendritic cell	21 studies	39% ± 17%	Explore
classical monocyte	20 studies	31% ± 14%	Explore
pericyte	20 studies	33% ± 12%	Explore
regulatory T cell	20 studies	32% ± 15%	Explore
non-classical monocyte	18 studies	31% ± 14%	Explore
mast cell	17 studies	29% ± 12%	Explore
monocyte	17 studies	32% ± 11%	Explore
epithelial cell	17 studies	37% ± 20%	Explore
basal cell	16 studies	35% ± 17%	Explore
mature NK T cell	15 studies	27% ± 8%	Explore
gamma-delta T cell	15 studies	29% ± 15%	Explore
dendritic cell	14 studies	39% ± 22%	Explore
endothelial cell of lymphatic vessel	14 studies	34% ± 13%	Explore
capillary endothelial cell	14 studies	27% ± 6%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	13 studies	29% ± 7%	Explore
myofibroblast cell	13 studies	32% ± 14%	Explore
connective tissue cell	13 studies	38% ± 15%	Explore
microglial cell	13 studies	39% ± 15%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	12 studies	34% ± 11%	Explore
naive B cell	11 studies	22% ± 5%	Explore
plasmacytoid dendritic cell	11 studies	36% ± 9%	Explore
myeloid cell	11 studies	33% ± 13%	Explore
plasma cell	10 studies	35% ± 15%	Explore
CD16-negative, CD56-bright natural killer cell, human	10 studies	28% ± 10%	Explore
CD16-positive, CD56-dim natural killer cell, human	10 studies	31% ± 9%	Explore
vein endothelial cell	10 studies	28% ± 9%	Explore
memory B cell	10 studies	24% ± 7%	Explore
mucosal invariant T cell	10 studies	27% ± 7%	Explore
ciliated cell	10 studies	38% ± 14%	Explore
effector memory CD8-positive, alpha-beta T cell	9 studies	28% ± 12%	Explore
progenitor cell	9 studies	37% ± 15%	Explore
endothelial cell of artery	9 studies	29% ± 8%	Explore
endothelial cell of vascular tree	9 studies	34% ± 8%	Explore
adipocyte	9 studies	50% ± 14%	Explore
leukocyte	8 studies	34% ± 9%	Explore
secretory cell	8 studies	32% ± 13%	Explore
alveolar macrophage	7 studies	26% ± 7%	Explore
plasmablast	7 studies	47% ± 21%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	31% ± 16%	Explore
abnormal cell	7 studies	33% ± 11%	Explore
goblet cell	7 studies	28% ± 13%	Explore
CD8-positive, alpha-beta memory T cell	7 studies	36% ± 16%	Explore
type I pneumocyte	6 studies	28% ± 13%	Explore
epithelial cell of proximal tubule	6 studies	28% ± 8%	Explore
enterocyte	6 studies	22% ± 7%	Explore
astrocyte	6 studies	37% ± 14%	Explore
oligodendrocyte precursor cell	6 studies	33% ± 8%	Explore
T follicular helper cell	6 studies	25% ± 3%	Explore
CD4-positive, alpha-beta memory T cell	6 studies	41% ± 16%	Explore
hematopoietic precursor cell	5 studies	52% ± 27%	Explore
kidney loop of Henle epithelial cell	5 studies	24% ± 2%	Explore
mesothelial cell	5 studies	48% ± 19%	Explore
transit amplifying cell	5 studies	23% ± 3%	Explore
lymphocyte	5 studies	32% ± 14%	Explore
innate lymphoid cell	5 studies	28% ± 4%	Explore
erythrocyte	5 studies	32% ± 18%	Explore
neuron	5 studies	40% ± 22%	Explore
effector CD4-positive, alpha-beta T cell	5 studies	37% ± 22%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	42% ± 21%	Explore
mononuclear phagocyte	4 studies	41% ± 18%	Explore
glutamatergic neuron	4 studies	44% ± 24%	Explore
exhausted T cell	4 studies	44% ± 18%	Explore
enteroendocrine cell	4 studies	41% ± 14%	Explore
intestinal crypt stem cell	4 studies	31% ± 9%	Explore
retinal ganglion cell	4 studies	60% ± 28%	Explore
hematopoietic stem cell	4 studies	43% ± 4%	Explore
precursor B cell	4 studies	32% ± 14%	Explore
retina horizontal cell	4 studies	30% ± 15%	Explore
type II pneumocyte	4 studies	34% ± 20%	Explore
hepatocyte	4 studies	47% ± 23%	Explore
granulocyte	4 studies	38% ± 13%	Explore
GABAergic neuron	4 studies	40% ± 23%	Explore
T-helper 17 cell	4 studies	43% ± 23%	Explore
immature B cell	4 studies	34% ± 22%	Explore
pancreatic A cell	3 studies	53% ± 21%	Explore
pancreatic D cell	3 studies	54% ± 25%	Explore
type B pancreatic cell	3 studies	53% ± 26%	Explore
glomerular endothelial cell	3 studies	27% ± 2%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	49% ± 15%	Explore
renal alpha-intercalated cell	3 studies	39% ± 13%	Explore
neural crest cell	3 studies	47% ± 7%	Explore
extravillous trophoblast	3 studies	46% ± 12%	Explore
placental villous trophoblast	3 studies	78% ± 9%	Explore
erythroblast	3 studies	54% ± 20%	Explore
megakaryocyte	3 studies	24% ± 8%	Explore
pro-B cell	3 studies	36% ± 6%	Explore
club cell	3 studies	36% ± 1%	Explore
amacrine cell	3 studies	36% ± 11%	Explore
retinal pigment epithelial cell	3 studies	34% ± 19%	Explore
adventitial cell	3 studies	33% ± 8%	Explore
mucus secreting cell	3 studies	21% ± 4%	Explore
intraepithelial lymphocyte	3 studies	30% ± 10%	Explore
Mueller cell	3 studies	28% ± 6%	Explore
neutrophil	3 studies	21% ± 5%	Explore
intermediate monocyte	3 studies	36% ± 26%	Explore
luminal hormone-sensing cell of mammary gland	3 studies	25% ± 8%	Explore
granulocyte monocyte progenitor cell	3 studies	51% ± 25%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	51% ± 25%	Explore
CD4-positive helper T cell	3 studies	23% ± 9%	Explore
glial cell	3 studies	35% ± 26%	Explore
group 3 innate lymphoid cell	3 studies	39% ± 14%	Explore
T-helper 1 cell	3 studies	46% ± 20%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	24% ± 3%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	22% ± 7%	Explore
central memory CD8-positive, alpha-beta T cell	3 studies	21% ± 4%	Explore
interneuron	3 studies	52% ± 21%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	14 studies	36% ± 14%	Explore
peripheral blood	14 studies	33% ± 12%	Explore
intestine	11 studies	28% ± 14%	Explore
brain	9 studies	32% ± 18%	Explore
kidney	8 studies	29% ± 10%	Explore
eye	7 studies	26% ± 11%	Explore
liver	6 studies	37% ± 22%	Explore
pancreas	4 studies	43% ± 26%	Explore
placenta	4 studies	48% ± 22%	Explore
bone marrow	4 studies	26% ± 6%	Explore
uterus	4 studies	39% ± 13%	Explore
lymph node	4 studies	29% ± 6%	Explore
adipose	4 studies	27% ± 13%	Explore
adrenal gland	3 studies	21% ± 6%	Explore
thymus	3 studies	49% ± 26%	Explore
prostate	3 studies	29% ± 10%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
bladder	100%	4943.24	21 / 21	100%	19.56	504 / 504
esophagus	100%	4646.67	1445 / 1445	100%	26.15	183 / 183
liver	100%	3718.54	226 / 226	100%	13.25	406 / 406
lung	100%	5475.96	578 / 578	100%	17.44	1155 / 1155
ovary	100%	3968.41	180 / 180	100%	20.97	430 / 430
stomach	100%	3806.07	359 / 359	100%	22.81	286 / 286
uterus	100%	4731.28	170 / 170	100%	19.60	459 / 459
thymus	100%	4635.12	653 / 653	100%	14.07	604 / 605
prostate	100%	4514.47	245 / 245	100%	16.00	501 / 502
kidney	100%	4223.82	89 / 89	100%	11.54	899 / 901
intestine	100%	4711.48	966 / 966	100%	21.28	525 / 527
breast	100%	5146.16	459 / 459	99%	15.57	1111 / 1118
brain	99%	3217.04	2621 / 2642	100%	11.91	705 / 705
adrenal gland	100%	5410.97	258 / 258	99%	12.97	228 / 230
skin	100%	5673.98	1809 / 1809	99%	13.44	467 / 472
pancreas	99%	2316.24	325 / 328	99%	15.12	177 / 178
adipose	100%	5525.48	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	26.61	29 / 29
muscle	100%	7017.56	803 / 803	0%	0	0 / 0
spleen	100%	5324.43	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	16.04	45 / 45
ureter	0%	0	0 / 0	100%	21.21	1 / 1
blood vessel	100%	5342.93	1334 / 1335	0%	0	0 / 0
heart	99%	4276.88	850 / 861	0%	0	0 / 0
peripheral blood	98%	4472.24	912 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	98%	11.32	78 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0002376	Biological process	immune system process
GO_0002862	Biological process	negative regulation of inflammatory response to antigenic stimulus
GO_0043161	Biological process	proteasome-mediated ubiquitin-dependent protein catabolic process
GO_0000502	Cellular component	proteasome complex
GO_0005813	Cellular component	centrosome
GO_0070062	Cellular component	extracellular exosome
GO_0005839	Cellular component	proteasome core complex
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0019773	Cellular component	proteasome core complex, alpha-subunit complex
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0001530	Molecular function	lipopolysaccharide binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	PSMA1
Protein name	Proteasome 20S subunit alpha 1 Proteasome subunit alpha type-1 (30 kDa prosomal protein) (PROS-30) (Macropain subunit C2) (Multicatalytic endopeptidase complex subunit C2) (Proteasome component C2) (Proteasome nu chain)
Synonyms	PSC2 NU HC2 PROS30
Description	FUNCTION: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). .
Accessions	ENST00000533068.5 P25786 F5GX11 ENST00000530457.5 F5H112 ENST00000396394.7 [P25786-1] ENST00000418988.2 [P25786-2]

PSMA1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review