PSIP1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	31 studies	29% ± 11%	Explore
endothelial cell	31 studies	30% ± 12%	Explore
CD4-positive, alpha-beta T cell	29 studies	30% ± 11%	Explore
CD8-positive, alpha-beta T cell	26 studies	27% ± 10%	Explore
natural killer cell	25 studies	27% ± 12%	Explore
fibroblast	25 studies	28% ± 11%	Explore
regulatory T cell	25 studies	31% ± 11%	Explore
T cell	22 studies	29% ± 9%	Explore
pericyte	21 studies	29% ± 11%	Explore
smooth muscle cell	18 studies	28% ± 9%	Explore
memory B cell	17 studies	28% ± 7%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	17 studies	34% ± 12%	Explore
naive B cell	17 studies	24% ± 6%	Explore
endothelial cell of lymphatic vessel	13 studies	23% ± 7%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	13 studies	34% ± 11%	Explore
mature NK T cell	13 studies	24% ± 7%	Explore
ciliated cell	13 studies	32% ± 12%	Explore
gamma-delta T cell	13 studies	31% ± 15%	Explore
myofibroblast cell	12 studies	31% ± 16%	Explore
CD8-positive, alpha-beta memory T cell	11 studies	30% ± 9%	Explore
glutamatergic neuron	11 studies	47% ± 21%	Explore
CD16-negative, CD56-bright natural killer cell, human	11 studies	29% ± 8%	Explore
oligodendrocyte precursor cell	11 studies	37% ± 16%	Explore
mucosal invariant T cell	11 studies	25% ± 6%	Explore
astrocyte	11 studies	32% ± 10%	Explore
CD16-positive, CD56-dim natural killer cell, human	10 studies	26% ± 6%	Explore
CD4-positive, alpha-beta memory T cell	10 studies	34% ± 11%	Explore
connective tissue cell	10 studies	33% ± 13%	Explore
endothelial cell of artery	10 studies	29% ± 5%	Explore
GABAergic neuron	9 studies	45% ± 23%	Explore
retinal rod cell	9 studies	44% ± 20%	Explore
oligodendrocyte	9 studies	35% ± 11%	Explore
effector memory CD8-positive, alpha-beta T cell	8 studies	31% ± 10%	Explore
neuron	8 studies	50% ± 20%	Explore
vein endothelial cell	8 studies	25% ± 7%	Explore
amacrine cell	8 studies	44% ± 23%	Explore
endothelial cell of vascular tree	8 studies	26% ± 8%	Explore
basal cell	7 studies	26% ± 7%	Explore
leukocyte	7 studies	25% ± 7%	Explore
capillary endothelial cell	7 studies	25% ± 6%	Explore
abnormal cell	7 studies	37% ± 14%	Explore
mesothelial cell	7 studies	32% ± 15%	Explore
interneuron	7 studies	50% ± 23%	Explore
epithelial cell	7 studies	36% ± 15%	Explore
T follicular helper cell	7 studies	33% ± 10%	Explore
microglial cell	6 studies	23% ± 4%	Explore
hematopoietic stem cell	6 studies	41% ± 18%	Explore
retina horizontal cell	6 studies	44% ± 21%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	37% ± 13%	Explore
hematopoietic precursor cell	5 studies	49% ± 19%	Explore
conventional dendritic cell	5 studies	37% ± 11%	Explore
progenitor cell	5 studies	25% ± 9%	Explore
retinal bipolar neuron	5 studies	45% ± 23%	Explore
OFF-bipolar cell	5 studies	31% ± 14%	Explore
ON-bipolar cell	5 studies	31% ± 16%	Explore
retinal ganglion cell	5 studies	39% ± 22%	Explore
lymphocyte	5 studies	29% ± 9%	Explore
pro-B cell	5 studies	47% ± 12%	Explore
retinal cone cell	5 studies	49% ± 23%	Explore
Mueller cell	5 studies	35% ± 12%	Explore
innate lymphoid cell	5 studies	26% ± 3%	Explore
CD4-positive helper T cell	4 studies	25% ± 5%	Explore
deuterosomal cell	4 studies	44% ± 4%	Explore
effector CD8-positive, alpha-beta T cell	4 studies	26% ± 3%	Explore
exhausted T cell	4 studies	25% ± 9%	Explore
granule cell	4 studies	30% ± 14%	Explore
GABAergic amacrine cell	4 studies	37% ± 15%	Explore
glycinergic amacrine cell	4 studies	33% ± 12%	Explore
immature B cell	4 studies	23% ± 7%	Explore
macrophage	4 studies	21% ± 5%	Explore
precursor B cell	4 studies	46% ± 18%	Explore
germinal center B cell	4 studies	35% ± 6%	Explore
megakaryocyte-erythroid progenitor cell	4 studies	60% ± 24%	Explore
T-helper 17 cell	4 studies	24% ± 7%	Explore
plasmacytoid dendritic cell	4 studies	21% ± 6%	Explore
plasmablast	3 studies	44% ± 4%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	26% ± 1%	Explore
non-classical monocyte	3 studies	31% ± 8%	Explore
glomerular endothelial cell	3 studies	22% ± 3%	Explore
neural crest cell	3 studies	63% ± 19%	Explore
GABAergic interneuron	3 studies	33% ± 5%	Explore
glial cell	3 studies	38% ± 25%	Explore
erythroblast	3 studies	59% ± 24%	Explore
myeloid cell	3 studies	21% ± 5%	Explore
plasma cell	3 studies	30% ± 11%	Explore
Schwann cell	3 studies	33% ± 18%	Explore
precursor cell	3 studies	47% ± 24%	Explore
rod bipolar cell	3 studies	59% ± 7%	Explore
dendritic cell	3 studies	40% ± 15%	Explore
neural progenitor cell	3 studies	45% ± 8%	Explore
intestinal crypt stem cell	3 studies	20% ± 4%	Explore
erythrocyte	3 studies	45% ± 12%	Explore
group 3 innate lymphoid cell	3 studies	42% ± 17%	Explore
transit amplifying cell	3 studies	35% ± 17%	Explore
goblet cell	3 studies	21% ± 4%	Explore
T-helper 1 cell	3 studies	29% ± 12%	Explore
enteroendocrine cell	3 studies	29% ± 11%	Explore
double negative thymocyte	3 studies	45% ± 13%	Explore
platelet	3 studies	18% ± 1%	Explore
secretory cell	3 studies	24% ± 7%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	15 studies	37% ± 19%	Explore
peripheral blood	14 studies	28% ± 8%	Explore
lung	10 studies	27% ± 10%	Explore
eye	10 studies	41% ± 16%	Explore
intestine	6 studies	27% ± 12%	Explore
bone marrow	4 studies	28% ± 12%	Explore
liver	4 studies	33% ± 21%	Explore
lymph node	4 studies	38% ± 17%	Explore
kidney	3 studies	19% ± 2%	Explore
uterus	3 studies	32% ± 9%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	9923.33	2642 / 2642	100%	98.69	705 / 705
ovary	100%	8245.81	180 / 180	100%	45.56	428 / 430
thymus	100%	4349.63	653 / 653	99%	48.04	601 / 605
uterus	100%	6865.98	170 / 170	98%	51.61	449 / 459
breast	100%	4006.95	459 / 459	97%	32.90	1089 / 1118
prostate	100%	4108.31	244 / 245	98%	22.43	490 / 502
lung	99%	3769.64	574 / 578	97%	27.14	1122 / 1155
esophagus	99%	4226.64	1424 / 1445	97%	28.23	178 / 183
intestine	100%	5069.28	965 / 966	94%	25.07	498 / 527
stomach	99%	3259.10	357 / 359	95%	26.59	271 / 286
adrenal gland	98%	2784.64	254 / 258	96%	51.72	220 / 230
kidney	100%	2927.36	89 / 89	93%	27.37	834 / 901
bladder	100%	4515.48	21 / 21	91%	26.18	458 / 504
skin	98%	3321.09	1771 / 1809	89%	28.43	418 / 472
pancreas	73%	1077.83	239 / 328	93%	20.50	166 / 178
liver	48%	663.06	108 / 226	67%	12.75	273 / 406
blood vessel	100%	6469.37	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	53.22	29 / 29
spleen	100%	4821.61	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	11.11	1 / 1
adipose	100%	4248.61	1200 / 1204	0%	0	0 / 0
tonsil	0%	0	0 / 0	96%	46.64	43 / 45
muscle	91%	1705.08	733 / 803	0%	0	0 / 0
heart	91%	2246.22	783 / 861	0%	0	0 / 0
peripheral blood	71%	5753.17	661 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	56%	8.29	45 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0000395	Biological process	mRNA 5'-splice site recognition
GO_0009408	Biological process	response to heat
GO_0006979	Biological process	response to oxidative stress
GO_0006338	Biological process	chromatin remodeling
GO_0000791	Cellular component	euchromatin
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0005634	Cellular component	nucleus
GO_0097100	Molecular function	supercoiled DNA binding
GO_0005515	Molecular function	protein binding
GO_0003723	Molecular function	RNA binding

IV. Literature review

[source]

Gene name	PSIP1
Protein name	PC4 and SFRS1-interacting protein (Lens epithelium-derived growth factor) PC4 and SRSF1 interacting protein 1 Alternative protein PSIP1 PC4 and SFRS1-interacting protein (CLL-associated antigen KW-7) (Dense fine speckles 70 kDa protein) (DFS 70) (Lens epithelium-derived growth factor) (Transcriptional coactivator p75/p52)
Synonyms	DFS70 LEDGF hCG_27254 PSIP2
Description	FUNCTION: Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration. .
Accessions	ENST00000380716.8 [O75475-2] ENST00000481862.1 L8E926 O75475 Q8N4N4 ENST00000380738.8 [O75475-1] ENST00000380715.5 [O75475-3] Q05CM9 ENST00000380733.9 [O75475-1] V9GYT7 ENST00000397519.6 [O75475-2]

PSIP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review