PRPF8 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	19 studies	25% ± 11%	Explore
plasmacytoid dendritic cell	16 studies	26% ± 7%	Explore
CD8-positive, alpha-beta T cell	16 studies	26% ± 5%	Explore
B cell	15 studies	24% ± 5%	Explore
natural killer cell	15 studies	26% ± 6%	Explore
regulatory T cell	15 studies	23% ± 5%	Explore
naive B cell	14 studies	23% ± 5%	Explore
CD4-positive, alpha-beta T cell	14 studies	25% ± 5%	Explore
T cell	13 studies	24% ± 6%	Explore
memory B cell	13 studies	24% ± 4%	Explore
fibroblast	12 studies	23% ± 6%	Explore
CD16-positive, CD56-dim natural killer cell, human	12 studies	24% ± 5%	Explore
ciliated cell	12 studies	29% ± 11%	Explore
gamma-delta T cell	12 studies	27% ± 10%	Explore
CD8-positive, alpha-beta memory T cell	11 studies	24% ± 5%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	11 studies	23% ± 5%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	11 studies	24% ± 5%	Explore
CD16-negative, CD56-bright natural killer cell, human	11 studies	23% ± 4%	Explore
macrophage	11 studies	22% ± 7%	Explore
classical monocyte	10 studies	22% ± 7%	Explore
mature NK T cell	10 studies	21% ± 3%	Explore
epithelial cell	9 studies	32% ± 13%	Explore
CD4-positive, alpha-beta memory T cell	8 studies	23% ± 4%	Explore
mucosal invariant T cell	8 studies	28% ± 7%	Explore
smooth muscle cell	7 studies	20% ± 2%	Explore
type I pneumocyte	7 studies	22% ± 6%	Explore
effector memory CD8-positive, alpha-beta T cell	7 studies	24% ± 5%	Explore
abnormal cell	7 studies	25% ± 6%	Explore
retinal rod cell	7 studies	26% ± 6%	Explore
pericyte	7 studies	19% ± 3%	Explore
basal cell	6 studies	29% ± 6%	Explore
conventional dendritic cell	6 studies	25% ± 11%	Explore
non-classical monocyte	6 studies	24% ± 10%	Explore
neuron	6 studies	24% ± 9%	Explore
myofibroblast cell	6 studies	20% ± 3%	Explore
retinal cone cell	6 studies	27% ± 7%	Explore
endothelial cell of lymphatic vessel	5 studies	18% ± 2%	Explore
effector CD8-positive, alpha-beta T cell	5 studies	21% ± 3%	Explore
oligodendrocyte precursor cell	5 studies	27% ± 9%	Explore
dendritic cell	5 studies	36% ± 17%	Explore
T follicular helper cell	5 studies	23% ± 3%	Explore
goblet cell	5 studies	25% ± 5%	Explore
hematopoietic precursor cell	4 studies	28% ± 9%	Explore
club cell	4 studies	21% ± 4%	Explore
secretory cell	4 studies	24% ± 2%	Explore
retinal bipolar neuron	4 studies	24% ± 6%	Explore
interneuron	4 studies	31% ± 17%	Explore
microglial cell	4 studies	28% ± 7%	Explore
progenitor cell	4 studies	20% ± 4%	Explore
hematopoietic stem cell	4 studies	19% ± 1%	Explore
lymphocyte	4 studies	24% ± 4%	Explore
precursor B cell	4 studies	24% ± 4%	Explore
pro-B cell	4 studies	28% ± 3%	Explore
myeloid cell	4 studies	25% ± 4%	Explore
retina horizontal cell	4 studies	19% ± 4%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	26% ± 7%	Explore
connective tissue cell	4 studies	18% ± 2%	Explore
monocyte	4 studies	18% ± 3%	Explore
astrocyte	4 studies	28% ± 8%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	19% ± 5%	Explore
ionocyte	3 studies	31% ± 5%	Explore
pancreatic A cell	3 studies	47% ± 22%	Explore
leukocyte	3 studies	20% ± 3%	Explore
exhausted T cell	3 studies	26% ± 3%	Explore
plasmablast	3 studies	33% ± 12%	Explore
amacrine cell	3 studies	25% ± 3%	Explore
retinal ganglion cell	3 studies	29% ± 11%	Explore
common myeloid progenitor	3 studies	24% ± 9%	Explore
immature B cell	3 studies	21% ± 1%	Explore
type II pneumocyte	3 studies	24% ± 5%	Explore
rod bipolar cell	3 studies	28% ± 5%	Explore
endothelial cell of vascular tree	3 studies	22% ± 2%	Explore
innate lymphoid cell	3 studies	21% ± 2%	Explore
granulocyte monocyte progenitor cell	3 studies	18% ± 1%	Explore
enteroendocrine cell	3 studies	26% ± 5%	Explore
erythrocyte	3 studies	28% ± 12%	Explore
group 3 innate lymphoid cell	3 studies	31% ± 11%	Explore
vein endothelial cell	3 studies	20% ± 6%	Explore
transit amplifying cell	3 studies	30% ± 9%	Explore
brush cell	3 studies	24% ± 6%	Explore
GABAergic neuron	3 studies	31% ± 11%	Explore
glutamatergic neuron	3 studies	34% ± 15%	Explore
oligodendrocyte	3 studies	23% ± 3%	Explore
double negative thymocyte	3 studies	34% ± 8%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	12 studies	25% ± 6%	Explore
lung	9 studies	19% ± 3%	Explore
eye	8 studies	25% ± 5%	Explore
brain	6 studies	27% ± 5%	Explore
bone marrow	4 studies	19% ± 3%	Explore
lymph node	4 studies	18% ± 1%	Explore
pancreas	3 studies	41% ± 20%	Explore
intestine	3 studies	22% ± 5%	Explore
liver	3 studies	27% ± 8%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	18281.54	1445 / 1445	100%	147.29	183 / 183
ovary	100%	30035.76	180 / 180	100%	87.50	430 / 430
prostate	100%	19122.13	245 / 245	100%	109.15	502 / 502
breast	100%	20398.08	459 / 459	100%	106.67	1116 / 1118
bladder	100%	22010.71	21 / 21	100%	82.02	503 / 504
uterus	100%	25859.96	170 / 170	100%	81.95	458 / 459
thymus	100%	21746.88	653 / 653	100%	100.76	603 / 605
intestine	100%	19688.76	966 / 966	100%	92.47	525 / 527
skin	100%	22237.77	1809 / 1809	100%	123.21	470 / 472
lung	100%	19988.59	578 / 578	99%	95.51	1149 / 1155
stomach	100%	14886.95	359 / 359	99%	103.42	284 / 286
pancreas	100%	9476.70	327 / 328	99%	67.14	176 / 178
kidney	100%	12342.96	89 / 89	99%	86.59	888 / 901
adrenal gland	100%	23545.10	258 / 258	97%	77.40	223 / 230
brain	97%	11938.08	2553 / 2642	100%	108.21	705 / 705
liver	99%	7645.24	224 / 226	93%	40.00	377 / 406
adipose	100%	18733.83	1204 / 1204	0%	0	0 / 0
blood vessel	100%	19408.31	1335 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	100%	107.38	80 / 80
lymph node	0%	0	0 / 0	100%	91.97	29 / 29
muscle	100%	23033.87	803 / 803	0%	0	0 / 0
spleen	100%	19464.43	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	106.28	45 / 45
ureter	0%	0	0 / 0	100%	18.32	1 / 1
heart	98%	12158.73	840 / 861	0%	0	0 / 0
peripheral blood	89%	12347.09	831 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006397	Biological process	mRNA processing
GO_0000244	Biological process	spliceosomal tri-snRNP complex assembly
GO_0000398	Biological process	mRNA splicing, via spliceosome
GO_0071356	Biological process	cellular response to tumor necrosis factor
GO_0008380	Biological process	RNA splicing
GO_0071222	Biological process	cellular response to lipopolysaccharide
GO_0000375	Biological process	RNA splicing, via transesterification reactions
GO_0046540	Cellular component	U4/U6 x U5 tri-snRNP complex
GO_0016020	Cellular component	membrane
GO_0016607	Cellular component	nuclear speck
GO_0005654	Cellular component	nucleoplasm
GO_0071007	Cellular component	U2-type catalytic step 2 spliceosome
GO_0071005	Cellular component	U2-type precatalytic spliceosome
GO_0071006	Cellular component	U2-type catalytic step 1 spliceosome
GO_0005682	Cellular component	U5 snRNP
GO_0071013	Cellular component	catalytic step 2 spliceosome
GO_0005634	Cellular component	nucleus
GO_0140492	Molecular function	metal-dependent deubiquitinase activity
GO_0008233	Molecular function	peptidase activity
GO_0030619	Molecular function	U1 snRNA binding
GO_0070530	Molecular function	K63-linked polyubiquitin modification-dependent protein binding
GO_0097157	Molecular function	pre-mRNA intronic binding
GO_0017070	Molecular function	U6 snRNA binding
GO_0030623	Molecular function	U5 snRNA binding
GO_0003723	Molecular function	RNA binding
GO_0030620	Molecular function	U2 snRNA binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	PRPF8
Protein name	Pre-mRNA-processing-splicing factor 8 (220 kDa U5 snRNP-specific protein) (PRP8 homolog) (Splicing factor Prp8) (p220) Pre-mRNA processing factor 8 (Pre-mRNA-processing-splicing factor 8) Pre-mRNA processing factor 8
Synonyms	PRPC8
Description	FUNCTION: Plays a role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes, both of the predominant U2-type spliceosome and the minor U12-type spliceosome . Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome. Functions as a scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5' and the 3' splice site. .
Accessions	A0A994J6E8 A0A994J6S8 ENST00000703537.1 ENST00000571958.1 I3L0J9 ENST00000577001.1 ENST00000614672.2 I3L3Z8 ENST00000573725.2 I3L1T8 A0A994J3N2 ENST00000304992.11 ENST00000634039.1 A0A994J491 ENST00000703538.1 ENST00000703540.1 ENST00000703541.1 ENST00000631647.1 Q6P2Q9 ENST00000572621.5

PRPF8 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review