PRPF6 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	15 studies	20% ± 4%	Explore
endothelial cell	15 studies	26% ± 8%	Explore
CD4-positive, alpha-beta T cell	14 studies	19% ± 3%	Explore
CD8-positive, alpha-beta T cell	14 studies	20% ± 5%	Explore
ciliated cell	13 studies	30% ± 13%	Explore
regulatory T cell	12 studies	19% ± 4%	Explore
B cell	11 studies	21% ± 3%	Explore
fibroblast	11 studies	22% ± 6%	Explore
gamma-delta T cell	11 studies	23% ± 10%	Explore
classical monocyte	10 studies	22% ± 6%	Explore
epithelial cell	9 studies	32% ± 17%	Explore
naive B cell	9 studies	18% ± 2%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	9 studies	21% ± 4%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	9 studies	21% ± 4%	Explore
CD16-negative, CD56-bright natural killer cell, human	9 studies	23% ± 4%	Explore
memory B cell	9 studies	20% ± 4%	Explore
pericyte	9 studies	21% ± 4%	Explore
T cell	8 studies	20% ± 3%	Explore
endothelial cell of lymphatic vessel	8 studies	20% ± 3%	Explore
CD16-positive, CD56-dim natural killer cell, human	8 studies	21% ± 4%	Explore
CD8-positive, alpha-beta memory T cell	8 studies	21% ± 3%	Explore
mucosal invariant T cell	8 studies	21% ± 3%	Explore
non-classical monocyte	7 studies	23% ± 6%	Explore
macrophage	7 studies	19% ± 4%	Explore
plasmacytoid dendritic cell	7 studies	23% ± 6%	Explore
mast cell	6 studies	23% ± 4%	Explore
smooth muscle cell	6 studies	26% ± 5%	Explore
CD4-positive, alpha-beta memory T cell	6 studies	20% ± 5%	Explore
basal cell	6 studies	29% ± 10%	Explore
mature NK T cell	6 studies	20% ± 4%	Explore
astrocyte	6 studies	22% ± 7%	Explore
abnormal cell	6 studies	23% ± 5%	Explore
secretory cell	5 studies	23% ± 12%	Explore
conventional dendritic cell	5 studies	26% ± 13%	Explore
effector memory CD8-positive, alpha-beta T cell	5 studies	22% ± 2%	Explore
connective tissue cell	5 studies	20% ± 4%	Explore
hematopoietic stem cell	5 studies	24% ± 5%	Explore
myofibroblast cell	5 studies	21% ± 3%	Explore
innate lymphoid cell	5 studies	27% ± 2%	Explore
neuron	5 studies	28% ± 13%	Explore
GABAergic neuron	5 studies	26% ± 11%	Explore
goblet cell	5 studies	25% ± 5%	Explore
hematopoietic precursor cell	4 studies	27% ± 11%	Explore
effector CD8-positive, alpha-beta T cell	4 studies	20% ± 2%	Explore
capillary endothelial cell	4 studies	18% ± 3%	Explore
lymphocyte	4 studies	22% ± 8%	Explore
retinal rod cell	4 studies	24% ± 8%	Explore
T follicular helper cell	4 studies	20% ± 2%	Explore
endothelial cell of vascular tree	4 studies	19% ± 1%	Explore
glutamatergic neuron	4 studies	34% ± 16%	Explore
interneuron	4 studies	28% ± 19%	Explore
respiratory goblet cell	3 studies	22% ± 7%	Explore
leukocyte	3 studies	19% ± 3%	Explore
retinal bipolar neuron	3 studies	27% ± 8%	Explore
microglial cell	3 studies	17% ± 2%	Explore
precursor B cell	3 studies	20% ± 4%	Explore
type I pneumocyte	3 studies	23% ± 3%	Explore
Mueller cell	3 studies	19% ± 3%	Explore
exhausted T cell	3 studies	16% ± 1%	Explore
dendritic cell	3 studies	32% ± 9%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	22% ± 4%	Explore
enteroendocrine cell	3 studies	24% ± 7%	Explore
intestinal crypt stem cell	3 studies	17% ± 0%	Explore
group 3 innate lymphoid cell	3 studies	37% ± 7%	Explore
vein endothelial cell	3 studies	17% ± 1%	Explore
transit amplifying cell	3 studies	24% ± 8%	Explore
oligodendrocyte	3 studies	26% ± 3%	Explore
double negative thymocyte	3 studies	30% ± 11%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	12 studies	21% ± 5%	Explore
lung	8 studies	23% ± 9%	Explore
eye	6 studies	22% ± 7%	Explore
brain	6 studies	26% ± 9%	Explore
lymph node	3 studies	17% ± 1%	Explore
intestine	3 studies	22% ± 7%	Explore
liver	3 studies	28% ± 7%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	5330.38	1445 / 1445	100%	121.36	183 / 183
ovary	100%	6789.63	180 / 180	100%	155.86	430 / 430
skin	100%	7501.51	1809 / 1809	100%	246.67	472 / 472
thymus	100%	5855.19	653 / 653	100%	207.56	605 / 605
prostate	100%	5452.32	245 / 245	100%	184.20	501 / 502
uterus	100%	6227.73	170 / 170	100%	190.59	458 / 459
pancreas	100%	3619.95	327 / 328	100%	156.69	178 / 178
brain	100%	5555.30	2637 / 2642	100%	217.51	704 / 705
kidney	100%	4269.58	89 / 89	100%	139.87	898 / 901
stomach	100%	4375.69	359 / 359	100%	186.41	285 / 286
lung	100%	4673.31	576 / 578	100%	149.60	1153 / 1155
breast	100%	6296.10	459 / 459	99%	211.03	1112 / 1118
intestine	100%	5636.59	966 / 966	99%	201.46	524 / 527
adrenal gland	100%	4583.90	258 / 258	99%	161.18	228 / 230
liver	100%	2342.23	225 / 226	100%	126.57	404 / 406
bladder	100%	6017.33	21 / 21	99%	174.74	499 / 504
adipose	100%	5861.54	1204 / 1204	0%	0	0 / 0
blood vessel	100%	6276.02	1335 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	100%	289.86	80 / 80
lymph node	0%	0	0 / 0	100%	219.59	29 / 29
muscle	100%	5403.61	803 / 803	0%	0	0 / 0
spleen	100%	6011.10	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	167.35	45 / 45
ureter	0%	0	0 / 0	100%	90.69	1 / 1
heart	98%	3372.98	843 / 861	0%	0	0 / 0
peripheral blood	97%	4507.68	900 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0000244	Biological process	spliceosomal tri-snRNP complex assembly
GO_0000398	Biological process	mRNA splicing, via spliceosome
GO_0008380	Biological process	RNA splicing
GO_0000245	Biological process	spliceosomal complex assembly
GO_0000375	Biological process	RNA splicing, via transesterification reactions
GO_0006403	Biological process	RNA localization
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0046540	Cellular component	U4/U6 x U5 tri-snRNP complex
GO_0005681	Cellular component	spliceosomal complex
GO_0016020	Cellular component	membrane
GO_0016607	Cellular component	nuclear speck
GO_0005654	Cellular component	nucleoplasm
GO_0071005	Cellular component	U2-type precatalytic spliceosome
GO_0005682	Cellular component	U5 snRNP
GO_0071013	Cellular component	catalytic step 2 spliceosome
GO_0005634	Cellular component	nucleus
GO_0043021	Molecular function	ribonucleoprotein complex binding
GO_0042802	Molecular function	identical protein binding
GO_0030674	Molecular function	protein-macromolecule adaptor activity
GO_0003723	Molecular function	RNA binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	PRPF6
Protein name	Pre-mRNA-processing factor 6 (Androgen receptor N-terminal domain-transactivating protein 1) (ANT-1) (PRP6 homolog) (U5 snRNP-associated 102 kDa protein) (U5-102 kDa protein)
Synonyms	C20orf14
Description	FUNCTION: Involved in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex, one of the building blocks of the spliceosome . Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation. .
Accessions	ENST00000266079.5 [O94906-1] O94906

PRPF6 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review