PPP4C | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	29 studies	29% ± 10%	Explore
B cell	24 studies	28% ± 10%	Explore
classical monocyte	24 studies	34% ± 14%	Explore
macrophage	24 studies	29% ± 12%	Explore
CD8-positive, alpha-beta T cell	23 studies	33% ± 15%	Explore
endothelial cell	22 studies	30% ± 14%	Explore
conventional dendritic cell	21 studies	34% ± 17%	Explore
CD4-positive, alpha-beta T cell	21 studies	30% ± 15%	Explore
non-classical monocyte	20 studies	40% ± 16%	Explore
T cell	20 studies	30% ± 10%	Explore
regulatory T cell	20 studies	32% ± 11%	Explore
monocyte	17 studies	33% ± 11%	Explore
memory B cell	17 studies	22% ± 5%	Explore
fibroblast	17 studies	24% ± 10%	Explore
epithelial cell	16 studies	36% ± 19%	Explore
plasmacytoid dendritic cell	15 studies	29% ± 11%	Explore
gamma-delta T cell	14 studies	29% ± 14%	Explore
endothelial cell of lymphatic vessel	13 studies	29% ± 11%	Explore
naive B cell	13 studies	22% ± 7%	Explore
mature NK T cell	13 studies	26% ± 7%	Explore
CD16-positive, CD56-dim natural killer cell, human	12 studies	31% ± 9%	Explore
basal cell	12 studies	36% ± 19%	Explore
dendritic cell	12 studies	38% ± 20%	Explore
capillary endothelial cell	12 studies	25% ± 10%	Explore
smooth muscle cell	12 studies	24% ± 6%	Explore
ciliated cell	11 studies	40% ± 17%	Explore
pericyte	11 studies	26% ± 8%	Explore
vein endothelial cell	11 studies	24% ± 9%	Explore
myeloid cell	11 studies	29% ± 13%	Explore
CD8-positive, alpha-beta memory T cell	10 studies	32% ± 14%	Explore
CD16-negative, CD56-bright natural killer cell, human	10 studies	29% ± 7%	Explore
connective tissue cell	10 studies	28% ± 10%	Explore
endothelial cell of artery	10 studies	25% ± 7%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	9 studies	21% ± 4%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	9 studies	28% ± 8%	Explore
abnormal cell	9 studies	30% ± 11%	Explore
endothelial cell of vascular tree	9 studies	24% ± 6%	Explore
CD4-positive, alpha-beta memory T cell	8 studies	32% ± 14%	Explore
secretory cell	8 studies	34% ± 17%	Explore
progenitor cell	8 studies	27% ± 12%	Explore
goblet cell	8 studies	26% ± 12%	Explore
mucosal invariant T cell	8 studies	24% ± 3%	Explore
plasmablast	7 studies	44% ± 24%	Explore
club cell	7 studies	29% ± 9%	Explore
myofibroblast cell	7 studies	26% ± 4%	Explore
type I pneumocyte	7 studies	27% ± 12%	Explore
T follicular helper cell	7 studies	23% ± 6%	Explore
plasma cell	6 studies	31% ± 11%	Explore
effector memory CD8-positive, alpha-beta T cell	6 studies	27% ± 8%	Explore
precursor B cell	6 studies	34% ± 13%	Explore
innate lymphoid cell	6 studies	26% ± 10%	Explore
mast cell	6 studies	20% ± 4%	Explore
hematopoietic precursor cell	5 studies	35% ± 16%	Explore
exhausted T cell	5 studies	42% ± 11%	Explore
respiratory goblet cell	5 studies	31% ± 20%	Explore
effector CD8-positive, alpha-beta T cell	5 studies	37% ± 16%	Explore
mononuclear phagocyte	5 studies	31% ± 18%	Explore
epithelial cell of proximal tubule	5 studies	20% ± 7%	Explore
enterocyte	5 studies	22% ± 2%	Explore
enteroendocrine cell	5 studies	34% ± 17%	Explore
transit amplifying cell	5 studies	22% ± 3%	Explore
pro-B cell	5 studies	35% ± 12%	Explore
neutrophil	4 studies	21% ± 3%	Explore
leukocyte	4 studies	30% ± 10%	Explore
kidney loop of Henle epithelial cell	4 studies	20% ± 2%	Explore
neuron	4 studies	42% ± 17%	Explore
alveolar macrophage	4 studies	20% ± 3%	Explore
intermediate monocyte	4 studies	44% ± 20%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	28% ± 4%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	40% ± 13%	Explore
erythrocyte	4 studies	32% ± 18%	Explore
T-helper 17 cell	4 studies	31% ± 20%	Explore
deuterosomal cell	3 studies	25% ± 9%	Explore
squamous epithelial cell	3 studies	45% ± 25%	Explore
glomerular endothelial cell	3 studies	19% ± 1%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	34% ± 10%	Explore
neural crest cell	3 studies	28% ± 8%	Explore
extravillous trophoblast	3 studies	35% ± 21%	Explore
placental villous trophoblast	3 studies	48% ± 20%	Explore
lymphocyte	3 studies	34% ± 11%	Explore
megakaryocyte	3 studies	25% ± 3%	Explore
immature B cell	3 studies	33% ± 7%	Explore
mesothelial cell	3 studies	40% ± 20%	Explore
type II pneumocyte	3 studies	33% ± 9%	Explore
intraepithelial lymphocyte	3 studies	34% ± 12%	Explore
germinal center B cell	3 studies	35% ± 6%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	46% ± 10%	Explore
group 3 innate lymphoid cell	3 studies	34% ± 14%	Explore
brush cell	3 studies	23% ± 8%	Explore
T-helper 1 cell	3 studies	37% ± 16%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	14 studies	32% ± 16%	Explore
peripheral blood	14 studies	31% ± 9%	Explore
intestine	8 studies	25% ± 12%	Explore
kidney	7 studies	23% ± 6%	Explore
lymph node	5 studies	26% ± 4%	Explore
bone marrow	4 studies	21% ± 6%	Explore
liver	4 studies	32% ± 25%	Explore
placenta	3 studies	39% ± 21%	Explore
brain	3 studies	24% ± 6%	Explore
breast	3 studies	22% ± 4%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
liver	100%	3047.57	226 / 226	100%	95.67	406 / 406
ovary	100%	2184.37	180 / 180	100%	179.18	430 / 430
skin	100%	4416.92	1809 / 1809	100%	125.87	472 / 472
uterus	100%	2730.82	170 / 170	100%	178.66	459 / 459
esophagus	100%	3673.70	1444 / 1445	100%	121.76	183 / 183
thymus	100%	2893.91	652 / 653	100%	123.27	604 / 605
intestine	100%	3306.58	966 / 966	100%	157.39	525 / 527
breast	100%	3206.14	459 / 459	99%	167.59	1112 / 1118
kidney	100%	3118.53	89 / 89	99%	92.13	896 / 901
lung	100%	3624.95	577 / 578	99%	140.33	1149 / 1155
stomach	100%	2729.90	359 / 359	99%	140.48	284 / 286
prostate	100%	3048.72	245 / 245	99%	101.72	498 / 502
adrenal gland	100%	3910.54	258 / 258	99%	78.18	228 / 230
bladder	100%	3012.62	21 / 21	99%	191.18	499 / 504
brain	99%	1651.65	2607 / 2642	100%	99.46	705 / 705
pancreas	99%	1654.23	325 / 328	99%	134.17	177 / 178
adipose	100%	3077.84	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	74.75	80 / 80
lymph node	0%	0	0 / 0	100%	226.71	29 / 29
spleen	100%	4694.83	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	146.20	45 / 45
ureter	0%	0	0 / 0	100%	190.46	1 / 1
peripheral blood	100%	7663.97	928 / 929	0%	0	0 / 0
muscle	100%	2435.40	801 / 803	0%	0	0 / 0
blood vessel	100%	2434.98	1331 / 1335	0%	0	0 / 0
heart	99%	1760.17	851 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0000724	Biological process	double-strand break repair via homologous recombination
GO_0010569	Biological process	regulation of double-strand break repair via homologous recombination
GO_2000779	Biological process	regulation of double-strand break repair
GO_0030289	Cellular component	protein phosphatase 4 complex
GO_0005813	Cellular component	centrosome
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0000785	Cellular component	chromatin
GO_0005886	Cellular component	plasma membrane
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0005515	Molecular function	protein binding
GO_0017018	Molecular function	myosin phosphatase activity
GO_0004722	Molecular function	protein serine/threonine phosphatase activity
GO_0046872	Molecular function	metal ion binding

IV. Literature review

[source]

Gene name	PPP4C
Protein name	Serine/threonine-protein phosphatase 4 catalytic subunit (EC 3.1.3.16) Serine/threonine-protein phosphatase 4 catalytic subunit (PP4C) (Pp4) (EC 3.1.3.16) (Protein phosphatase X) (PP-X) Protein phosphatase 4 catalytic subunit Serine/threonine-protein phosphatase (EC 3.1.3.16)
Synonyms	PPX hCG_1770706 PPP4
Description	FUNCTION: Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on Ser-140 (gamma-H2AX) generated during DNA replication and required for DNA double strand break repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase (By similarity). In response to DNA damage, catalyzes RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin. .
Accessions	ENST00000563597.5 ENST00000562222.5 ENST00000627746.2 ENST00000561610.1 A0A024R625 ENST00000566749.5 I3L4X0 H3BPN5 H3BTA2 ENST00000279387.12 P60510 ENST00000563732.5 ENST00000562664.5 H3BV22 H3BVE3

PPP4C report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review