POLR2K | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	32 studies	28% ± 8%	Explore
CD8-positive, alpha-beta T cell	27 studies	27% ± 10%	Explore
endothelial cell	25 studies	30% ± 13%	Explore
fibroblast	24 studies	29% ± 12%	Explore
B cell	23 studies	24% ± 8%	Explore
T cell	23 studies	25% ± 7%	Explore
CD4-positive, alpha-beta T cell	23 studies	26% ± 9%	Explore
smooth muscle cell	21 studies	26% ± 8%	Explore
pericyte	20 studies	28% ± 8%	Explore
regulatory T cell	18 studies	25% ± 4%	Explore
gamma-delta T cell	16 studies	27% ± 12%	Explore
epithelial cell	15 studies	36% ± 21%	Explore
endothelial cell of lymphatic vessel	13 studies	27% ± 10%	Explore
basal cell	13 studies	31% ± 16%	Explore
mature NK T cell	13 studies	25% ± 5%	Explore
memory B cell	13 studies	21% ± 6%	Explore
plasma cell	11 studies	32% ± 12%	Explore
macrophage	11 studies	25% ± 11%	Explore
CD16-negative, CD56-bright natural killer cell, human	11 studies	27% ± 5%	Explore
CD16-positive, CD56-dim natural killer cell, human	11 studies	25% ± 6%	Explore
conventional dendritic cell	11 studies	25% ± 14%	Explore
capillary endothelial cell	11 studies	23% ± 4%	Explore
connective tissue cell	11 studies	28% ± 9%	Explore
mast cell	10 studies	26% ± 7%	Explore
naive B cell	10 studies	20% ± 5%	Explore
mucosal invariant T cell	10 studies	22% ± 4%	Explore
endothelial cell of vascular tree	10 studies	26% ± 5%	Explore
plasmacytoid dendritic cell	10 studies	28% ± 11%	Explore
CD8-positive, alpha-beta memory T cell	9 studies	25% ± 6%	Explore
secretory cell	9 studies	31% ± 17%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	9 studies	22% ± 4%	Explore
myofibroblast cell	9 studies	27% ± 6%	Explore
vein endothelial cell	9 studies	20% ± 4%	Explore
CD4-positive, alpha-beta memory T cell	8 studies	22% ± 7%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	8 studies	18% ± 1%	Explore
non-classical monocyte	8 studies	27% ± 12%	Explore
endothelial cell of artery	8 studies	24% ± 6%	Explore
ciliated cell	8 studies	42% ± 18%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	26% ± 4%	Explore
effector memory CD8-positive, alpha-beta T cell	7 studies	26% ± 8%	Explore
epithelial cell of proximal tubule	7 studies	26% ± 8%	Explore
abnormal cell	7 studies	32% ± 15%	Explore
T follicular helper cell	7 studies	25% ± 4%	Explore
plasmablast	6 studies	37% ± 19%	Explore
club cell	6 studies	29% ± 11%	Explore
kidney loop of Henle epithelial cell	6 studies	29% ± 5%	Explore
neuron	6 studies	37% ± 19%	Explore
leukocyte	5 studies	25% ± 8%	Explore
monocyte	5 studies	21% ± 6%	Explore
precursor B cell	5 studies	29% ± 11%	Explore
effector CD4-positive, alpha-beta T cell	5 studies	23% ± 2%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	24% ± 7%	Explore
innate lymphoid cell	5 studies	30% ± 9%	Explore
pancreatic A cell	4 studies	56% ± 14%	Explore
type B pancreatic cell	4 studies	49% ± 20%	Explore
classical monocyte	4 studies	28% ± 9%	Explore
exhausted T cell	4 studies	29% ± 2%	Explore
renal alpha-intercalated cell	4 studies	38% ± 7%	Explore
myeloid cell	4 studies	27% ± 12%	Explore
type I pneumocyte	4 studies	32% ± 13%	Explore
type II pneumocyte	4 studies	36% ± 20%	Explore
erythrocyte	4 studies	28% ± 20%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	35% ± 5%	Explore
goblet cell	4 studies	29% ± 12%	Explore
T-helper 17 cell	4 studies	33% ± 11%	Explore
squamous epithelial cell	3 studies	39% ± 22%	Explore
pancreatic D cell	3 studies	53% ± 23%	Explore
glomerular endothelial cell	3 studies	25% ± 2%	Explore
podocyte	3 studies	33% ± 4%	Explore
progenitor cell	3 studies	22% ± 6%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	34% ± 4%	Explore
neural crest cell	3 studies	26% ± 5%	Explore
retinal ganglion cell	3 studies	69% ± 21%	Explore
erythroblast	3 studies	43% ± 25%	Explore
lymphocyte	3 studies	31% ± 12%	Explore
neuroendocrine cell	3 studies	40% ± 12%	Explore
immature B cell	3 studies	23% ± 5%	Explore
pro-B cell	3 studies	24% ± 2%	Explore
amacrine cell	3 studies	40% ± 14%	Explore
retina horizontal cell	3 studies	35% ± 15%	Explore
retinal cone cell	3 studies	64% ± 19%	Explore
retinal rod cell	3 studies	38% ± 14%	Explore
alveolar macrophage	3 studies	29% ± 4%	Explore
Mueller cell	3 studies	29% ± 9%	Explore
germinal center B cell	3 studies	25% ± 1%	Explore
CD4-positive helper T cell	3 studies	26% ± 9%	Explore
mesothelial cell	3 studies	32% ± 21%	Explore
dendritic cell	3 studies	44% ± 17%	Explore
pancreatic ductal cell	3 studies	49% ± 10%	Explore
enteroendocrine cell	3 studies	40% ± 21%	Explore
group 3 innate lymphoid cell	3 studies	37% ± 13%	Explore
mononuclear phagocyte	3 studies	28% ± 14%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	22% ± 2%	Explore
double negative thymocyte	3 studies	36% ± 16%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	14 studies	31% ± 14%	Explore
peripheral blood	12 studies	23% ± 6%	Explore
kidney	8 studies	25% ± 3%	Explore
intestine	8 studies	25% ± 12%	Explore
eye	5 studies	33% ± 16%	Explore
lymph node	5 studies	25% ± 7%	Explore
pancreas	4 studies	50% ± 19%	Explore
uterus	4 studies	31% ± 15%	Explore
liver	4 studies	34% ± 25%	Explore
breast	4 studies	25% ± 5%	Explore
brain	4 studies	21% ± 5%	Explore
bone marrow	3 studies	18% ± 0%	Explore
prostate	3 studies	25% ± 9%	Explore
thymus	3 studies	37% ± 13%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
adrenal gland	100%	2329.62	258 / 258	100%	114.20	230 / 230
brain	100%	2255.81	2642 / 2642	100%	88.75	705 / 705
esophagus	100%	1665.47	1445 / 1445	100%	104.23	183 / 183
liver	100%	998.58	226 / 226	100%	86.37	406 / 406
ovary	100%	1481.26	180 / 180	100%	165.50	430 / 430
uterus	100%	1751.19	170 / 170	100%	109.14	459 / 459
breast	100%	1882.83	459 / 459	100%	140.06	1117 / 1118
thymus	100%	1730.34	653 / 653	100%	83.36	604 / 605
prostate	100%	1744.83	245 / 245	100%	85.47	501 / 502
lung	100%	1656.73	576 / 578	100%	106.97	1155 / 1155
bladder	100%	1813.90	21 / 21	100%	113.78	502 / 504
kidney	100%	2009.37	89 / 89	99%	65.46	895 / 901
skin	100%	1595.62	1807 / 1809	99%	99.05	469 / 472
stomach	100%	1457.87	359 / 359	99%	111.16	283 / 286
intestine	100%	1733.83	966 / 966	98%	94.26	517 / 527
pancreas	99%	742.13	324 / 328	99%	74.33	176 / 178
blood vessel	100%	2354.24	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	90.84	29 / 29
spleen	100%	1464.52	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	92.10	45 / 45
ureter	0%	0	0 / 0	100%	105.37	1 / 1
adipose	100%	1849.50	1203 / 1204	0%	0	0 / 0
muscle	99%	852.90	793 / 803	0%	0	0 / 0
heart	98%	1245.54	847 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	94%	70.68	75 / 80
peripheral blood	40%	781.10	367 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006366	Biological process	transcription by RNA polymerase II
GO_0006360	Biological process	transcription by RNA polymerase I
GO_0006356	Biological process	regulation of transcription by RNA polymerase I
GO_0006383	Biological process	transcription by RNA polymerase III
GO_0005736	Cellular component	RNA polymerase I complex
GO_0005665	Cellular component	RNA polymerase II, core complex
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0005666	Cellular component	RNA polymerase III complex
GO_0005634	Cellular component	nucleus
GO_0003677	Molecular function	DNA binding
GO_0001055	Molecular function	RNA polymerase II activity
GO_0001056	Molecular function	RNA polymerase III activity
GO_0001054	Molecular function	RNA polymerase I activity
GO_0005515	Molecular function	protein binding
GO_0008270	Molecular function	zinc ion binding

IV. Literature review

[source]

Gene name	POLR2K
Protein name	RNA polymerase II, I and III subunit K DNA-directed RNA polymerases I, II, and III subunit RPABC4 (RNA polymerases I, II, and III subunit ABC4) (ABC10-alpha) (DNA-directed RNA polymerase II subunit K) (RNA polymerase II 7.0 kDa subunit) (RPB7.0) (RPB10alpha)
Synonyms
Description	FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively. .
Accessions	E5RGX2 ENST00000353107.8 P53803 ENST00000522439.1

POLR2K report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review