PGLS | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	29 studies	39% ± 12%	Explore
natural killer cell	29 studies	26% ± 9%	Explore
conventional dendritic cell	27 studies	55% ± 17%	Explore
B cell	26 studies	30% ± 10%	Explore
fibroblast	26 studies	28% ± 11%	Explore
classical monocyte	25 studies	52% ± 15%	Explore
CD4-positive, alpha-beta T cell	24 studies	25% ± 8%	Explore
non-classical monocyte	23 studies	59% ± 16%	Explore
regulatory T cell	22 studies	27% ± 8%	Explore
CD8-positive, alpha-beta T cell	21 studies	27% ± 9%	Explore
dendritic cell	19 studies	53% ± 22%	Explore
plasmacytoid dendritic cell	19 studies	41% ± 12%	Explore
T cell	18 studies	23% ± 6%	Explore
monocyte	18 studies	45% ± 11%	Explore
memory B cell	18 studies	28% ± 8%	Explore
endothelial cell	18 studies	32% ± 13%	Explore
epithelial cell	17 studies	38% ± 20%	Explore
naive B cell	16 studies	21% ± 5%	Explore
endothelial cell of lymphatic vessel	15 studies	31% ± 12%	Explore
pericyte	14 studies	26% ± 10%	Explore
basal cell	13 studies	36% ± 21%	Explore
ciliated cell	13 studies	36% ± 17%	Explore
mature NK T cell	13 studies	25% ± 8%	Explore
connective tissue cell	13 studies	34% ± 10%	Explore
gamma-delta T cell	13 studies	28% ± 15%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	12 studies	24% ± 8%	Explore
myeloid cell	12 studies	42% ± 18%	Explore
CD16-negative, CD56-bright natural killer cell, human	11 studies	30% ± 9%	Explore
CD16-positive, CD56-dim natural killer cell, human	10 studies	30% ± 7%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	10 studies	28% ± 10%	Explore
abnormal cell	10 studies	30% ± 11%	Explore
smooth muscle cell	10 studies	25% ± 7%	Explore
myofibroblast cell	9 studies	31% ± 6%	Explore
mucosal invariant T cell	9 studies	22% ± 5%	Explore
CD8-positive, alpha-beta memory T cell	8 studies	28% ± 13%	Explore
secretory cell	8 studies	34% ± 19%	Explore
progenitor cell	8 studies	41% ± 10%	Explore
goblet cell	8 studies	24% ± 12%	Explore
CD4-positive, alpha-beta memory T cell	7 studies	30% ± 6%	Explore
club cell	7 studies	29% ± 7%	Explore
innate lymphoid cell	7 studies	26% ± 5%	Explore
enterocyte	6 studies	26% ± 5%	Explore
leukocyte	6 studies	36% ± 17%	Explore
neuron	6 studies	41% ± 20%	Explore
T follicular helper cell	6 studies	26% ± 6%	Explore
alveolar macrophage	5 studies	30% ± 3%	Explore
hematopoietic precursor cell	5 studies	51% ± 23%	Explore
respiratory goblet cell	5 studies	29% ± 17%	Explore
mononuclear phagocyte	5 studies	45% ± 21%	Explore
effector memory CD8-positive, alpha-beta T cell	5 studies	33% ± 8%	Explore
epithelial cell of proximal tubule	5 studies	25% ± 6%	Explore
enteroendocrine cell	5 studies	39% ± 16%	Explore
mesothelial cell	5 studies	43% ± 16%	Explore
vein endothelial cell	5 studies	35% ± 16%	Explore
hematopoietic stem cell	5 studies	47% ± 13%	Explore
capillary endothelial cell	5 studies	30% ± 16%	Explore
type II pneumocyte	5 studies	31% ± 12%	Explore
mast cell	5 studies	27% ± 9%	Explore
effector CD8-positive, alpha-beta T cell	5 studies	31% ± 9%	Explore
intermediate monocyte	5 studies	61% ± 17%	Explore
type I pneumocyte	4 studies	31% ± 12%	Explore
exhausted T cell	4 studies	34% ± 12%	Explore
kidney loop of Henle epithelial cell	4 studies	19% ± 4%	Explore
precursor B cell	4 studies	34% ± 6%	Explore
pro-B cell	4 studies	32% ± 8%	Explore
plasma cell	4 studies	26% ± 8%	Explore
microglial cell	4 studies	26% ± 12%	Explore
endothelial cell of vascular tree	4 studies	21% ± 1%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	38% ± 5%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	25% ± 7%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	34% ± 8%	Explore
neutrophil	4 studies	25% ± 4%	Explore
T-helper 17 cell	4 studies	18% ± 2%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	23% ± 8%	Explore
deuterosomal cell	3 studies	29% ± 9%	Explore
duct epithelial cell	3 studies	28% ± 11%	Explore
precursor cell	3 studies	45% ± 12%	Explore
plasmablast	3 studies	43% ± 18%	Explore
pancreatic A cell	3 studies	32% ± 18%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	27% ± 8%	Explore
renal alpha-intercalated cell	3 studies	31% ± 2%	Explore
neural crest cell	3 studies	32% ± 2%	Explore
common myeloid progenitor	3 studies	49% ± 19%	Explore
lymphocyte	3 studies	39% ± 10%	Explore
megakaryocyte	3 studies	26% ± 12%	Explore
immature B cell	3 studies	34% ± 7%	Explore
serous secreting cell	3 studies	33% ± 1%	Explore
germinal center B cell	3 studies	41% ± 6%	Explore
glutamatergic neuron	3 studies	20% ± 2%	Explore
granulocyte monocyte progenitor cell	3 studies	47% ± 19%	Explore
group 3 innate lymphoid cell	3 studies	42% ± 17%	Explore
transit amplifying cell	3 studies	19% ± 3%	Explore
double negative thymocyte	3 studies	40% ± 16%	Explore
progenitor cell of mammary luminal epithelium	3 studies	27% ± 6%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	17 studies	35% ± 11%	Explore
lung	15 studies	32% ± 16%	Explore
intestine	9 studies	28% ± 12%	Explore
kidney	7 studies	26% ± 6%	Explore
lymph node	5 studies	29% ± 11%	Explore
liver	5 studies	26% ± 13%	Explore
uterus	4 studies	34% ± 17%	Explore
breast	4 studies	22% ± 5%	Explore
brain	4 studies	19% ± 3%	Explore
placenta	3 studies	23% ± 2%	Explore
bone marrow	3 studies	31% ± 9%	Explore
skin	3 studies	20% ± 5%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
adrenal gland	100%	2954.87	258 / 258	100%	48.54	230 / 230
ovary	100%	2120.24	180 / 180	100%	120.79	430 / 430
pancreas	100%	1797.12	328 / 328	100%	59.79	178 / 178
thymus	100%	2393.92	653 / 653	100%	71.77	605 / 605
uterus	100%	1671.50	170 / 170	100%	68.68	459 / 459
esophagus	100%	2138.59	1444 / 1445	100%	46.92	183 / 183
liver	100%	1486.21	226 / 226	100%	49.58	405 / 406
stomach	100%	1553.18	359 / 359	100%	57.59	285 / 286
kidney	100%	2139.12	89 / 89	100%	55.77	897 / 901
intestine	100%	1748.14	966 / 966	99%	69.74	524 / 527
brain	99%	1015.57	2624 / 2642	100%	56.39	705 / 705
skin	100%	2763.09	1804 / 1809	100%	61.60	470 / 472
prostate	100%	2327.45	245 / 245	99%	82.72	498 / 502
breast	100%	2324.19	459 / 459	99%	63.39	1108 / 1118
bladder	100%	1860.76	21 / 21	99%	76.23	499 / 504
lung	100%	1882.68	576 / 578	99%	50.66	1145 / 1155
adipose	100%	2390.41	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	121.38	80 / 80
lymph node	0%	0	0 / 0	100%	116.32	29 / 29
spleen	100%	2851.85	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	59.94	45 / 45
ureter	0%	0	0 / 0	100%	82.65	1 / 1
blood vessel	100%	1558.92	1330 / 1335	0%	0	0 / 0
peripheral blood	99%	3150.64	922 / 929	0%	0	0 / 0
heart	94%	748.28	813 / 861	0%	0	0 / 0
muscle	54%	291.33	434 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

IV. Literature review

[source]

Gene name	PGLS
Protein name	6-phosphogluconolactonase 6-phosphogluconolactonase (6PGL) (EC 3.1.1.31)
Synonyms	HEL-S-304 hCG_1778174
Description	FUNCTION: Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. . FUNCTION: Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. . FUNCTION: Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. . FUNCTION: Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. .
Accessions	ENST00000594761.5 M0R1L2 ENST00000595782.1 ENST00000252603.7 A0A0K0K1K7 ENST00000600923.5 M0R0U3 O95336 M0R261

GO_0005975	Biological process	carbohydrate metabolic process
GO_0006098	Biological process	pentose-phosphate shunt
GO_0009051	Biological process	pentose-phosphate shunt, oxidative branch
GO_0070062	Cellular component	extracellular exosome
GO_0005829	Cellular component	cytosol
GO_0017057	Molecular function	6-phosphogluconolactonase activity
GO_0005515	Molecular function	protein binding

PGLS report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review