NRDC | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	22 studies	22% ± 5%	Explore
fibroblast	22 studies	25% ± 9%	Explore
macrophage	22 studies	26% ± 13%	Explore
endothelial cell	21 studies	29% ± 11%	Explore
B cell	19 studies	21% ± 6%	Explore
regulatory T cell	19 studies	20% ± 4%	Explore
plasmacytoid dendritic cell	17 studies	33% ± 10%	Explore
classical monocyte	15 studies	23% ± 8%	Explore
plasma cell	14 studies	31% ± 14%	Explore
ciliated cell	14 studies	30% ± 10%	Explore
CD8-positive, alpha-beta T cell	14 studies	22% ± 4%	Explore
astrocyte	14 studies	35% ± 17%	Explore
T cell	13 studies	22% ± 5%	Explore
monocyte	13 studies	25% ± 11%	Explore
CD16-negative, CD56-bright natural killer cell, human	13 studies	21% ± 3%	Explore
CD16-positive, CD56-dim natural killer cell, human	13 studies	21% ± 3%	Explore
smooth muscle cell	12 studies	21% ± 5%	Explore
oligodendrocyte	12 studies	39% ± 16%	Explore
naive B cell	11 studies	19% ± 4%	Explore
CD4-positive, alpha-beta T cell	11 studies	20% ± 5%	Explore
pericyte	11 studies	23% ± 9%	Explore
basal cell	10 studies	29% ± 16%	Explore
epithelial cell	10 studies	35% ± 19%	Explore
non-classical monocyte	10 studies	24% ± 7%	Explore
GABAergic neuron	10 studies	41% ± 23%	Explore
oligodendrocyte precursor cell	10 studies	38% ± 18%	Explore
mucosal invariant T cell	10 studies	19% ± 2%	Explore
microglial cell	10 studies	35% ± 15%	Explore
gamma-delta T cell	10 studies	23% ± 11%	Explore
type I pneumocyte	9 studies	24% ± 7%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	9 studies	18% ± 3%	Explore
conventional dendritic cell	9 studies	26% ± 11%	Explore
glutamatergic neuron	9 studies	51% ± 25%	Explore
myeloid cell	9 studies	30% ± 8%	Explore
adipocyte	9 studies	45% ± 15%	Explore
effector memory CD8-positive, alpha-beta T cell	8 studies	21% ± 3%	Explore
mature NK T cell	8 studies	20% ± 4%	Explore
dendritic cell	8 studies	33% ± 15%	Explore
endothelial cell of lymphatic vessel	8 studies	25% ± 7%	Explore
plasmablast	7 studies	36% ± 19%	Explore
CD8-positive, alpha-beta memory T cell	7 studies	22% ± 4%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	7 studies	19% ± 2%	Explore
neuron	7 studies	40% ± 17%	Explore
myofibroblast cell	7 studies	22% ± 5%	Explore
type II pneumocyte	7 studies	24% ± 6%	Explore
amacrine cell	7 studies	27% ± 9%	Explore
memory B cell	7 studies	19% ± 3%	Explore
respiratory goblet cell	6 studies	27% ± 9%	Explore
renal alpha-intercalated cell	6 studies	44% ± 7%	Explore
hematopoietic stem cell	6 studies	23% ± 7%	Explore
platelet	6 studies	21% ± 7%	Explore
club cell	6 studies	24% ± 8%	Explore
retina horizontal cell	6 studies	27% ± 7%	Explore
retinal rod cell	6 studies	21% ± 4%	Explore
hematopoietic precursor cell	5 studies	27% ± 9%	Explore
CD4-positive, alpha-beta memory T cell	5 studies	20% ± 4%	Explore
effector CD8-positive, alpha-beta T cell	5 studies	20% ± 4%	Explore
leukocyte	5 studies	25% ± 9%	Explore
retinal bipolar neuron	5 studies	23% ± 6%	Explore
lymphocyte	5 studies	28% ± 8%	Explore
precursor B cell	5 studies	24% ± 7%	Explore
cardiac muscle cell	5 studies	33% ± 5%	Explore
mast cell	5 studies	25% ± 8%	Explore
Mueller cell	5 studies	26% ± 7%	Explore
T follicular helper cell	5 studies	18% ± 1%	Explore
endothelial cell of vascular tree	5 studies	22% ± 11%	Explore
connective tissue cell	5 studies	22% ± 4%	Explore
goblet cell	5 studies	25% ± 13%	Explore
interneuron	5 studies	53% ± 19%	Explore
secretory cell	4 studies	30% ± 14%	Explore
exhausted T cell	4 studies	24% ± 7%	Explore
retinal ganglion cell	4 studies	37% ± 13%	Explore
megakaryocyte	4 studies	39% ± 14%	Explore
immature B cell	4 studies	20% ± 3%	Explore
mesothelial cell	4 studies	25% ± 10%	Explore
muscle cell	4 studies	37% ± 17%	Explore
abnormal cell	4 studies	31% ± 13%	Explore
alveolar macrophage	4 studies	33% ± 12%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	20% ± 2%	Explore
ionocyte	3 studies	23% ± 3%	Explore
neutrophil	3 studies	23% ± 4%	Explore
retinal cone cell	3 studies	30% ± 2%	Explore
retinal pigment epithelial cell	3 studies	35% ± 19%	Explore
glial cell	3 studies	23% ± 7%	Explore
mononuclear phagocyte	3 studies	31% ± 1%	Explore
vein endothelial cell	3 studies	23% ± 9%	Explore
OFF-bipolar cell	3 studies	24% ± 7%	Explore
ON-bipolar cell	3 studies	25% ± 7%	Explore
glycinergic amacrine cell	3 studies	23% ± 4%	Explore
rod bipolar cell	3 studies	30% ± 7%	Explore
erythroblast	3 studies	26% ± 14%	Explore
intermediate monocyte	3 studies	30% ± 15%	Explore
innate lymphoid cell	3 studies	19% ± 1%	Explore
hepatocyte	3 studies	50% ± 19%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	20% ± 3%	Explore
capillary endothelial cell	3 studies	18% ± 2%	Explore
group 3 innate lymphoid cell	3 studies	26% ± 10%	Explore
transit amplifying cell	3 studies	38% ± 25%	Explore
brush cell	3 studies	20% ± 3%	Explore
granule cell	3 studies	28% ± 7%	Explore
double negative thymocyte	3 studies	31% ± 13%	Explore
IgG plasma cell	3 studies	20% ± 4%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	15 studies	40% ± 21%	Explore
lung	14 studies	24% ± 10%	Explore
peripheral blood	12 studies	21% ± 6%	Explore
eye	7 studies	29% ± 12%	Explore
heart	5 studies	26% ± 5%	Explore
liver	5 studies	32% ± 14%	Explore
bone marrow	4 studies	20% ± 7%	Explore
kidney	4 studies	19% ± 2%	Explore
adipose	4 studies	39% ± 22%	Explore
intestine	3 studies	22% ± 5%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
bladder	100%	7923.95	21 / 21	100%	61.79	504 / 504
breast	100%	7750.62	459 / 459	100%	76.67	1118 / 1118
esophagus	100%	7333.47	1445 / 1445	100%	64.32	183 / 183
liver	100%	7075.32	226 / 226	100%	47.27	406 / 406
ovary	100%	7824.68	180 / 180	100%	43.30	430 / 430
prostate	100%	8667.94	245 / 245	100%	73.27	502 / 502
stomach	100%	5961.34	359 / 359	100%	47.60	286 / 286
thymus	100%	7607.14	653 / 653	100%	50.68	605 / 605
uterus	100%	7855.74	170 / 170	100%	73.67	459 / 459
lung	100%	8724.43	577 / 578	100%	63.47	1155 / 1155
intestine	100%	7831.21	966 / 966	100%	49.64	526 / 527
skin	100%	12168.15	1808 / 1809	100%	67.06	471 / 472
kidney	100%	6514.11	89 / 89	99%	44.81	896 / 901
brain	99%	6170.94	2619 / 2642	100%	53.79	705 / 705
pancreas	99%	5051.99	325 / 328	100%	50.14	178 / 178
adrenal gland	100%	8503.38	258 / 258	98%	42.06	226 / 230
adipose	100%	8129.08	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	63.21	29 / 29
muscle	100%	28201.79	803 / 803	0%	0	0 / 0
spleen	100%	11136.00	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	74.09	45 / 45
ureter	0%	0	0 / 0	100%	34.90	1 / 1
blood vessel	100%	7249.87	1334 / 1335	0%	0	0 / 0
peripheral blood	100%	13848.50	925 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	96%	39.06	77 / 80
heart	96%	7276.11	826 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0031643	Biological process	positive regulation of myelination
GO_0050772	Biological process	positive regulation of axonogenesis
GO_0051044	Biological process	positive regulation of membrane protein ectodomain proteolysis
GO_0006508	Biological process	proteolysis
GO_0052548	Biological process	regulation of endopeptidase activity
GO_0120163	Biological process	negative regulation of cold-induced thermogenesis
GO_0009986	Cellular component	cell surface
GO_0005829	Cellular component	cytosol
GO_0005739	Cellular component	mitochondrion
GO_0030425	Cellular component	dendrite
GO_0004222	Molecular function	metalloendopeptidase activity
GO_0048408	Molecular function	epidermal growth factor binding
GO_0005515	Molecular function	protein binding
GO_0046872	Molecular function	metal ion binding

IV. Literature review

[source]

Gene name	NRDC
Protein name	Nardilysin convertase Nardilysin (N-arginine dibasic convertase), isoform CRA_e (Nardilysin convertase) Nardilysin Nardilysin isoform Nardilysin (EC 3.4.24.61) (N-arginine dibasic convertase) (NRD convertase) (NRD-C) (Nardilysin convertase)
Synonyms	NRD1 hCG_40292
Description	FUNCTION: Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs. Is a critical activator of BACE1- and ADAM17-mediated pro-neuregulin ectodomain shedding, involved in the positive regulation of axonal maturation and myelination. Required for proper functioning of 2-oxoglutarate dehydrogenase (OGDH) (By similarity). .
Accessions	ENST00000354831.11 [O43847-2] G3V1R5 Q96L67 ENST00000440943.5 ENST00000352171.12 [O43847-1] O43847 Q6UUU9 ENST00000539524.5 H0Y5G9

NRDC report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review