KAT6B | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	20 studies	22% ± 6%	Explore
fibroblast	20 studies	28% ± 12%	Explore
endothelial cell	18 studies	32% ± 15%	Explore
T cell	13 studies	26% ± 7%	Explore
pericyte	13 studies	30% ± 12%	Explore
astrocyte	13 studies	39% ± 18%	Explore
smooth muscle cell	12 studies	26% ± 6%	Explore
CD8-positive, alpha-beta T cell	12 studies	18% ± 3%	Explore
CD16-negative, CD56-bright natural killer cell, human	11 studies	26% ± 6%	Explore
regulatory T cell	11 studies	20% ± 4%	Explore
B cell	10 studies	21% ± 5%	Explore
glutamatergic neuron	10 studies	48% ± 21%	Explore
CD16-positive, CD56-dim natural killer cell, human	10 studies	25% ± 7%	Explore
CD4-positive, alpha-beta T cell	10 studies	22% ± 7%	Explore
mast cell	10 studies	24% ± 8%	Explore
adipocyte	9 studies	41% ± 11%	Explore
gamma-delta T cell	9 studies	24% ± 10%	Explore
naive B cell	8 studies	20% ± 3%	Explore
GABAergic neuron	8 studies	45% ± 19%	Explore
epithelial cell	8 studies	35% ± 18%	Explore
microglial cell	8 studies	26% ± 12%	Explore
oligodendrocyte precursor cell	8 studies	37% ± 15%	Explore
oligodendrocyte	8 studies	33% ± 12%	Explore
type I pneumocyte	7 studies	30% ± 11%	Explore
neuron	7 studies	44% ± 18%	Explore
mucosal invariant T cell	7 studies	22% ± 3%	Explore
CD8-positive, alpha-beta memory T cell	7 studies	22% ± 3%	Explore
endothelial cell of lymphatic vessel	7 studies	26% ± 8%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	6 studies	21% ± 4%	Explore
amacrine cell	6 studies	32% ± 10%	Explore
retina horizontal cell	6 studies	26% ± 9%	Explore
Mueller cell	6 studies	30% ± 12%	Explore
basal cell	6 studies	28% ± 15%	Explore
CD4-positive, alpha-beta memory T cell	5 studies	20% ± 3%	Explore
effector memory CD8-positive, alpha-beta T cell	5 studies	28% ± 7%	Explore
mature NK T cell	5 studies	23% ± 6%	Explore
progenitor cell	5 studies	34% ± 17%	Explore
interneuron	5 studies	65% ± 17%	Explore
macrophage	5 studies	34% ± 10%	Explore
cardiac muscle cell	5 studies	53% ± 13%	Explore
ciliated cell	5 studies	25% ± 9%	Explore
myeloid cell	5 studies	20% ± 4%	Explore
T follicular helper cell	5 studies	21% ± 7%	Explore
myofibroblast cell	5 studies	28% ± 10%	Explore
type II pneumocyte	5 studies	28% ± 8%	Explore
abnormal cell	4 studies	26% ± 12%	Explore
granule cell	4 studies	42% ± 10%	Explore
pro-B cell	4 studies	24% ± 2%	Explore
mesothelial cell	4 studies	34% ± 12%	Explore
lymphocyte	4 studies	37% ± 10%	Explore
retinal cone cell	4 studies	25% ± 10%	Explore
retinal rod cell	4 studies	38% ± 9%	Explore
innate lymphoid cell	4 studies	18% ± 2%	Explore
dendritic cell	4 studies	26% ± 6%	Explore
connective tissue cell	4 studies	21% ± 5%	Explore
hematopoietic stem cell	4 studies	22% ± 5%	Explore
club cell	4 studies	28% ± 10%	Explore
classical monocyte	3 studies	19% ± 2%	Explore
leukocyte	3 studies	27% ± 8%	Explore
non-classical monocyte	3 studies	19% ± 3%	Explore
conventional dendritic cell	3 studies	24% ± 8%	Explore
hematopoietic precursor cell	3 studies	27% ± 8%	Explore
plasmablast	3 studies	33% ± 10%	Explore
glial cell	3 studies	30% ± 14%	Explore
memory B cell	3 studies	16% ± 1%	Explore
plasmacytoid dendritic cell	3 studies	18% ± 2%	Explore
precursor B cell	3 studies	22% ± 5%	Explore
plasma cell	3 studies	32% ± 5%	Explore
retinal bipolar neuron	3 studies	29% ± 10%	Explore
GABAergic amacrine cell	3 studies	44% ± 12%	Explore
OFF-bipolar cell	3 studies	32% ± 13%	Explore
ON-bipolar cell	3 studies	36% ± 13%	Explore
glycinergic amacrine cell	3 studies	33% ± 9%	Explore
retinal ganglion cell	3 studies	34% ± 14%	Explore
rod bipolar cell	3 studies	21% ± 6%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	21% ± 4%	Explore
endothelial cell of vascular tree	3 studies	26% ± 7%	Explore
hepatocyte	3 studies	44% ± 14%	Explore
alveolar macrophage	3 studies	24% ± 7%	Explore
monocyte	3 studies	27% ± 1%	Explore
respiratory goblet cell	3 studies	34% ± 11%	Explore
goblet cell	3 studies	48% ± 30%	Explore
mucus secreting cell	3 studies	31% ± 12%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	13 studies	40% ± 18%	Explore
lung	6 studies	22% ± 7%	Explore
eye	6 studies	34% ± 12%	Explore
peripheral blood	5 studies	22% ± 8%	Explore
heart	5 studies	32% ± 11%	Explore
intestine	4 studies	18% ± 2%	Explore
adipose	3 studies	38% ± 10%	Explore
kidney	3 studies	22% ± 5%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	3274.39	1444 / 1445	100%	5.35	183 / 183
ovary	100%	4578.53	180 / 180	99%	5.60	426 / 430
breast	100%	3082.52	459 / 459	99%	10.50	1106 / 1118
thymus	100%	3156.27	653 / 653	99%	6.12	598 / 605
brain	100%	2277.86	2638 / 2642	98%	6.29	691 / 705
lung	100%	2686.99	576 / 578	98%	3.91	1132 / 1155
prostate	100%	2712.21	245 / 245	98%	4.38	490 / 502
stomach	100%	2954.41	359 / 359	97%	3.74	277 / 286
adrenal gland	100%	2382.22	257 / 258	97%	3.98	222 / 230
pancreas	100%	1833.88	328 / 328	96%	3.10	171 / 178
intestine	100%	3303.07	966 / 966	96%	3.00	506 / 527
kidney	100%	1534.81	89 / 89	93%	3.26	841 / 901
bladder	100%	3536.48	21 / 21	91%	2.59	459 / 504
uterus	100%	4000.44	170 / 170	90%	3.23	414 / 459
skin	100%	2967.65	1808 / 1809	89%	2.45	420 / 472
liver	98%	935.81	221 / 226	50%	0.95	204 / 406
adipose	100%	2845.85	1204 / 1204	0%	0	0 / 0
blood vessel	100%	3144.03	1335 / 1335	0%	0	0 / 0
muscle	100%	2542.50	803 / 803	0%	0	0 / 0
spleen	100%	2111.00	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	1.10	1 / 1
heart	97%	1819.95	832 / 861	0%	0	0 / 0
tonsil	0%	0	0 / 0	84%	3.00	38 / 45
lymph node	0%	0	0 / 0	83%	2.47	24 / 29
eye	0%	0	0 / 0	78%	1.73	62 / 80
peripheral blood	47%	1229.28	436 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_1903706	Biological process	regulation of hemopoiesis
GO_0006357	Biological process	regulation of transcription by RNA polymerase II
GO_0006334	Biological process	nucleosome assembly
GO_0045893	Biological process	positive regulation of DNA-templated transcription
GO_0006355	Biological process	regulation of DNA-templated transcription
GO_0045892	Biological process	negative regulation of DNA-templated transcription
GO_0050793	Biological process	regulation of developmental process
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0000786	Cellular component	nucleosome
GO_0005654	Cellular component	nucleoplasm
GO_0070776	Cellular component	MOZ/MORF histone acetyltransferase complex
GO_0000785	Cellular component	chromatin
GO_0005634	Cellular component	nucleus
GO_0003677	Molecular function	DNA binding
GO_0036408	Molecular function	histone H3K14 acetyltransferase activity
GO_0061733	Molecular function	peptide-lysine-N-acetyltransferase activity
GO_0003682	Molecular function	chromatin binding
GO_0010484	Molecular function	histone H3 acetyltransferase activity
GO_0003712	Molecular function	transcription coregulator activity
GO_0046872	Molecular function	metal ion binding
GO_0004402	Molecular function	histone acetyltransferase activity
GO_0003713	Molecular function	transcription coactivator activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	KAT6B
Protein name	Lysine acetyltransferase 6B histone acetyltransferase (EC 2.3.1.48) Histone acetyltransferase KAT6B (EC 2.3.1.48) (Histone acetyltransferase MOZ2) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4) (MYST-4) (Monocytic leukemia zinc finger protein-related factor)
Synonyms	MORF KIAA0383 MYST4 MOZ2
Description	FUNCTION: Histone acetyltransferase which may be involved in both positive and negative regulation of transcription. Required for RUNX2-dependent transcriptional activation. May be involved in cerebral cortex development. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. .
Accessions	ENST00000650575.1 [Q8WYB5-3] ENST00000648725.1 [Q8WYB5-1] ENST00000604130.1 ENST00000372724.6 [Q8WYB5-2] ENST00000628038.3 [Q8WYB5-3] ENST00000647630.1 [Q8WYB5-1] ENST00000647637.1 ENST00000649375.1 A0A3B3ITC3 ENST00000649657.1 ENST00000648696.1 A0A3B3IRI4 ENST00000629233.3 [Q8WYB5-3] ENST00000650232.1 ENST00000648369.1 A0A3B3IS73 A0A3B3IUA4 A0A3B3ISD0 ENST00000372725.6 [Q8WYB5-3] A0A3B3ISI1 A0A3B3IT19 ENST00000647890.1 ENST00000372711.2 [Q8WYB5-2] A0A3B3IT63 ENST00000649574.1 [Q8WYB5-3] ENST00000648159.1 ENST00000648605.1 [Q8WYB5-1] ENST00000648539.1 A0A3B3ISF5 A0A3B3IRN9 ENST00000647642.1 ENST00000629879.2 [Q8WYB5-2] ENST00000648892.1 [Q8WYB5-3] ENST00000649463.1 [Q8WYB5-1] ENST00000287239.10 [Q8WYB5-1] ENST00000648899.1 A0A3B3ITA4 ENST00000648828.1 ENST00000647666.1 ENST00000630001.4 [Q8WYB5-1] ENST00000628523.3 [Q8WYB5-2] A0A3B3ITI0 Q8WYB5 A0A3B3IRV4 A0A3B3ITV5 ENST00000649442.1 ENST00000648483.1 A0A3B3ISW3 ENST00000648048.1 ENST00000372714.6 [Q8WYB5-3] A0A3B3ISD5 ENST00000650048.1 ENST00000649006.1 [Q8WYB5-3] ENST00000648370.1 A0A3B3IU71 ENST00000647554.1 ENST00000650434.1 A0A3B3IU93 A0A3B3ITP3 ENST00000649119.1 A0A3B3ISX5 A0A3B3IU70

KAT6B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review