IKZF1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	38 studies	36% ± 13%	Explore
CD4-positive, alpha-beta T cell	35 studies	41% ± 17%	Explore
B cell	34 studies	35% ± 13%	Explore
CD8-positive, alpha-beta T cell	34 studies	39% ± 14%	Explore
T cell	33 studies	38% ± 16%	Explore
regulatory T cell	25 studies	37% ± 11%	Explore
non-classical monocyte	21 studies	35% ± 15%	Explore
mast cell	19 studies	36% ± 15%	Explore
mature NK T cell	19 studies	35% ± 13%	Explore
plasmacytoid dendritic cell	19 studies	39% ± 12%	Explore
naive B cell	19 studies	31% ± 8%	Explore
memory B cell	18 studies	31% ± 7%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	18 studies	47% ± 18%	Explore
gamma-delta T cell	18 studies	37% ± 12%	Explore
classical monocyte	17 studies	25% ± 14%	Explore
CD16-negative, CD56-bright natural killer cell, human	16 studies	36% ± 15%	Explore
monocyte	15 studies	29% ± 12%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	15 studies	39% ± 15%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	43% ± 14%	Explore
macrophage	15 studies	29% ± 15%	Explore
dendritic cell	14 studies	36% ± 19%	Explore
mucosal invariant T cell	14 studies	38% ± 13%	Explore
CD8-positive, alpha-beta memory T cell	13 studies	42% ± 8%	Explore
microglial cell	13 studies	47% ± 19%	Explore
CD4-positive, alpha-beta memory T cell	12 studies	41% ± 11%	Explore
effector memory CD8-positive, alpha-beta T cell	12 studies	46% ± 16%	Explore
myeloid cell	12 studies	29% ± 11%	Explore
conventional dendritic cell	10 studies	34% ± 22%	Explore
innate lymphoid cell	9 studies	45% ± 18%	Explore
effector CD8-positive, alpha-beta T cell	8 studies	30% ± 9%	Explore
leukocyte	8 studies	43% ± 22%	Explore
T follicular helper cell	7 studies	47% ± 17%	Explore
hematopoietic precursor cell	6 studies	40% ± 24%	Explore
plasma cell	6 studies	33% ± 9%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	46% ± 13%	Explore
CD4-positive helper T cell	5 studies	36% ± 15%	Explore
exhausted T cell	5 studies	44% ± 12%	Explore
hematopoietic stem cell	5 studies	25% ± 10%	Explore
lymphocyte	5 studies	57% ± 25%	Explore
precursor B cell	5 studies	30% ± 9%	Explore
pro-B cell	5 studies	33% ± 9%	Explore
immature B cell	5 studies	39% ± 5%	Explore
effector CD4-positive, alpha-beta T cell	5 studies	33% ± 9%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	38% ± 17%	Explore
plasmablast	4 studies	46% ± 24%	Explore
erythrocyte	4 studies	26% ± 8%	Explore
mononuclear phagocyte	4 studies	22% ± 6%	Explore
T-helper 17 cell	4 studies	43% ± 12%	Explore
T-helper 1 cell	4 studies	46% ± 5%	Explore
central memory CD8-positive, alpha-beta T cell	4 studies	36% ± 12%	Explore
double negative thymocyte	4 studies	40% ± 9%	Explore
germinal center B cell	3 studies	34% ± 3%	Explore
granulocyte	3 studies	36% ± 20%	Explore
alveolar macrophage	3 studies	31% ± 12%	Explore
group 3 innate lymphoid cell	3 studies	41% ± 10%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	41% ± 7%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	37% ± 6%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	18 studies	36% ± 15%	Explore
lung	6 studies	19% ± 2%	Explore
bone marrow	4 studies	31% ± 11%	Explore
liver	3 studies	30% ± 5%	Explore
lymph node	3 studies	38% ± 10%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	100%	2282.07	578 / 578	83%	6.58	957 / 1155
breast	91%	520.83	418 / 459	80%	6.09	891 / 1118
stomach	89%	506.24	318 / 359	62%	4.80	177 / 286
prostate	86%	514.26	210 / 245	53%	2.90	268 / 502
esophagus	74%	349.58	1075 / 1445	58%	3.28	106 / 183
intestine	81%	1380.25	785 / 966	50%	3.42	264 / 527
bladder	86%	701.29	18 / 21	46%	2.60	230 / 504
thymus	83%	600.33	545 / 653	46%	9.69	280 / 605
uterus	74%	274.13	125 / 170	51%	2.78	234 / 459
kidney	44%	338.64	39 / 89	72%	5.62	653 / 901
skin	54%	248.97	979 / 1809	58%	6.12	275 / 472
brain	31%	147.98	823 / 2642	70%	3.91	493 / 705
lymph node	0%	0	0 / 0	100%	76.80	29 / 29
peripheral blood	100%	7733.39	929 / 929	0%	0	0 / 0
spleen	100%	8274.39	241 / 241	0%	0	0 / 0
adipose	99%	860.70	1188 / 1204	0%	0	0 / 0
liver	66%	237.87	150 / 226	25%	1.16	101 / 406
adrenal gland	64%	230.41	164 / 258	19%	1.00	44 / 230
pancreas	18%	63.33	59 / 328	64%	5.09	114 / 178
tonsil	0%	0	0 / 0	78%	8.92	35 / 45
ovary	18%	71.28	33 / 180	48%	2.10	206 / 430
blood vessel	58%	347.07	770 / 1335	0%	0	0 / 0
heart	23%	88.25	196 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	14%	0.55	11 / 80
muscle	2%	6.26	15 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0006325	Biological process	chromatin organization
GO_0007498	Biological process	mesoderm development
GO_0030218	Biological process	erythrocyte differentiation
GO_0045892	Biological process	negative regulation of DNA-templated transcription
GO_0030098	Biological process	lymphocyte differentiation
GO_0006357	Biological process	regulation of transcription by RNA polymerase II
GO_0032991	Cellular component	protein-containing complex
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0005721	Cellular component	pericentric heterochromatin
GO_0005634	Cellular component	nucleus
GO_0003677	Molecular function	DNA binding
GO_0000978	Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0003700	Molecular function	DNA-binding transcription factor activity
GO_0019904	Molecular function	protein domain specific binding
GO_0005515	Molecular function	protein binding
GO_0046872	Molecular function	metal ion binding

IV. Literature review

[source]

Gene name	IKZF1
Protein name	IKAROS family zinc finger 1 IKAROS family zinc finger 1 (Zinc finger protein, subfamily 1A, 1 (Ikaros)) IKAROS family zinc finger 1 isoform 14 DNA-binding protein Ikaros (Ikaros family zinc finger protein 1) (Lymphoid transcription factor LyF-1)
Synonyms	IKAROS IK1 LYF1 ZNFN1A1
Description	FUNCTION: Transcription regulator of hematopoietic cell differentiation . Binds gamma-satellite DNA . Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (fikzfterminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single complex (PYR complex), to the beta-globin locus in adult erythrocytes. Increases normal apoptosis in adult erythroid cells. Confers early temporal competence to retinal progenitor cells (RPCs) (By similarity). Function is isoform-specific and is modulated by dominant-negative inactive isoforms . .
Accessions	Q13422 Q3T907 A0A8V8TNQ0 C9JTB0 ENST00000359197.9 [Q13422-7] A0A2R8Y4D3 ENST00000439701.2 [Q13422-7] ENST00000492782.6 ENST00000346667.8 ENST00000413698.5 A0A2R8Y4T7 A0A2R8YFR0 ENST00000438033.5 [Q13422-2] ENST00000642219.2 ENST00000646110.1 ENST00000698575.1 [Q13422-5] ENST00000698573.1 A0A087WU46 ENST00000615491.4 ENST00000331340.8 [Q13422-1] ENST00000645066.1 ENST00000426121.1 A0A8V8TMF3 R9R4D9 ENST00000698574.1 A0A0A0MRA0

IKZF1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review