EIF4E report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0071549Biological processcellular response to dexamethasone stimulus
GO_0099578Biological processregulation of translation at postsynapse, modulating synaptic transmission
GO_0006413Biological processtranslational initiation
GO_0006417Biological processregulation of translation
GO_0006406Biological processmRNA export from nucleus
GO_0045931Biological processpositive regulation of mitotic cell cycle
GO_0030182Biological processneuron differentiation
GO_0045665Biological processnegative regulation of neuron differentiation
GO_0019827Biological processstem cell population maintenance
GO_0010507Biological processnegative regulation of autophagy
GO_0001662Biological processbehavioral fear response
GO_0017148Biological processnegative regulation of translation
GO_0000082Biological processG1/S transition of mitotic cell cycle
GO_0098978Cellular componentglutamatergic synapse
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0036464Cellular componentcytoplasmic ribonucleoprotein granule
GO_0016607Cellular componentnuclear speck
GO_0070062Cellular componentextracellular exosome
GO_0098794Cellular componentpostsynapse
GO_0016281Cellular componenteukaryotic translation initiation factor 4F complex
GO_0000932Cellular componentP-body
GO_0033391Cellular componentchromatoid body
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0016442Cellular componentRISC complex
GO_0010494Cellular componentcytoplasmic stress granule
GO_0005634Cellular componentnucleus
GO_0000339Molecular functionRNA cap binding
GO_0019899Molecular functionenzyme binding
GO_0000340Molecular functionRNA 7-methylguanosine cap binding
GO_0140297Molecular functionDNA-binding transcription factor binding
GO_0031370Molecular functioneukaryotic initiation factor 4G binding
GO_0098808Molecular functionmRNA cap binding
GO_0003743Molecular functiontranslation initiation factor activity
GO_0003723Molecular functionRNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameEIF4E
Protein nameEukaryotic translation initiation factor 4E (eIF-4E) (eIF4E) (eIF-4F 25 kDa subunit) (mRNA cap-binding protein)
Eukaryotic translation initiation factor 4E
SynonymsEIF4F
EIF4EL1
DescriptionFUNCTION: Acts in the cytoplasm to initiate and regulate protein synthesis and is required in the nucleus for export of a subset of mRNAs from the nucleus to the cytoplasm which promotes processes such as RNA capping, processing and splicing . Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (By similarity). This protein recognizes and binds the 7-methylguanosine (m7G)-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures . Together with EIF4G1, antagonizes the scanning promoted by EIF1-EIF4G1 and is required for TISU translation, a process where the TISU element recognition makes scanning unnecessary . In addition to its role in translation initiation, also acts as a regulator of translation and stability in the cytoplasm . Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression: in the complex, EIF4E mediates the binding to the mRNA cap (By similarity). Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity). In P-bodies, component of a complex that mediates the storage of translationally inactive mRNAs in the cytoplasm and prevents their degradation . May play an important role in spermatogenesis through translational regulation of stage-specific mRNAs during germ cell development (By similarity). As well as its roles in translation, also involved in mRNA nucleocytoplasmic transport (By similarity). Its role in mRNA export from the nucleus to the cytoplasm relies on its ability to bind the m7G cap of RNAs and on the presence of the 50-nucleotide EIF4E sensitivity element (4ESE) in the 3'UTR of sensitive transcripts (By similarity). Interaction with the 4ESE is mediated by LRPPRC which binds simultaneously to both EIF4E and the 4ESE, thereby acting as a platform for assembly for the RNA export complex (By similarity). EIF4E-dependent mRNA export is independent of ongoing protein or RNA synthesis and is also NFX1-independent but is XPO1-dependent with LRPPRC interacting with XPO1 to form an EIF4E-dependent mRNA export complex (By similarity). Alters the composition of the cytoplasmic face of the nuclear pore to promote RNA export by reducing RANBP2 expression, relocalizing nucleoporin NUP214 and increasing expression of RANBP1 and RNA export factors DDX19 and GLE1 (By similarity). Promotes the nuclear export of cyclin CCND1 mRNA (By similarity). Promotes the nuclear export of NOS2/iNOS mRNA . Promotes the nuclear export of MDM2 mRNA . Promotes the export of additional mRNAs, including others involved in the cell cycle (By similarity). In the nucleus, binds to capped splice factor-encoding mRNAs and stimulates their nuclear export to enhance splice factor production by increasing their cytoplasmic availability to the translation machinery (By similarity). May also regulate splicing through interaction with the spliceosome in an RNA and m7G cap-dependent manner (By similarity). Also binds to some pre-mRNAs and may play a role in their recruitment to the spliceosome (By similarity). Promotes steady-state capping of a subset of coding and non-coding RNAs by mediating nuclear export of capping machinery mRNAs including RNMT, RNGTT and RAMAC to enhance their translation (By similarity). Stimulates mRNA 3'-end processing by promoting the expression of several core cleavage complex factors required for mRNA cleavage and polyadenylation, and may also have a direct effect through its interaction with the CPSF3 cleavage enzyme (By similarity). Rescues cells from apoptosis by promoting activation of serine/threonine-protein kinase AKT1 through mRNA export of NBS1 which potentiates AKT1 phosphorylation and also through mRNA export of AKT1 effectors, allowing for increased production of these proteins (By similarity). .

AccessionsENST00000515638.5
P06730
ENST00000505992.1 [P06730-2]
ENST00000511644.5
D6RFJ3
ENST00000280892.10 [P06730-3]
ENST00000504432.5
ENST00000450253.7 [P06730-1]
Q32Q75
X5D7E3
D6RBW1
H0Y8J7