DYNLT1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0000132Biological processestablishment of mitotic spindle orientation
GO_0051301Biological processcell division
GO_0046718Biological processsymbiont entry into host cell
GO_0008277Biological processregulation of G protein-coupled receptor signaling pathway
GO_0019060Biological processintracellular transport of viral protein in host cell
GO_0007018Biological processmicrotubule-based movement
GO_0075521Biological processmicrotubule-dependent intracellular transport of viral material towards nucleus
GO_0007399Biological processnervous system development
GO_0050768Biological processnegative regulation of neurogenesis
GO_0005576Cellular componentextracellular region
GO_0005868Cellular componentcytoplasmic dynein complex
GO_0005794Cellular componentGolgi apparatus
GO_0030286Cellular componentdynein complex
GO_0034774Cellular componentsecretory granule lumen
GO_0099503Cellular componentsecretory vesicle
GO_1904813Cellular componentficolin-1-rich granule lumen
GO_0005881Cellular componentcytoplasmic microtubule
GO_0005737Cellular componentcytoplasm
GO_0043657Cellular componenthost cell
GO_0005819Cellular componentspindle
GO_0042802Molecular functionidentical protein binding
GO_0045505Molecular functiondynein intermediate chain binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameDYNLT1
Protein nameDynein light chain Tctex-type 1 (Protein CW-1) (T-complex testis-specific protein 1 homolog)
SynonymsTCTEX-1
TCTEX1
TCTEL1
DescriptionFUNCTION: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Binds to transport cargos and is involved in apical cargo transport such as rhodopsin-bearing vesicles in polarized epithelia. May also be a accessory component of axonemal dynein.; FUNCTION: Plays a role in neuronal morphogenesis; the function is independent of cytoplasmic dynein and seems to be coupled to regulation of the actin cytoskeleton by enhancing Rac1 activity. The function in neurogenesis may be regulated by association with a G-protein beta-gamma dimer. May function as a receptor-independent activator of heterotrimeric G-protein signaling; the activation appears to be independent of a nucleotide exchange. Plays a role in regulating neurogenesis; inhibits the genesis of neurons from precursor cells during cortical development presumably by antagonizing ARHGEF2. Involved in the regulation of mitotic spindle orientation (By similarity). Unrelated to the role in retrograde microtubule-associated movement may play a role in the dimerization of cytoplasmic proteins/domains such as for ACVR2B. Binds to the cytoplasmic domain of ACVR2B and, in vitro, inhibits ACVR2B signaling . .; FUNCTION: (Microbial infection) Is involved in intracellular targeting of D-type retrovirus gag polyproteins to the cytoplasmic assembly site. .

AccessionsP63172
ENST00000367089.8