DIAPH1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007605Biological processsensory perception of sound
GO_0071420Biological processcellular response to histamine
GO_0032886Biological processregulation of microtubule-based process
GO_0051493Biological processregulation of cytoskeleton organization
GO_0030041Biological processactin filament polymerization
GO_0007010Biological processcytoskeleton organization
GO_0030036Biological processactin cytoskeleton organization
GO_0035372Biological processprotein localization to microtubule
GO_0051279Biological processregulation of release of sequestered calcium ion into cytosol
GO_0008360Biological processregulation of cell shape
GO_0032587Cellular componentruffle membrane
GO_0030667Cellular componentsecretory granule membrane
GO_0005886Cellular componentplasma membrane
GO_0072686Cellular componentmitotic spindle
GO_0005813Cellular componentcentrosome
GO_0005884Cellular componentactin filament
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0101003Cellular componentficolin-1-rich granule membrane
GO_0005634Cellular componentnucleus
GO_0005102Molecular functionsignaling receptor binding
GO_0031267Molecular functionsmall GTPase binding
GO_0044325Molecular functiontransmembrane transporter binding
GO_0003723Molecular functionRNA binding
GO_0005515Molecular functionprotein binding
GO_0003779Molecular functionactin binding

IV. Literature review

[source]
Gene nameDIAPH1
Protein nameDiaphanous homolog 1
Diaphanous-1
Protein diaphanous homolog 1 (Diaphanous-related formin-1) (DRF1)
Diaphanous related formin 1
DIAPH1 protein
Diaphanous related formin 1 (cDNA FLJ61549, highly similar to Protein diaphanous homolog 1)
SynonymsDIA1
DIAP1
DescriptionFUNCTION: Actin nucleation and elongation factor required for the assembly of F-actin structures, such as actin cables and stress fibers (By similarity). Binds to the barbed end of the actin filament and slows down actin polymerization and depolymerization (By similarity). Required for cytokinesis, and transcriptional activation of the serum response factor (By similarity). DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics (By similarity). Functions as a scaffold protein for MAPRE1 and APC to stabilize microtubules and promote cell migration (By similarity). Has neurite outgrowth promoting activity. Acts in a Rho-dependent manner to recruit PFY1 to the membrane (By similarity). In hear cells, it may play a role in the regulation of actin polymerization in hair cells . The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex . It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity . In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization . Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape . Plays a role in brain development . Also acts as an actin nucleation and elongation factor in the nucleus by promoting nuclear actin polymerization inside the nucleus to drive serum-dependent SRF-MRTFA activity (By similarity). .

AccessionsENST00000389054.8 [O60610-1]
ENST00000518047.5 [O60610-3]
A0RZB7
A0RZB8
B4E2I7
ENST00000468119.3
Q96IL1
ENST00000647433.1
A0A2R8YEF8
A0A1E1ERW3
ENST00000647330.1
ENST00000448451.6
O60610
A0A2R8Y5N1
H7C2W8
ENST00000643312.1
ENST00000523100.5