DDX6 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	35 studies	30% ± 13%	Explore
natural killer cell	35 studies	33% ± 13%	Explore
T cell	29 studies	28% ± 11%	Explore
endothelial cell	28 studies	26% ± 9%	Explore
CD8-positive, alpha-beta T cell	27 studies	31% ± 14%	Explore
CD4-positive, alpha-beta T cell	25 studies	30% ± 15%	Explore
fibroblast	22 studies	23% ± 8%	Explore
memory B cell	20 studies	30% ± 8%	Explore
pericyte	19 studies	22% ± 7%	Explore
smooth muscle cell	19 studies	21% ± 5%	Explore
naive B cell	19 studies	32% ± 8%	Explore
regulatory T cell	19 studies	33% ± 8%	Explore
macrophage	18 studies	22% ± 6%	Explore
mature NK T cell	17 studies	32% ± 10%	Explore
CD16-positive, CD56-dim natural killer cell, human	16 studies	41% ± 15%	Explore
gamma-delta T cell	16 studies	38% ± 12%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	15 studies	33% ± 12%	Explore
CD16-negative, CD56-bright natural killer cell, human	15 studies	37% ± 12%	Explore
plasmacytoid dendritic cell	14 studies	27% ± 9%	Explore
mucosal invariant T cell	14 studies	33% ± 10%	Explore
mast cell	12 studies	23% ± 9%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	12 studies	36% ± 13%	Explore
CD8-positive, alpha-beta memory T cell	11 studies	39% ± 11%	Explore
ciliated cell	11 studies	28% ± 11%	Explore
non-classical monocyte	11 studies	30% ± 17%	Explore
effector memory CD8-positive, alpha-beta T cell	11 studies	39% ± 17%	Explore
astrocyte	11 studies	25% ± 10%	Explore
oligodendrocyte	11 studies	28% ± 11%	Explore
glutamatergic neuron	10 studies	34% ± 21%	Explore
microglial cell	10 studies	28% ± 10%	Explore
dendritic cell	9 studies	37% ± 24%	Explore
monocyte	9 studies	23% ± 3%	Explore
type I pneumocyte	9 studies	23% ± 5%	Explore
CD4-positive, alpha-beta memory T cell	9 studies	33% ± 8%	Explore
epithelial cell	9 studies	34% ± 21%	Explore
myofibroblast cell	9 studies	22% ± 7%	Explore
endothelial cell of lymphatic vessel	8 studies	26% ± 3%	Explore
basal cell	8 studies	30% ± 12%	Explore
GABAergic neuron	8 studies	35% ± 17%	Explore
plasma cell	7 studies	26% ± 14%	Explore
capillary endothelial cell	7 studies	18% ± 3%	Explore
neuron	7 studies	26% ± 9%	Explore
interneuron	7 studies	40% ± 19%	Explore
T follicular helper cell	7 studies	31% ± 10%	Explore
oligodendrocyte precursor cell	7 studies	27% ± 11%	Explore
classical monocyte	6 studies	31% ± 14%	Explore
leukocyte	6 studies	32% ± 8%	Explore
conventional dendritic cell	6 studies	31% ± 21%	Explore
connective tissue cell	6 studies	22% ± 4%	Explore
abnormal cell	6 studies	26% ± 9%	Explore
lymphocyte	6 studies	33% ± 14%	Explore
precursor B cell	6 studies	29% ± 6%	Explore
myeloid cell	6 studies	26% ± 10%	Explore
retinal rod cell	6 studies	21% ± 4%	Explore
secretory cell	5 studies	24% ± 9%	Explore
plasmablast	5 studies	39% ± 19%	Explore
effector CD8-positive, alpha-beta T cell	5 studies	30% ± 5%	Explore
progenitor cell	5 studies	18% ± 2%	Explore
endothelial cell of artery	5 studies	18% ± 4%	Explore
pro-B cell	5 studies	24% ± 2%	Explore
innate lymphoid cell	5 studies	30% ± 8%	Explore
club cell	5 studies	26% ± 8%	Explore
amacrine cell	5 studies	29% ± 11%	Explore
adipocyte	5 studies	22% ± 7%	Explore
cardiac muscle cell	5 studies	20% ± 3%	Explore
vein endothelial cell	5 studies	22% ± 9%	Explore
Mueller cell	5 studies	24% ± 4%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	39% ± 17%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	33% ± 5%	Explore
exhausted T cell	4 studies	42% ± 18%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	30% ± 6%	Explore
mononuclear phagocyte	4 studies	19% ± 3%	Explore
retinal bipolar neuron	4 studies	25% ± 7%	Explore
brush cell	4 studies	32% ± 8%	Explore
immature B cell	4 studies	34% ± 6%	Explore
type II pneumocyte	4 studies	22% ± 4%	Explore
retina horizontal cell	4 studies	27% ± 7%	Explore
endothelial cell of vascular tree	4 studies	24% ± 9%	Explore
double negative thymocyte	4 studies	47% ± 11%	Explore
hematopoietic precursor cell	3 studies	39% ± 25%	Explore
ionocyte	3 studies	29% ± 7%	Explore
GABAergic interneuron	3 studies	23% ± 2%	Explore
glial cell	3 studies	20% ± 1%	Explore
squamous epithelial cell	3 studies	42% ± 26%	Explore
retinal cone cell	3 studies	26% ± 5%	Explore
tissue-resident macrophage	3 studies	19% ± 3%	Explore
rod bipolar cell	3 studies	29% ± 6%	Explore
germinal center B cell	3 studies	24% ± 2%	Explore
CD4-positive helper T cell	3 studies	35% ± 11%	Explore
neural progenitor cell	3 studies	32% ± 12%	Explore
granulocyte	3 studies	26% ± 8%	Explore
group 3 innate lymphoid cell	3 studies	40% ± 10%	Explore
goblet cell	3 studies	35% ± 18%	Explore
transit amplifying cell	3 studies	30% ± 17%	Explore
T-helper 17 cell	3 studies	28% ± 4%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	34% ± 4%	Explore
central memory CD8-positive, alpha-beta T cell	3 studies	31% ± 6%	Explore
double-positive, alpha-beta thymocyte	3 studies	49% ± 10%	Explore
hematopoietic stem cell	3 studies	17% ± 2%	Explore
mural cell	3 studies	33% ± 14%	Explore
enteroendocrine cell	3 studies	20% ± 4%	Explore
erythrocyte	3 studies	31% ± 9%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	17 studies	34% ± 14%	Explore
brain	17 studies	30% ± 16%	Explore
lung	9 studies	28% ± 9%	Explore
eye	7 studies	27% ± 11%	Explore
heart	5 studies	18% ± 2%	Explore
intestine	5 studies	20% ± 3%	Explore
kidney	4 studies	20% ± 2%	Explore
bone marrow	4 studies	24% ± 5%	Explore
uterus	4 studies	27% ± 9%	Explore
liver	4 studies	25% ± 7%	Explore
adipose	4 studies	23% ± 3%	Explore
lymph node	3 studies	27% ± 8%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	6375.80	2642 / 2642	100%	57.30	705 / 705
esophagus	100%	6630.18	1445 / 1445	100%	40.95	183 / 183
lung	100%	6282.02	578 / 578	100%	45.85	1155 / 1155
prostate	100%	6296.94	245 / 245	100%	52.74	502 / 502
breast	100%	6222.09	459 / 459	100%	61.49	1117 / 1118
bladder	100%	6598.76	21 / 21	100%	35.70	503 / 504
thymus	100%	6094.38	653 / 653	100%	48.79	603 / 605
uterus	100%	7161.61	170 / 170	100%	35.77	457 / 459
ovary	100%	8602.53	180 / 180	100%	29.88	428 / 430
pancreas	100%	3827.32	328 / 328	99%	38.20	177 / 178
stomach	100%	4519.81	359 / 359	99%	36.07	283 / 286
kidney	100%	3879.81	89 / 89	99%	38.77	891 / 901
intestine	100%	6861.51	966 / 966	98%	33.90	518 / 527
skin	100%	7296.81	1809 / 1809	97%	39.42	458 / 472
adrenal gland	100%	5033.80	258 / 258	97%	34.61	223 / 230
liver	100%	2519.67	226 / 226	92%	18.41	373 / 406
blood vessel	100%	6387.47	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	54.12	29 / 29
muscle	100%	5871.60	803 / 803	0%	0	0 / 0
spleen	100%	7327.01	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	34.35	45 / 45
ureter	0%	0	0 / 0	100%	16.40	1 / 1
adipose	100%	6193.23	1203 / 1204	0%	0	0 / 0
peripheral blood	98%	6510.68	913 / 929	0%	0	0 / 0
heart	98%	4767.59	846 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	96%	40.31	77 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0034063	Biological process	stress granule assembly
GO_0035278	Biological process	miRNA-mediated gene silencing by inhibition of translation
GO_0033962	Biological process	P-body assembly
GO_0030182	Biological process	neuron differentiation
GO_0045665	Biological process	negative regulation of neuron differentiation
GO_0019074	Biological process	viral RNA genome packaging
GO_0019827	Biological process	stem cell population maintenance
GO_0017148	Biological process	negative regulation of translation
GO_0016020	Cellular component	membrane
GO_0036464	Cellular component	cytoplasmic ribonucleoprotein granule
GO_0000932	Cellular component	P-body
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0016442	Cellular component	RISC complex
GO_0010494	Cellular component	cytoplasmic stress granule
GO_0005634	Cellular component	nucleus
GO_0004386	Molecular function	helicase activity
GO_0019904	Molecular function	protein domain specific binding
GO_0003724	Molecular function	RNA helicase activity
GO_0045296	Molecular function	cadherin binding
GO_0003729	Molecular function	mRNA binding
GO_0005524	Molecular function	ATP binding
GO_0003723	Molecular function	RNA binding
GO_0005515	Molecular function	protein binding
GO_0016887	Molecular function	ATP hydrolysis activity

IV. Literature review

[source]

Gene name	DDX6
Protein name	Probable ATP-dependent RNA helicase DDX6 (EC 3.6.4.13) (ATP-dependent RNA helicase p54) (DEAD box protein 6) (Oncogene RCK)
Synonyms	HLR2 RCK
Description	FUNCTION: Essential for the formation of P-bodies, cytosolic membrane-less ribonucleoprotein granules involved in RNA metabolism through the coordinated storage of mRNAs encoding regulatory functions . Plays a role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation . In the process of mRNA degradation, plays a role in mRNA decapping . Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts . .
Accessions	ENST00000620157.4 ENST00000526070.2 P26196 ENST00000534980.7

DDX6 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review