CYRIB | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	44 studies	49% ± 16%	Explore
natural killer cell	41 studies	50% ± 14%	Explore
B cell	39 studies	34% ± 10%	Explore
CD8-positive, alpha-beta T cell	34 studies	36% ± 12%	Explore
T cell	33 studies	34% ± 11%	Explore
CD4-positive, alpha-beta T cell	30 studies	32% ± 10%	Explore
conventional dendritic cell	28 studies	60% ± 13%	Explore
dendritic cell	26 studies	50% ± 23%	Explore
regulatory T cell	24 studies	35% ± 7%	Explore
classical monocyte	23 studies	43% ± 12%	Explore
monocyte	22 studies	50% ± 18%	Explore
non-classical monocyte	22 studies	48% ± 13%	Explore
mature NK T cell	21 studies	40% ± 12%	Explore
memory B cell	19 studies	31% ± 7%	Explore
plasmacytoid dendritic cell	19 studies	46% ± 13%	Explore
mast cell	18 studies	26% ± 11%	Explore
naive B cell	18 studies	27% ± 7%	Explore
myeloid cell	17 studies	55% ± 16%	Explore
gamma-delta T cell	16 studies	39% ± 12%	Explore
CD16-negative, CD56-bright natural killer cell, human	15 studies	47% ± 15%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	55% ± 13%	Explore
endothelial cell	15 studies	28% ± 12%	Explore
oligodendrocyte	14 studies	43% ± 15%	Explore
microglial cell	14 studies	66% ± 20%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	13 studies	27% ± 7%	Explore
oligodendrocyte precursor cell	13 studies	47% ± 21%	Explore
mucosal invariant T cell	13 studies	32% ± 8%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	35% ± 12%	Explore
neutrophil	12 studies	45% ± 14%	Explore
glutamatergic neuron	12 studies	56% ± 26%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	28% ± 10%	Explore
leukocyte	11 studies	47% ± 20%	Explore
basal cell	11 studies	38% ± 18%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	10 studies	31% ± 9%	Explore
GABAergic neuron	10 studies	59% ± 25%	Explore
effector memory CD8-positive, alpha-beta T cell	10 studies	39% ± 12%	Explore
epithelial cell	10 studies	39% ± 17%	Explore
adipocyte	9 studies	41% ± 9%	Explore
alveolar macrophage	8 studies	40% ± 22%	Explore
type I pneumocyte	8 studies	37% ± 10%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	36% ± 12%	Explore
mononuclear phagocyte	7 studies	57% ± 15%	Explore
neuron	7 studies	52% ± 23%	Explore
innate lymphoid cell	7 studies	33% ± 10%	Explore
plasma cell	7 studies	33% ± 9%	Explore
club cell	7 studies	28% ± 10%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	6 studies	37% ± 13%	Explore
hematopoietic precursor cell	6 studies	41% ± 20%	Explore
retinal ganglion cell	6 studies	51% ± 15%	Explore
amacrine cell	6 studies	50% ± 18%	Explore
ciliated cell	6 studies	28% ± 13%	Explore
T follicular helper cell	6 studies	31% ± 3%	Explore
type II pneumocyte	6 studies	36% ± 6%	Explore
astrocyte	6 studies	30% ± 11%	Explore
exhausted T cell	5 studies	43% ± 12%	Explore
lymphocyte	5 studies	54% ± 13%	Explore
precursor B cell	5 studies	34% ± 11%	Explore
pro-B cell	5 studies	25% ± 5%	Explore
retina horizontal cell	5 studies	24% ± 6%	Explore
retinal cone cell	5 studies	27% ± 10%	Explore
cardiac muscle cell	5 studies	35% ± 8%	Explore
effector CD4-positive, alpha-beta T cell	5 studies	31% ± 7%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	30% ± 13%	Explore
abnormal cell	5 studies	28% ± 13%	Explore
interneuron	5 studies	62% ± 28%	Explore
CD4-positive, alpha-beta cytotoxic T cell	4 studies	27% ± 10%	Explore
plasmablast	4 studies	45% ± 14%	Explore
secretory cell	4 studies	29% ± 16%	Explore
intermediate monocyte	4 studies	51% ± 20%	Explore
CD4-positive helper T cell	4 studies	24% ± 8%	Explore
respiratory goblet cell	4 studies	35% ± 11%	Explore
fibroblast	4 studies	22% ± 6%	Explore
goblet cell	4 studies	34% ± 23%	Explore
T-helper 17 cell	4 studies	34% ± 6%	Explore
squamous epithelial cell	3 studies	36% ± 25%	Explore
monocyte-derived dendritic cell	3 studies	52% ± 24%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	24% ± 8%	Explore
smooth muscle cell	3 studies	16% ± 1%	Explore
extravillous trophoblast	3 studies	25% ± 11%	Explore
placental villous trophoblast	3 studies	24% ± 5%	Explore
immature B cell	3 studies	33% ± 11%	Explore
retinal pigment epithelial cell	3 studies	23% ± 8%	Explore
tissue-resident macrophage	3 studies	55% ± 9%	Explore
retinal bipolar neuron	3 studies	21% ± 4%	Explore
GABAergic amacrine cell	3 studies	43% ± 10%	Explore
OFF-bipolar cell	3 studies	32% ± 8%	Explore
ON-bipolar cell	3 studies	34% ± 8%	Explore
glycinergic amacrine cell	3 studies	36% ± 5%	Explore
retinal rod cell	3 studies	22% ± 1%	Explore
germinal center B cell	3 studies	45% ± 4%	Explore
cholangiocyte	3 studies	46% ± 18%	Explore
inflammatory macrophage	3 studies	37% ± 11%	Explore
granulocyte	3 studies	34% ± 23%	Explore
group 3 innate lymphoid cell	3 studies	30% ± 14%	Explore
granule cell	3 studies	37% ± 5%	Explore
double negative thymocyte	3 studies	46% ± 6%	Explore
renal principal cell	3 studies	36% ± 15%	Explore
mucus secreting cell	3 studies	27% ± 4%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	18 studies	46% ± 22%	Explore
peripheral blood	16 studies	37% ± 11%	Explore
lung	15 studies	31% ± 13%	Explore
intestine	7 studies	21% ± 6%	Explore
eye	6 studies	25% ± 8%	Explore
kidney	5 studies	28% ± 5%	Explore
heart	5 studies	23% ± 5%	Explore
placenta	4 studies	26% ± 8%	Explore
bone marrow	4 studies	30% ± 9%	Explore
lymph node	4 studies	34% ± 3%	Explore
liver	4 studies	40% ± 8%	Explore
adipose	4 studies	27% ± 5%	Explore
breast	3 studies	20% ± 2%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	100%	1944.19	459 / 459	100%	37.72	1117 / 1118
lung	100%	3246.01	576 / 578	100%	35.99	1155 / 1155
brain	99%	4228.94	2627 / 2642	100%	31.55	705 / 705
bladder	100%	1457.38	21 / 21	99%	29.50	500 / 504
intestine	100%	1769.75	966 / 966	99%	26.03	521 / 527
thymus	100%	1911.70	652 / 653	99%	16.92	598 / 605
esophagus	98%	1548.88	1418 / 1445	100%	31.77	183 / 183
stomach	99%	1270.22	355 / 359	99%	27.85	283 / 286
uterus	98%	1109.68	166 / 170	99%	29.73	453 / 459
kidney	100%	1711.81	89 / 89	96%	15.93	863 / 901
skin	99%	1355.95	1794 / 1809	96%	25.49	453 / 472
prostate	99%	1308.20	243 / 245	95%	10.75	476 / 502
ovary	89%	792.62	160 / 180	100%	31.28	430 / 430
adrenal gland	100%	2103.38	258 / 258	89%	14.71	204 / 230
pancreas	80%	782.78	264 / 328	99%	21.52	176 / 178
liver	82%	739.54	185 / 226	83%	12.42	337 / 406
adipose	100%	2326.36	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	71.04	29 / 29
peripheral blood	100%	11975.45	929 / 929	0%	0	0 / 0
spleen	100%	6493.83	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	28.21	45 / 45
ureter	0%	0	0 / 0	100%	13.40	1 / 1
muscle	100%	1901.46	799 / 803	0%	0	0 / 0
blood vessel	93%	1176.40	1247 / 1335	0%	0	0 / 0
heart	86%	993.80	744 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	74%	12.85	59 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0050870	Biological process	positive regulation of T cell activation
GO_0030837	Biological process	negative regulation of actin filament polymerization
GO_2000114	Biological process	regulation of establishment of cell polarity
GO_0071219	Biological process	cellular response to molecule of bacterial origin
GO_2000568	Biological process	positive regulation of memory T cell activation
GO_0001916	Biological process	positive regulation of T cell mediated cytotoxicity
GO_0030334	Biological process	regulation of cell migration
GO_0050920	Biological process	regulation of chemotaxis
GO_0090140	Biological process	regulation of mitochondrial fission
GO_0032729	Biological process	positive regulation of type II interferon production
GO_0051058	Biological process	negative regulation of small GTPase mediated signal transduction
GO_0005576	Cellular component	extracellular region
GO_0016020	Cellular component	membrane
GO_0005739	Cellular component	mitochondrion
GO_0070062	Cellular component	extracellular exosome
GO_0005929	Cellular component	cilium
GO_0031093	Cellular component	platelet alpha granule lumen
GO_0023030	Molecular function	MHC class Ib protein binding, via antigen binding groove
GO_0031267	Molecular function	small GTPase binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	CYRIB
Protein name	CYFIP related Rac1 interactor B CYFIP-related Rac1 interactor B (L1)
Synonyms	BM-009 FAM49B CYRI
Description	FUNCTION: Negatively regulates RAC1 signaling and RAC1-driven cytoskeletal remodeling . Regulates chemotaxis, cell migration and epithelial polarization by controlling the polarity, plasticity, duration and extent of protrusions. Limits Rac1 mediated activation of the Scar/WAVE complex, focuses protrusion signals and regulates pseudopod complexity by inhibiting Scar/WAVE-induced actin polymerization . Protects against Salmonella bacterial infection. Attenuates processes such as macropinocytosis, phagocytosis and cell migration and restrict sopE-mediated bacterial entry . Restricts also infection mediated by Mycobacterium tuberculosis and Listeria monocytogenes (By similarity). Involved in the regulation of mitochondrial dynamics and oxidative stress . .
Accessions	Q9NUQ9 ENST00000401979.6 [Q9NUQ9-1] ENST00000703342.1 ENST00000518283.5 ENST00000522746.5 [Q9NUQ9-1] E5RK61 ENST00000520204.5 ENST00000523993.5 A0A8V8TMP7 ENST00000699094.1 ENST00000522941.5 [Q9NUQ9-2] ENST00000519020.5 ENST00000518167.5 ENST00000519070.5 E5RIR8 E5RJL8 ENST00000522361.1 E5RI16 E5RH75 E5RHU5 E5RFS4 ENST00000520254.5 E5RK81 ENST00000517672.5 ENST00000519110.5 [Q9NUQ9-1] ENST00000694912.1 [Q9NUQ9-1] ENST00000519824.6 [Q9NUQ9-1] E5RJE1 ENST00000523509.5 [Q9NUQ9-1] ENST00000522250.5 [Q9NUQ9-2] E5RGI7 ENST00000519540.5 [Q9NUQ9-1] ENST00000517654.5 [Q9NUQ9-1] ENST00000519142.5

CYRIB report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review