COTL1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	46 studies	55% ± 23%	Explore
B cell	37 studies	49% ± 19%	Explore
CD8-positive, alpha-beta T cell	36 studies	45% ± 19%	Explore
T cell	33 studies	48% ± 22%	Explore
conventional dendritic cell	31 studies	81% ± 19%	Explore
CD4-positive, alpha-beta T cell	30 studies	47% ± 16%	Explore
dendritic cell	29 studies	69% ± 22%	Explore
classical monocyte	29 studies	84% ± 10%	Explore
monocyte	28 studies	71% ± 20%	Explore
regulatory T cell	28 studies	46% ± 19%	Explore
non-classical monocyte	27 studies	92% ± 10%	Explore
endothelial cell	20 studies	32% ± 13%	Explore
memory B cell	20 studies	61% ± 17%	Explore
natural killer cell	19 studies	39% ± 21%	Explore
naive B cell	17 studies	36% ± 10%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	17 studies	33% ± 11%	Explore
neutrophil	16 studies	58% ± 19%	Explore
gamma-delta T cell	16 studies	36% ± 19%	Explore
CD16-negative, CD56-bright natural killer cell, human	15 studies	48% ± 19%	Explore
myeloid cell	15 studies	62% ± 18%	Explore
mast cell	14 studies	29% ± 6%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	13 studies	40% ± 13%	Explore
microglial cell	13 studies	42% ± 20%	Explore
mature NK T cell	12 studies	33% ± 18%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	51% ± 18%	Explore
CD8-positive, alpha-beta memory T cell	11 studies	53% ± 19%	Explore
endothelial cell of lymphatic vessel	10 studies	34% ± 15%	Explore
plasma cell	10 studies	38% ± 20%	Explore
plasmablast	10 studies	49% ± 20%	Explore
platelet	10 studies	49% ± 21%	Explore
T follicular helper cell	10 studies	64% ± 20%	Explore
effector memory CD8-positive, alpha-beta T cell	10 studies	36% ± 14%	Explore
fibroblast	10 studies	25% ± 8%	Explore
vein endothelial cell	10 studies	30% ± 19%	Explore
leukocyte	9 studies	53% ± 20%	Explore
mucosal invariant T cell	9 studies	26% ± 7%	Explore
epithelial cell	9 studies	30% ± 10%	Explore
plasmacytoid dendritic cell	8 studies	33% ± 16%	Explore
effector CD8-positive, alpha-beta T cell	8 studies	40% ± 16%	Explore
mononuclear phagocyte	8 studies	61% ± 27%	Explore
retinal cone cell	8 studies	50% ± 27%	Explore
innate lymphoid cell	8 studies	35% ± 17%	Explore
astrocyte	8 studies	28% ± 12%	Explore
endothelial cell of vascular tree	8 studies	29% ± 7%	Explore
alveolar macrophage	7 studies	56% ± 13%	Explore
oligodendrocyte precursor cell	7 studies	29% ± 9%	Explore
abnormal cell	7 studies	27% ± 14%	Explore
CD4-positive helper T cell	6 studies	38% ± 14%	Explore
hematopoietic precursor cell	6 studies	50% ± 21%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	33% ± 5%	Explore
CD16-positive, CD56-dim natural killer cell, human	6 studies	30% ± 22%	Explore
intermediate monocyte	6 studies	86% ± 11%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	45% ± 12%	Explore
CD4-positive, alpha-beta cytotoxic T cell	5 studies	43% ± 21%	Explore
central memory CD8-positive, alpha-beta T cell	5 studies	37% ± 13%	Explore
exhausted T cell	5 studies	56% ± 22%	Explore
capillary endothelial cell	5 studies	29% ± 12%	Explore
epithelial cell of proximal tubule	5 studies	35% ± 13%	Explore
transit amplifying cell	5 studies	28% ± 7%	Explore
connective tissue cell	5 studies	37% ± 22%	Explore
neuron	5 studies	19% ± 4%	Explore
granulocyte	5 studies	38% ± 11%	Explore
pancreatic A cell	4 studies	41% ± 11%	Explore
intestinal crypt stem cell	4 studies	26% ± 8%	Explore
myofibroblast cell	4 studies	28% ± 13%	Explore
pericyte	4 studies	24% ± 5%	Explore
smooth muscle cell	4 studies	46% ± 19%	Explore
lymphocyte	4 studies	36% ± 20%	Explore
immature B cell	4 studies	42% ± 23%	Explore
progenitor cell	4 studies	33% ± 18%	Explore
retinal pigment epithelial cell	4 studies	43% ± 16%	Explore
double negative thymocyte	4 studies	50% ± 29%	Explore
germinal center B cell	4 studies	69% ± 17%	Explore
megakaryocyte-erythroid progenitor cell	4 studies	47% ± 17%	Explore
enteroendocrine cell	4 studies	26% ± 3%	Explore
basal cell	4 studies	24% ± 9%	Explore
group 3 innate lymphoid cell	4 studies	48% ± 19%	Explore
T-helper 17 cell	4 studies	51% ± 10%	Explore
T-helper 1 cell	4 studies	54% ± 16%	Explore
monocyte-derived dendritic cell	3 studies	85% ± 17%	Explore
extravillous trophoblast	3 studies	91% ± 5%	Explore
placental villous trophoblast	3 studies	33% ± 7%	Explore
common myeloid progenitor	3 studies	30% ± 3%	Explore
megakaryocyte	3 studies	59% ± 18%	Explore
precursor B cell	3 studies	36% ± 26%	Explore
tissue-resident macrophage	3 studies	61% ± 26%	Explore
ciliated cell	3 studies	25% ± 5%	Explore
intraepithelial lymphocyte	3 studies	45% ± 14%	Explore
endothelial cell of sinusoid	3 studies	39% ± 21%	Explore
inflammatory macrophage	3 studies	66% ± 10%	Explore
GABAergic neuron	3 studies	25% ± 7%	Explore
hematopoietic stem cell	3 studies	36% ± 13%	Explore
erythroblast	3 studies	26% ± 11%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	30% ± 8%	Explore
secretory cell	3 studies	30% ± 5%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	21 studies	48% ± 15%	Explore
lung	16 studies	33% ± 12%	Explore
intestine	11 studies	25% ± 6%	Explore
kidney	7 studies	29% ± 11%	Explore
lymph node	6 studies	45% ± 11%	Explore
liver	6 studies	28% ± 12%	Explore
placenta	5 studies	35% ± 19%	Explore
brain	5 studies	34% ± 13%	Explore
bone marrow	4 studies	37% ± 12%	Explore
pancreas	3 studies	26% ± 7%	Explore
eye	3 studies	32% ± 6%	Explore
uterus	3 studies	39% ± 17%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	99%	4492.89	2624 / 2642	100%	102.24	705 / 705
intestine	100%	5502.03	964 / 966	98%	78.37	518 / 527
lung	100%	8814.45	577 / 578	98%	74.80	1132 / 1155
stomach	100%	7491.80	358 / 359	98%	89.54	279 / 286
prostate	98%	3920.41	241 / 245	98%	51.29	494 / 502
bladder	100%	5806.14	21 / 21	96%	84.38	484 / 504
thymus	96%	3362.25	624 / 653	99%	54.25	600 / 605
breast	99%	4612.50	453 / 459	96%	69.38	1073 / 1118
uterus	97%	3644.61	165 / 170	98%	79.55	448 / 459
kidney	100%	9040.04	89 / 89	92%	71.22	833 / 901
esophagus	73%	1843.25	1049 / 1445	96%	63.79	176 / 183
skin	59%	6509.63	1071 / 1809	100%	156.26	470 / 472
ovary	65%	1622.54	117 / 180	92%	39.92	396 / 430
adrenal gland	96%	2875.90	248 / 258	57%	19.67	132 / 230
pancreas	31%	671.20	102 / 328	97%	109.51	172 / 178
lymph node	0%	0	0 / 0	100%	435.07	29 / 29
peripheral blood	100%	59828.64	929 / 929	0%	0	0 / 0
spleen	100%	27148.92	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	34.46	1 / 1
adipose	100%	6850.12	1202 / 1204	0%	0	0 / 0
tonsil	0%	0	0 / 0	98%	82.39	44 / 45
blood vessel	84%	2551.86	1124 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	81%	34.15	65 / 80
liver	32%	841.21	73 / 226	43%	17.87	174 / 406
heart	33%	768.58	283 / 861	0%	0	0 / 0
muscle	4%	66.91	30 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0050832	Biological process	defense response to fungus
GO_0030833	Biological process	regulation of actin filament polymerization
GO_0008150	Biological process	biological_process
GO_0034774	Cellular component	secretory granule lumen
GO_1904813	Cellular component	ficolin-1-rich granule lumen
GO_0070062	Cellular component	extracellular exosome
GO_0005829	Cellular component	cytosol
GO_0005576	Cellular component	extracellular region
GO_0030864	Cellular component	cortical actin cytoskeleton
GO_0030427	Cellular component	site of polarized growth
GO_0005884	Cellular component	actin filament
GO_0005634	Cellular component	nucleus
GO_0019899	Molecular function	enzyme binding
GO_0051015	Molecular function	actin filament binding
GO_0005515	Molecular function	protein binding
GO_0003779	Molecular function	actin binding

Gene name	COTL1
Protein name	Coactosin-like protein Coactosin like F-actin binding protein 1
Synonyms	CLP
Description	FUNCTION: Binds to F-actin in a calcium-independent manner. Has no direct effect on actin depolymerization. Acts as a chaperone for ALOX5 (5LO), influencing both its stability and activity in leukotrienes synthesis. .
Accessions	ENST00000564057.1 ENST00000567786.2 ENST00000262428.5 A0A087WWC7 H3BT58 Q14019

COTL1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review