BRD4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006325Biological processchromatin organization
GO_0010971Biological processpositive regulation of G2/M transition of mitotic cell cycle
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0006974Biological processDNA damage response
GO_0050727Biological processregulation of inflammatory response
GO_0032968Biological processpositive regulation of transcription elongation by RNA polymerase II
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_2000330Biological processpositive regulation of T-helper 17 cell lineage commitment
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005654Cellular componentnucleoplasm
GO_0000794Cellular componentcondensed nuclear chromosome
GO_0005634Cellular componentnucleus
GO_0019899Molecular functionenzyme binding
GO_0003682Molecular functionchromatin binding
GO_0000976Molecular functiontranscription cis-regulatory region binding
GO_0070577Molecular functionlysine-acetylated histone binding
GO_0003712Molecular functiontranscription coregulator activity
GO_0106140Molecular functionP-TEFb complex binding
GO_0140566Molecular functionhistone reader activity
GO_0008353Molecular functionRNA polymerase II CTD heptapeptide repeat kinase activity
GO_0002039Molecular functionp53 binding
GO_0099122Molecular functionRNA polymerase II C-terminal domain binding
GO_0003713Molecular functiontranscription coactivator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameBRD4
Protein nameBromodomain-containing protein 4 variant
Bromodomain containing 4
BRD4 protein
Bromodomain-containing protein 4 (Protein HUNK1)
SynonymsHUNK1
HUNKI
hCG_2000917
MCAP
CAP
DescriptionFUNCTION: Chromatin reader protein that recognizes and binds acetylated histones and plays a key role in transmission of epigenetic memory across cell divisions and transcription regulation . Remains associated with acetylated chromatin throughout the entire cell cycle and provides epigenetic memory for postmitotic G1 gene transcription by preserving acetylated chromatin status and maintaining high-order chromatin structure . During interphase, plays a key role in regulating the transcription of signal-inducible genes by associating with the P-TEFb complex and recruiting it to promoters . Also recruits P-TEFb complex to distal enhancers, so called anti-pause enhancers in collaboration with JMJD6 . BRD4 and JMJD6 are required to form the transcriptionally active P-TEFb complex by displacing negative regulators such as HEXIM1 and 7SKsnRNA complex from P-TEFb, thereby transforming it into an active form that can then phosphorylate the C-terminal domain (CTD) of RNA polymerase II . Regulates differentiation of naive CD4(+) T-cells into T-helper Th17 by promoting recruitment of P-TEFb to promoters (By similarity). Promotes phosphorylation of 'Ser-2' of the C-terminal domain (CTD) of RNA polymerase II . According to a report, directly acts as an atypical protein kinase and mediates phosphorylation of 'Ser-2' of the C-terminal domain (CTD) of RNA polymerase II; these data however need additional evidences in vivo . In addition to acetylated histones, also recognizes and binds acetylated RELA, leading to further recruitment of the P-TEFb complex and subsequent activation of NF-kappa-B . Also acts as a regulator of p53/TP53-mediated transcription: following phosphorylation by CK2, recruited to p53/TP53 specific target promoters . .; FUNCTION: [Isoform B]: Acts as a chromatin insulator in the DNA damage response pathway. Inhibits DNA damage response signaling by recruiting the condensin-2 complex to acetylated histones, leading to chromatin structure remodeling, insulating the region from DNA damage response by limiting spreading of histone H2AX/H2A.x phosphorylation. .

AccessionsQ5BJ26
ENST00000597315.5
ENST00000679869.1 [O60885-1]
ENST00000371835.8 [O60885-2]
Q05BM2
Q6PIS5
M0QZD9
ENST00000360016.9 [O60885-3]
ENST00000601941.1
ENST00000594841.5
O60885
M0QYW0
Q6NXE4
W8JJB1
ENST00000263377.6 [O60885-1]
M0R0H4