ANAPC5 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	29 studies	26% ± 7%	Explore
fibroblast	27 studies	22% ± 7%	Explore
B cell	24 studies	24% ± 7%	Explore
endothelial cell	24 studies	26% ± 11%	Explore
CD8-positive, alpha-beta T cell	21 studies	26% ± 6%	Explore
CD4-positive, alpha-beta T cell	20 studies	24% ± 7%	Explore
regulatory T cell	19 studies	25% ± 6%	Explore
ciliated cell	18 studies	33% ± 13%	Explore
T cell	17 studies	23% ± 5%	Explore
memory B cell	16 studies	22% ± 5%	Explore
pericyte	16 studies	19% ± 5%	Explore
endothelial cell of lymphatic vessel	15 studies	26% ± 6%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	26% ± 7%	Explore
naive B cell	15 studies	21% ± 4%	Explore
oligodendrocyte	15 studies	37% ± 16%	Explore
gamma-delta T cell	15 studies	26% ± 12%	Explore
plasmacytoid dendritic cell	14 studies	31% ± 9%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	14 studies	22% ± 5%	Explore
plasma cell	13 studies	34% ± 10%	Explore
CD16-negative, CD56-bright natural killer cell, human	13 studies	25% ± 6%	Explore
smooth muscle cell	13 studies	19% ± 3%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	12 studies	26% ± 6%	Explore
mature NK T cell	12 studies	23% ± 4%	Explore
CD8-positive, alpha-beta memory T cell	10 studies	25% ± 8%	Explore
connective tissue cell	10 studies	21% ± 6%	Explore
plasmablast	9 studies	47% ± 23%	Explore
CD4-positive, alpha-beta memory T cell	9 studies	25% ± 4%	Explore
non-classical monocyte	9 studies	25% ± 13%	Explore
macrophage	9 studies	24% ± 6%	Explore
mucosal invariant T cell	9 studies	25% ± 5%	Explore
myofibroblast cell	9 studies	23% ± 4%	Explore
oligodendrocyte precursor cell	9 studies	24% ± 9%	Explore
epithelial cell	8 studies	40% ± 19%	Explore
dendritic cell	8 studies	30% ± 19%	Explore
adipocyte	8 studies	19% ± 4%	Explore
basal cell	7 studies	33% ± 16%	Explore
platelet	7 studies	25% ± 6%	Explore
classical monocyte	7 studies	26% ± 12%	Explore
conventional dendritic cell	7 studies	28% ± 17%	Explore
effector memory CD8-positive, alpha-beta T cell	7 studies	26% ± 7%	Explore
capillary endothelial cell	7 studies	17% ± 2%	Explore
abnormal cell	7 studies	33% ± 11%	Explore
glutamatergic neuron	7 studies	36% ± 23%	Explore
interneuron	7 studies	32% ± 19%	Explore
microglial cell	7 studies	22% ± 6%	Explore
astrocyte	7 studies	26% ± 9%	Explore
monocyte	7 studies	20% ± 3%	Explore
hematopoietic precursor cell	6 studies	35% ± 11%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	25% ± 9%	Explore
hematopoietic stem cell	6 studies	27% ± 4%	Explore
lymphocyte	6 studies	27% ± 7%	Explore
T follicular helper cell	6 studies	21% ± 3%	Explore
GABAergic neuron	6 studies	36% ± 18%	Explore
goblet cell	6 studies	27% ± 10%	Explore
neuron	5 studies	28% ± 12%	Explore
progenitor cell	5 studies	22% ± 6%	Explore
precursor B cell	5 studies	28% ± 6%	Explore
pro-B cell	5 studies	29% ± 3%	Explore
endothelial cell of artery	5 studies	18% ± 1%	Explore
vein endothelial cell	5 studies	24% ± 12%	Explore
endothelial cell of vascular tree	5 studies	22% ± 8%	Explore
type I pneumocyte	5 studies	22% ± 5%	Explore
secretory cell	4 studies	24% ± 3%	Explore
leukocyte	4 studies	23% ± 6%	Explore
exhausted T cell	4 studies	30% ± 6%	Explore
IgG plasma cell	4 studies	20% ± 4%	Explore
glial cell	4 studies	23% ± 11%	Explore
myeloid cell	4 studies	25% ± 9%	Explore
immature B cell	4 studies	23% ± 4%	Explore
retina horizontal cell	4 studies	24% ± 7%	Explore
mesothelial cell	4 studies	21% ± 4%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	28% ± 7%	Explore
innate lymphoid cell	4 studies	23% ± 5%	Explore
type II pneumocyte	4 studies	23% ± 8%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	29% ± 8%	Explore
enteroendocrine cell	4 studies	32% ± 12%	Explore
mast cell	4 studies	19% ± 3%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	23% ± 5%	Explore
ionocyte	3 studies	24% ± 4%	Explore
respiratory goblet cell	3 studies	25% ± 8%	Explore
pancreatic A cell	3 studies	36% ± 13%	Explore
type B pancreatic cell	3 studies	40% ± 9%	Explore
neural crest cell	3 studies	19% ± 1%	Explore
common myeloid progenitor	3 studies	32% ± 17%	Explore
erythroblast	3 studies	46% ± 11%	Explore
megakaryocyte	3 studies	28% ± 8%	Explore
germinal center B cell	3 studies	21% ± 2%	Explore
muscle cell	3 studies	24% ± 6%	Explore
granulocyte monocyte progenitor cell	3 studies	31% ± 7%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	40% ± 25%	Explore
intestinal crypt stem cell	3 studies	24% ± 2%	Explore
club cell	3 studies	25% ± 4%	Explore
group 3 innate lymphoid cell	3 studies	27% ± 10%	Explore
transit amplifying cell	3 studies	42% ± 30%	Explore
hepatocyte	3 studies	35% ± 14%	Explore
T-helper 1 cell	3 studies	22% ± 5%	Explore
T-helper 17 cell	3 studies	21% ± 4%	Explore
double negative thymocyte	3 studies	40% ± 14%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	17 studies	28% ± 18%	Explore
peripheral blood	14 studies	27% ± 8%	Explore
lung	12 studies	22% ± 6%	Explore
intestine	6 studies	21% ± 9%	Explore
lymph node	5 studies	19% ± 1%	Explore
kidney	4 studies	18% ± 3%	Explore
bone marrow	4 studies	22% ± 4%	Explore
adipose	4 studies	26% ± 7%	Explore
liver	4 studies	33% ± 16%	Explore
pancreas	3 studies	37% ± 10%	Explore
eye	3 studies	27% ± 8%	Explore
uterus	3 studies	24% ± 12%	Explore
heart	3 studies	16% ± 0%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
bladder	100%	6758.71	21 / 21	100%	37.11	504 / 504
esophagus	100%	6129.97	1445 / 1445	100%	29.47	183 / 183
intestine	100%	7017.07	966 / 966	100%	36.58	527 / 527
liver	100%	4210.28	226 / 226	100%	22.76	406 / 406
lung	100%	6344.32	578 / 578	100%	35.01	1155 / 1155
ovary	100%	7566.45	180 / 180	100%	31.43	430 / 430
pancreas	100%	7493.13	328 / 328	100%	29.51	178 / 178
prostate	100%	7518.09	245 / 245	100%	41.64	502 / 502
skin	100%	8336.05	1809 / 1809	100%	44.54	472 / 472
stomach	100%	6784.57	359 / 359	100%	32.81	286 / 286
uterus	100%	9043.24	170 / 170	100%	38.35	459 / 459
breast	100%	8361.02	459 / 459	100%	38.51	1117 / 1118
brain	100%	6447.31	2635 / 2642	100%	38.36	705 / 705
thymus	100%	8714.90	653 / 653	100%	33.01	603 / 605
adrenal gland	100%	7602.63	258 / 258	100%	30.56	229 / 230
kidney	100%	6133.73	89 / 89	100%	26.14	897 / 901
adipose	100%	7775.82	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	28.43	80 / 80
lymph node	0%	0	0 / 0	100%	51.47	29 / 29
muscle	100%	7194.01	803 / 803	0%	0	0 / 0
spleen	100%	10015.08	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	40.65	45 / 45
ureter	0%	0	0 / 0	100%	18.67	1 / 1
blood vessel	100%	7858.40	1334 / 1335	0%	0	0 / 0
heart	99%	4433.39	850 / 861	0%	0	0 / 0
peripheral blood	96%	4998.27	888 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0031145	Biological process	anaphase-promoting complex-dependent catabolic process
GO_0070936	Biological process	protein K48-linked ubiquitination
GO_0070979	Biological process	protein K11-linked ubiquitination
GO_0051301	Biological process	cell division
GO_0051445	Biological process	regulation of meiotic cell cycle
GO_0007346	Biological process	regulation of mitotic cell cycle
GO_0045842	Biological process	positive regulation of mitotic metaphase/anaphase transition
GO_0005680	Cellular component	anaphase-promoting complex
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0005819	Cellular component	spindle
GO_0005634	Cellular component	nucleus
GO_0019903	Molecular function	protein phosphatase binding

IV. Literature review

[source]

Gene name	ANAPC5
Protein name	Anaphase-promoting complex subunit 5 ANAPC5 protein (cDNA FLJ30217 fis, clone BRACE2001709, highly similar to Anaphase-promoting complex subunit 5 (APC5)(Cyclosome subunit 5)) Anaphase promoting complex subunit 5 Anaphase-promoting complex subunit 5 (Cyclosome subunit 5) Anaphase-promoting complex subunit 5 (APC5) (Cyclosome subunit 5)
Synonyms	APC5
Description	FUNCTION: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. . FUNCTION: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. . FUNCTION: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. .
Accessions	ENST00000535482.1 F5H3S5 ENST00000539871.1 ENST00000536837.1 ENST00000544442.5 H0YFB5 F5GZ05 ENST00000539079.5 F5H0N1 ENST00000441917.6 [Q9UJX4-3] F5GY68 ENST00000261819.8 [Q9UJX4-1] F5H0F9 ENST00000541887.5 Q49A41 Q9UJX4

ANAPC5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review