ACIN1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030218Biological processerythrocyte differentiation
GO_0008380Biological processRNA splicing
GO_0006397Biological processmRNA processing
GO_0045657Biological processpositive regulation of monocyte differentiation
GO_0030263Biological processapoptotic chromosome condensation
GO_0016607Cellular componentnuclear speck
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005886Cellular componentplasma membrane
GO_0061574Cellular componentASAP complex
GO_0005634Cellular componentnucleus
GO_0019899Molecular functionenzyme binding
GO_0016887Molecular functionATP hydrolysis activity
GO_0005515Molecular functionprotein binding
GO_0003676Molecular functionnucleic acid binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameACIN1
Protein nameApoptotic chromatin condensation inducer in the nucleus (Acinus)
Apoptotic chromatin condensation inducer 1
SynonymsACINUS
KIAA0670
DescriptionFUNCTION: Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells. .

AccessionsENST00000338631.10 [Q9UKV3-2]
G3V3B0
ENST00000605057.6
A0A087WYN3
ENST00000262710.5 [Q9UKV3-1]
ENST00000557515.5
S4R3H4
ENST00000357481.6 [Q9UKV3-3]
ENST00000555352.2
A0A087X0D2
G3V3T3
ENST00000457657.5
ENST00000555566.1
Q9UKV3
E7EQT4
ENST00000473758.5
ENST00000397341.7 [Q9UKV3-3]
ENST00000555053.5 [Q9UKV3-5]