ABI1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0008285Biological processnegative regulation of cell population proliferation
GO_0072673Biological processlamellipodium morphogenesis
GO_0007169Biological processcell surface receptor protein tyrosine kinase signaling pathway
GO_0048813Biological processdendrite morphogenesis
GO_0001764Biological processneuron migration
GO_0008154Biological processactin polymerization or depolymerization
GO_0035855Biological processmegakaryocyte development
GO_0001756Biological processsomitogenesis
GO_0061098Biological processpositive regulation of protein tyrosine kinase activity
GO_0098858Cellular componentactin-based cell projection
GO_0005856Cellular componentcytoskeleton
GO_0032433Cellular componentfilopodium tip
GO_0070062Cellular componentextracellular exosome
GO_0005783Cellular componentendoplasmic reticulum
GO_0005829Cellular componentcytosol
GO_0014069Cellular componentpostsynaptic density
GO_0030426Cellular componentgrowth cone
GO_0030027Cellular componentlamellipodium
GO_0031209Cellular componentSCAR complex
GO_0005634Cellular componentnucleus
GO_0045296Molecular functioncadherin binding
GO_0030296Molecular functionprotein tyrosine kinase activator activity
GO_0035591Molecular functionsignaling adaptor activity
GO_0008092Molecular functioncytoskeletal protein binding
GO_0005515Molecular functionprotein binding
GO_0017124Molecular functionSH3 domain binding

IV. Literature review

[source]
Gene nameABI1
Protein nameAbl interactor 1 (Abl-interactor 1 variant 21)
Alternative protein ABI1
Abl interactor 1
Abl interactor 1 (Abelson interactor 1) (Abi-1) (Abl-binding protein 4) (AblBP4) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (Nap1-binding protein) (Nap1BP) (Spectrin SH3 domain-binding protein 1) (e3B1)
SynonymsSSH3BP1
DescriptionFUNCTION: May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons. .

AccessionsENST00000490841.7 [Q8IZP0-11]
ENST00000376139.6 [Q8IZP0-5]
ENST00000376170.8 [Q8IZP0-4]
ENST00000536334.5
ENST00000359188.8 [Q8IZP0-6]
L8EC66
B6VEX4
ENST00000376138.7 [Q8IZP0-3]
A0A0A0MRT6
ENST00000376160.5
ENST00000376166.5 [Q8IZP0-2]
Q8IZP0
ENST00000376137.9 [Q8IZP0-7]
ENST00000376140.4 [Q8IZP0-9]
ENST00000376142.6 [Q8IZP0-1]
ENST00000346832.10 [Q8IZP0-12]