ZC3HAV1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0009615Biological processresponse to virus
GO_0051607Biological processdefense response to virus
GO_0045071Biological processnegative regulation of viral genome replication
GO_0070212Biological processprotein poly-ADP-ribosylation
GO_0032481Biological processpositive regulation of type I interferon production
GO_0061014Biological processpositive regulation of mRNA catabolic process
GO_0045087Biological processinnate immune response
GO_0005829Cellular componentcytosol
GO_0005634Cellular componentnucleus
GO_0045296Molecular functioncadherin binding
GO_0070403Molecular functionNAD+ binding
GO_1990404Molecular functionNAD+-protein ADP-ribosyltransferase activity
GO_0003950Molecular functionNAD+ ADP-ribosyltransferase activity
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameZC3HAV1
Protein nameZinc finger CCCH-type antiviral protein 1 (ADP-ribosyltransferase diphtheria toxin-like 13) (ARTD13) (Inactive Poly [ADP-ribose] polymerase 13) (PARP13) (Zinc finger CCCH domain-containing protein 2) (Zinc finger antiviral protein) (ZAP)
Zinc finger CCCH-type containing, antiviral 1
Zinc finger CCCH-type antiviral protein 1 isoform 4
ZC3HAV1 protein
SynonymsZC3HDC2
PRO1677
DescriptionFUNCTION: Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1), moloney and murine leukemia virus (MoMLV) and xenotropic MuLV-related virus (XMRV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of RIGI signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes (ISGs). .

AccessionsA0A7P0T8C6
ENST00000460845.5
ENST00000242351.10 [Q7Z2W4-1]
A0A514C937
Q05DV5
Q7Z2W4
ENST00000471652.1 [Q7Z2W4-2]
ENST00000680309.1
ENST00000464606.5
H7C5K1
C9J6P4