ZBTB38 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	34 studies	31% ± 14%	Explore
pericyte	28 studies	33% ± 12%	Explore
smooth muscle cell	27 studies	27% ± 9%	Explore
fibroblast	24 studies	25% ± 7%	Explore
regulatory T cell	18 studies	27% ± 8%	Explore
natural killer cell	17 studies	23% ± 7%	Explore
plasma cell	16 studies	32% ± 10%	Explore
CD8-positive, alpha-beta T cell	15 studies	25% ± 8%	Explore
endothelial cell of lymphatic vessel	12 studies	24% ± 5%	Explore
oligodendrocyte	12 studies	32% ± 12%	Explore
CD8-positive, alpha-beta memory T cell	11 studies	24% ± 6%	Explore
glutamatergic neuron	11 studies	42% ± 26%	Explore
mature NK T cell	11 studies	24% ± 6%	Explore
capillary endothelial cell	11 studies	26% ± 7%	Explore
gamma-delta T cell	11 studies	26% ± 7%	Explore
endothelial cell of artery	10 studies	25% ± 4%	Explore
CD16-positive, CD56-dim natural killer cell, human	9 studies	23% ± 4%	Explore
CD4-positive, alpha-beta T cell	9 studies	19% ± 3%	Explore
epithelial cell	9 studies	39% ± 20%	Explore
astrocyte	9 studies	30% ± 11%	Explore
effector memory CD8-positive, alpha-beta T cell	9 studies	27% ± 8%	Explore
type I pneumocyte	8 studies	21% ± 3%	Explore
basal cell	8 studies	25% ± 9%	Explore
CD16-negative, CD56-bright natural killer cell, human	8 studies	19% ± 3%	Explore
endothelial cell of vascular tree	8 studies	26% ± 12%	Explore
GABAergic neuron	8 studies	44% ± 25%	Explore
macrophage	8 studies	22% ± 5%	Explore
T cell	7 studies	21% ± 5%	Explore
IgA plasma cell	7 studies	24% ± 8%	Explore
mucosal invariant T cell	7 studies	23% ± 4%	Explore
secretory cell	6 studies	23% ± 4%	Explore
retina horizontal cell	6 studies	31% ± 11%	Explore
vein endothelial cell	6 studies	22% ± 9%	Explore
abnormal cell	6 studies	33% ± 21%	Explore
CD4-positive, alpha-beta memory T cell	5 studies	19% ± 4%	Explore
respiratory goblet cell	5 studies	22% ± 7%	Explore
effector CD8-positive, alpha-beta T cell	5 studies	23% ± 7%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	5 studies	23% ± 3%	Explore
neuron	5 studies	32% ± 13%	Explore
microglial cell	5 studies	27% ± 6%	Explore
myofibroblast cell	5 studies	24% ± 6%	Explore
mast cell	5 studies	23% ± 6%	Explore
amacrine cell	5 studies	37% ± 10%	Explore
retinal cone cell	5 studies	35% ± 14%	Explore
retinal rod cell	5 studies	19% ± 3%	Explore
adipocyte	5 studies	22% ± 3%	Explore
cardiac muscle cell	5 studies	33% ± 8%	Explore
lymphocyte	5 studies	25% ± 7%	Explore
T follicular helper cell	5 studies	21% ± 3%	Explore
plasmablast	5 studies	34% ± 14%	Explore
type II pneumocyte	5 studies	19% ± 2%	Explore
oligodendrocyte precursor cell	5 studies	34% ± 12%	Explore
interneuron	5 studies	46% ± 22%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	27% ± 7%	Explore
memory B cell	5 studies	19% ± 3%	Explore
leukocyte	4 studies	20% ± 5%	Explore
IgG plasma cell	4 studies	22% ± 4%	Explore
retinal ganglion cell	4 studies	32% ± 9%	Explore
ciliated cell	4 studies	29% ± 13%	Explore
club cell	4 studies	22% ± 5%	Explore
retinal pigment epithelial cell	4 studies	26% ± 6%	Explore
Mueller cell	4 studies	20% ± 1%	Explore
muscle cell	4 studies	31% ± 3%	Explore
transit amplifying cell	4 studies	26% ± 11%	Explore
B cell	3 studies	19% ± 3%	Explore
squamous epithelial cell	3 studies	38% ± 23%	Explore
exhausted T cell	3 studies	35% ± 6%	Explore
glomerular endothelial cell	3 studies	27% ± 1%	Explore
retinal bipolar neuron	3 studies	26% ± 5%	Explore
GABAergic interneuron	3 studies	25% ± 1%	Explore
myeloid cell	3 studies	23% ± 5%	Explore
glycinergic amacrine cell	3 studies	22% ± 3%	Explore
rod bipolar cell	3 studies	27% ± 6%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	19% ± 3%	Explore
intestinal crypt stem cell	3 studies	32% ± 7%	Explore
brush cell	3 studies	20% ± 4%	Explore
granule cell	3 studies	28% ± 2%	Explore
connective tissue cell	3 studies	26% ± 6%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	15 studies	35% ± 21%	Explore
lung	8 studies	22% ± 3%	Explore
eye	6 studies	25% ± 5%	Explore
peripheral blood	5 studies	19% ± 4%	Explore
heart	4 studies	24% ± 3%	Explore
intestine	4 studies	19% ± 3%	Explore
adipose	4 studies	25% ± 7%	Explore
uterus	3 studies	27% ± 8%	Explore
kidney	3 studies	26% ± 3%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	100%	5980.36	578 / 578	100%	24.70	1152 / 1155
intestine	100%	6562.40	966 / 966	100%	24.75	525 / 527
ovary	100%	4062.19	180 / 180	98%	14.15	422 / 430
breast	100%	4917.59	459 / 459	98%	21.08	1094 / 1118
stomach	99%	3652.00	355 / 359	99%	26.37	282 / 286
kidney	100%	3520.94	89 / 89	97%	26.47	877 / 901
brain	98%	3445.59	2578 / 2642	99%	16.75	700 / 705
esophagus	97%	4746.15	1398 / 1445	100%	26.78	183 / 183
prostate	100%	4392.87	244 / 245	96%	16.92	482 / 502
pancreas	96%	2254.56	316 / 328	98%	18.39	175 / 178
adrenal gland	100%	7362.22	258 / 258	94%	14.81	216 / 230
bladder	100%	6224.43	21 / 21	94%	17.02	472 / 504
thymus	100%	4514.92	652 / 653	93%	19.80	564 / 605
skin	99%	7147.30	1790 / 1809	92%	22.48	436 / 472
uterus	100%	7824.13	170 / 170	88%	14.90	404 / 459
liver	90%	1938.01	204 / 226	77%	10.02	314 / 406
adipose	100%	4987.87	1204 / 1204	0%	0	0 / 0
blood vessel	100%	8727.93	1335 / 1335	0%	0	0 / 0
muscle	100%	9836.65	803 / 803	0%	0	0 / 0
spleen	100%	3145.20	241 / 241	0%	0	0 / 0
heart	95%	3943.30	822 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	93%	17.47	27 / 29
tonsil	0%	0	0 / 0	84%	13.75	38 / 45
eye	0%	0	0 / 0	54%	5.19	43 / 80
peripheral blood	26%	2693.76	238 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0006974	Biological process	DNA damage response
GO_0006275	Biological process	regulation of DNA replication
GO_0045892	Biological process	negative regulation of DNA-templated transcription
GO_0006355	Biological process	regulation of DNA-templated transcription
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0072562	Cellular component	blood microparticle
GO_0005694	Cellular component	chromosome
GO_0005654	Cellular component	nucleoplasm
GO_0005634	Cellular component	nucleus
GO_0042803	Molecular function	protein homodimerization activity
GO_0000978	Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0008327	Molecular function	methyl-CpG binding
GO_0000981	Molecular function	DNA-binding transcription factor activity, RNA polymerase II-specific
GO_0003700	Molecular function	DNA-binding transcription factor activity
GO_0005515	Molecular function	protein binding
GO_0046872	Molecular function	metal ion binding

IV. Literature review

[source]

Gene name	ZBTB38
Protein name	Zinc finger and BTB domain-containing protein 38 ZBTB38 protein Zinc finger and BTB domain containing 38
Synonyms
Description	FUNCTION: Transcriptional regulator with bimodal DNA-binding specificity. Binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to E-box elements (5'-CACGTG-3'). Can also bind specifically to a single methyl-CpG pair. Represses transcription in a methyl-CpG-dependent manner . Plays an important role in regulating DNA replication and common fragile sites (CFS) stability in a RBBP6- and MCM10-dependent manner; represses expression of MCM10 which plays an important role in DNA-replication . Acts as a transcriptional activator. May be involved in the differentiation and/or survival of late postmitotic neurons (By similarity). .
Accessions	Q32Q70 D6RAC4 ENST00000321464.7 Q8NAP3 D6RE69 D6RHD1 ENST00000509813.1 ENST00000509842.5 D6R9U6 ENST00000510726.1 ENST00000513258.5 ENST00000509883.5 D6RBC4 ENST00000503809.5 ENST00000510338.5 D6RJE1 D6R9J6 D6RGK1 ENST00000514251.5 ENST00000507722.5 ENST00000513570.1 A0A1B0GV48 ENST00000441582.2 ENST00000636289.1 D6R9I1 ENST00000637056.1 ENST00000504673.5 D6RC86

ZBTB38 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review