VPS13C | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	32 studies	32% ± 13%	Explore
macrophage	32 studies	37% ± 19%	Explore
endothelial cell	31 studies	38% ± 15%	Explore
natural killer cell	27 studies	29% ± 11%	Explore
classical monocyte	21 studies	27% ± 10%	Explore
CD8-positive, alpha-beta T cell	21 studies	26% ± 9%	Explore
T cell	19 studies	28% ± 12%	Explore
non-classical monocyte	19 studies	28% ± 10%	Explore
regulatory T cell	19 studies	27% ± 7%	Explore
fibroblast	18 studies	29% ± 12%	Explore
pericyte	18 studies	29% ± 14%	Explore
memory B cell	18 studies	27% ± 6%	Explore
ciliated cell	18 studies	38% ± 14%	Explore
astrocyte	18 studies	45% ± 22%	Explore
CD4-positive, alpha-beta T cell	18 studies	24% ± 6%	Explore
mast cell	17 studies	31% ± 11%	Explore
plasmacytoid dendritic cell	17 studies	35% ± 12%	Explore
naive B cell	17 studies	31% ± 7%	Explore
conventional dendritic cell	16 studies	26% ± 11%	Explore
oligodendrocyte	16 studies	48% ± 22%	Explore
monocyte	15 studies	31% ± 13%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	29% ± 7%	Explore
oligodendrocyte precursor cell	15 studies	45% ± 22%	Explore
microglial cell	15 studies	52% ± 24%	Explore
gamma-delta T cell	15 studies	27% ± 7%	Explore
CD16-negative, CD56-bright natural killer cell, human	14 studies	30% ± 8%	Explore
mucosal invariant T cell	14 studies	29% ± 7%	Explore
endothelial cell of lymphatic vessel	13 studies	39% ± 15%	Explore
smooth muscle cell	13 studies	29% ± 9%	Explore
mature NK T cell	13 studies	26% ± 8%	Explore
dendritic cell	12 studies	42% ± 17%	Explore
basal cell	12 studies	32% ± 18%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	12 studies	24% ± 6%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	12 studies	21% ± 4%	Explore
glutamatergic neuron	12 studies	49% ± 28%	Explore
type I pneumocyte	11 studies	31% ± 14%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	21% ± 4%	Explore
CD8-positive, alpha-beta memory T cell	11 studies	26% ± 6%	Explore
GABAergic neuron	11 studies	50% ± 28%	Explore
effector memory CD8-positive, alpha-beta T cell	11 studies	29% ± 7%	Explore
epithelial cell	10 studies	37% ± 21%	Explore
myeloid cell	9 studies	42% ± 11%	Explore
respiratory goblet cell	8 studies	37% ± 16%	Explore
capillary endothelial cell	8 studies	23% ± 6%	Explore
neuron	8 studies	39% ± 20%	Explore
endothelial cell of artery	8 studies	20% ± 4%	Explore
type II pneumocyte	7 studies	28% ± 7%	Explore
club cell	7 studies	37% ± 13%	Explore
leukocyte	7 studies	42% ± 21%	Explore
amacrine cell	7 studies	35% ± 20%	Explore
interneuron	7 studies	51% ± 31%	Explore
retinal ganglion cell	7 studies	40% ± 24%	Explore
retinal cone cell	7 studies	43% ± 19%	Explore
adipocyte	7 studies	31% ± 9%	Explore
vein endothelial cell	7 studies	28% ± 19%	Explore
alveolar macrophage	6 studies	39% ± 16%	Explore
mononuclear phagocyte	6 studies	29% ± 10%	Explore
retina horizontal cell	6 studies	44% ± 21%	Explore
secretory cell	5 studies	32% ± 13%	Explore
plasmablast	5 studies	28% ± 12%	Explore
retinal bipolar neuron	5 studies	25% ± 6%	Explore
plasma cell	5 studies	33% ± 10%	Explore
lymphocyte	5 studies	46% ± 17%	Explore
Mueller cell	5 studies	32% ± 19%	Explore
retinal rod cell	5 studies	33% ± 14%	Explore
endothelial cell of vascular tree	5 studies	35% ± 20%	Explore
myofibroblast cell	5 studies	23% ± 10%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	26% ± 7%	Explore
innate lymphoid cell	5 studies	23% ± 3%	Explore
goblet cell	5 studies	33% ± 23%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	27% ± 7%	Explore
hematopoietic precursor cell	4 studies	27% ± 9%	Explore
effector CD8-positive, alpha-beta T cell	4 studies	20% ± 4%	Explore
differentiation-committed oligodendrocyte precursor	4 studies	45% ± 11%	Explore
glial cell	4 studies	34% ± 11%	Explore
granule cell	4 studies	40% ± 3%	Explore
precursor B cell	4 studies	27% ± 3%	Explore
immature B cell	4 studies	28% ± 9%	Explore
retinal pigment epithelial cell	4 studies	39% ± 22%	Explore
cardiac muscle cell	4 studies	26% ± 4%	Explore
T follicular helper cell	4 studies	24% ± 5%	Explore
abnormal cell	4 studies	29% ± 10%	Explore
connective tissue cell	4 studies	24% ± 4%	Explore
brush cell	4 studies	23% ± 7%	Explore
ionocyte	3 studies	36% ± 10%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	24% ± 4%	Explore
exhausted T cell	3 studies	28% ± 9%	Explore
glomerular endothelial cell	3 studies	26% ± 2%	Explore
GABAergic interneuron	3 studies	44% ± 19%	Explore
progenitor cell	3 studies	29% ± 8%	Explore
pro-B cell	3 studies	23% ± 3%	Explore
mesothelial cell	3 studies	25% ± 10%	Explore
OFF-bipolar cell	3 studies	35% ± 15%	Explore
ON-bipolar cell	3 studies	42% ± 16%	Explore
glycinergic amacrine cell	3 studies	39% ± 18%	Explore
rod bipolar cell	3 studies	48% ± 21%	Explore
intermediate monocyte	3 studies	39% ± 23%	Explore
CD4-positive helper T cell	3 studies	26% ± 9%	Explore
hepatocyte	3 studies	39% ± 22%	Explore
muscle cell	3 studies	37% ± 24%	Explore
neural progenitor cell	3 studies	28% ± 6%	Explore
ependymal cell	3 studies	42% ± 27%	Explore
enteroendocrine cell	3 studies	23% ± 3%	Explore
group 3 innate lymphoid cell	3 studies	31% ± 10%	Explore
Schwann cell	3 studies	41% ± 27%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	24% ± 1%	Explore
central memory CD8-positive, alpha-beta T cell	3 studies	23% ± 2%	Explore
double negative thymocyte	3 studies	30% ± 7%	Explore
renal principal cell	3 studies	27% ± 7%	Explore
mural cell	3 studies	41% ± 22%	Explore
mucus secreting cell	3 studies	36% ± 8%	Explore
erythrocyte	3 studies	16% ± 1%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	20 studies	44% ± 24%	Explore
peripheral blood	16 studies	27% ± 9%	Explore
lung	10 studies	35% ± 9%	Explore
eye	7 studies	38% ± 20%	Explore
kidney	5 studies	25% ± 4%	Explore
bone marrow	4 studies	21% ± 4%	Explore
heart	4 studies	28% ± 7%	Explore
lymph node	4 studies	18% ± 3%	Explore
liver	4 studies	26% ± 11%	Explore
adipose	4 studies	33% ± 8%	Explore
uterus	3 studies	30% ± 11%	Explore
breast	3 studies	17% ± 1%	Explore
intestine	3 studies	17% ± 1%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	99%	4226.16	2611 / 2642	99%	15.26	701 / 705
thymus	100%	5356.16	653 / 653	98%	16.51	594 / 605
lung	100%	6670.39	577 / 578	98%	14.32	1134 / 1155
stomach	100%	4657.02	359 / 359	98%	13.92	279 / 286
pancreas	99%	3149.84	324 / 328	98%	14.25	175 / 178
kidney	100%	3330.22	89 / 89	97%	14.54	871 / 901
prostate	100%	4551.29	245 / 245	96%	13.29	482 / 502
intestine	100%	5974.99	966 / 966	96%	11.39	505 / 527
breast	100%	5960.83	459 / 459	94%	15.23	1053 / 1118
esophagus	94%	4072.63	1359 / 1445	99%	16.46	182 / 183
adrenal gland	100%	5243.33	258 / 258	93%	14.54	215 / 230
bladder	100%	5498.14	21 / 21	93%	10.23	469 / 504
skin	100%	4445.88	1808 / 1809	90%	11.74	423 / 472
uterus	100%	7516.76	170 / 170	88%	8.47	402 / 459
ovary	100%	8228.34	180 / 180	85%	5.22	366 / 430
liver	92%	1568.52	209 / 226	67%	4.72	270 / 406
adipose	100%	6259.33	1204 / 1204	0%	0	0 / 0
muscle	100%	4255.35	803 / 803	0%	0	0 / 0
spleen	100%	8051.58	241 / 241	0%	0	0 / 0
blood vessel	100%	5821.40	1334 / 1335	0%	0	0 / 0
heart	97%	3327.08	838 / 861	0%	0	0 / 0
tonsil	0%	0	0 / 0	87%	7.34	39 / 45
lymph node	0%	0	0 / 0	83%	12.33	24 / 29
peripheral blood	68%	3439.81	629 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	46%	3.86	37 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0045053	Biological process	protein retention in Golgi apparatus
GO_0006623	Biological process	protein targeting to vacuole
GO_0032868	Biological process	response to insulin
GO_0007005	Biological process	mitochondrion organization
GO_0006869	Biological process	lipid transport
GO_1905090	Biological process	negative regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization
GO_0006895	Biological process	Golgi to endosome transport
GO_0005741	Cellular component	mitochondrial outer membrane
GO_0005764	Cellular component	lysosome
GO_0005737	Cellular component	cytoplasm
GO_0070062	Cellular component	extracellular exosome
GO_0031902	Cellular component	late endosome membrane
GO_0005829	Cellular component	cytosol
GO_0005811	Cellular component	lipid droplet
GO_0032127	Cellular component	dense core granule membrane
GO_0005765	Cellular component	lysosomal membrane
GO_0005770	Cellular component	late endosome
GO_0005789	Cellular component	endoplasmic reticulum membrane

IV. Literature review

[source]

Gene name	VPS13C
Protein name	Intermembrane lipid transfer protein VPS13C (Vacuolar protein sorting-associated protein 13C) Vacuolar protein sorting 13 homolog C
Synonyms	KIAA1421
Description	FUNCTION: Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Necessary for proper mitochondrial function and maintenance of mitochondrial transmembrane potential . Involved in the regulation of PINK1/PRKN-mediated mitophagy in response to mitochondrial depolarization . .
Accessions	Q709C8 A0A3B3IT88 ENST00000249837.7 [Q709C8-3] ENST00000395898.3 [Q709C8-4] A0A3B3IU50 ENST00000650094.1 ENST00000649766.1 ENST00000644861.2 [Q709C8-1] ENST00000645819.1 [Q709C8-2]

VPS13C report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review