USP16 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	30 studies	23% ± 9%	Explore
natural killer cell	29 studies	23% ± 7%	Explore
CD8-positive, alpha-beta T cell	24 studies	22% ± 6%	Explore
CD4-positive, alpha-beta T cell	22 studies	22% ± 8%	Explore
fibroblast	18 studies	23% ± 8%	Explore
smooth muscle cell	18 studies	21% ± 5%	Explore
regulatory T cell	18 studies	23% ± 5%	Explore
T cell	17 studies	22% ± 5%	Explore
endothelial cell	17 studies	26% ± 8%	Explore
pericyte	17 studies	20% ± 4%	Explore
memory B cell	17 studies	21% ± 6%	Explore
naive B cell	15 studies	23% ± 7%	Explore
gamma-delta T cell	15 studies	24% ± 9%	Explore
ciliated cell	14 studies	29% ± 13%	Explore
CD16-positive, CD56-dim natural killer cell, human	12 studies	25% ± 9%	Explore
classical monocyte	12 studies	24% ± 10%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	12 studies	22% ± 8%	Explore
CD16-negative, CD56-bright natural killer cell, human	12 studies	22% ± 5%	Explore
mature NK T cell	12 studies	22% ± 5%	Explore
mucosal invariant T cell	12 studies	21% ± 4%	Explore
mast cell	10 studies	21% ± 5%	Explore
CD8-positive, alpha-beta memory T cell	10 studies	25% ± 8%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	10 studies	23% ± 7%	Explore
CD4-positive, alpha-beta memory T cell	9 studies	22% ± 5%	Explore
conventional dendritic cell	9 studies	26% ± 16%	Explore
effector memory CD8-positive, alpha-beta T cell	9 studies	25% ± 11%	Explore
plasmacytoid dendritic cell	9 studies	24% ± 7%	Explore
type II pneumocyte	8 studies	23% ± 13%	Explore
plasma cell	8 studies	29% ± 11%	Explore
non-classical monocyte	8 studies	28% ± 12%	Explore
basal cell	8 studies	28% ± 9%	Explore
macrophage	8 studies	21% ± 5%	Explore
monocyte	7 studies	19% ± 4%	Explore
retinal rod cell	7 studies	28% ± 9%	Explore
connective tissue cell	7 studies	21% ± 5%	Explore
epithelial cell	7 studies	43% ± 19%	Explore
T follicular helper cell	7 studies	22% ± 4%	Explore
endothelial cell of lymphatic vessel	6 studies	21% ± 4%	Explore
plasmablast	6 studies	40% ± 20%	Explore
secretory cell	6 studies	21% ± 7%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	19% ± 4%	Explore
myofibroblast cell	6 studies	20% ± 3%	Explore
astrocyte	6 studies	27% ± 9%	Explore
oligodendrocyte	6 studies	27% ± 6%	Explore
type I pneumocyte	5 studies	25% ± 8%	Explore
precursor B cell	5 studies	29% ± 6%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	27% ± 13%	Explore
innate lymphoid cell	5 studies	20% ± 4%	Explore
goblet cell	5 studies	28% ± 12%	Explore
endothelial cell of vascular tree	5 studies	21% ± 5%	Explore
pancreatic A cell	4 studies	37% ± 5%	Explore
leukocyte	4 studies	24% ± 5%	Explore
exhausted T cell	4 studies	27% ± 12%	Explore
hematopoietic precursor cell	4 studies	25% ± 14%	Explore
retinal bipolar neuron	4 studies	42% ± 13%	Explore
dendritic cell	4 studies	37% ± 21%	Explore
lymphocyte	4 studies	27% ± 9%	Explore
amacrine cell	4 studies	31% ± 13%	Explore
retina horizontal cell	4 studies	26% ± 8%	Explore
retinal cone cell	4 studies	35% ± 17%	Explore
Mueller cell	4 studies	27% ± 6%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	21% ± 3%	Explore
neuron	4 studies	27% ± 12%	Explore
oligodendrocyte precursor cell	4 studies	27% ± 5%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	19% ± 1%	Explore
ionocyte	3 studies	24% ± 2%	Explore
type B pancreatic cell	3 studies	42% ± 4%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	23% ± 4%	Explore
mononuclear phagocyte	3 studies	25% ± 7%	Explore
capillary endothelial cell	3 studies	19% ± 1%	Explore
myeloid cell	3 studies	34% ± 12%	Explore
club cell	3 studies	25% ± 9%	Explore
immature B cell	3 studies	25% ± 5%	Explore
microglial cell	3 studies	25% ± 5%	Explore
adipocyte	3 studies	21% ± 4%	Explore
rod bipolar cell	3 studies	33% ± 4%	Explore
CD4-positive helper T cell	3 studies	23% ± 4%	Explore
abnormal cell	3 studies	25% ± 5%	Explore
granulocyte	3 studies	19% ± 1%	Explore
T-helper 17 cell	3 studies	22% ± 3%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	18% ± 2%	Explore
central memory CD8-positive, alpha-beta T cell	3 studies	19% ± 1%	Explore
double negative thymocyte	3 studies	31% ± 11%	Explore
glutamatergic neuron	3 studies	35% ± 8%	Explore
interneuron	3 studies	36% ± 12%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	16 studies	24% ± 11%	Explore
lung	13 studies	22% ± 7%	Explore
eye	8 studies	29% ± 9%	Explore
brain	5 studies	31% ± 6%	Explore
intestine	5 studies	22% ± 9%	Explore
pancreas	4 studies	35% ± 10%	Explore
liver	4 studies	26% ± 10%	Explore
uterus	3 studies	28% ± 12%	Explore
breast	3 studies	17% ± 2%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	2702.38	1445 / 1445	100%	24.11	183 / 183
breast	100%	2866.88	459 / 459	100%	35.31	1117 / 1118
brain	100%	2488.14	2639 / 2642	100%	31.12	705 / 705
lung	100%	2491.95	577 / 578	100%	25.28	1155 / 1155
prostate	100%	2855.00	245 / 245	100%	30.99	501 / 502
ovary	100%	2655.25	180 / 180	100%	17.37	428 / 430
thymus	100%	3169.00	653 / 653	99%	27.54	601 / 605
uterus	100%	2980.15	170 / 170	99%	25.73	455 / 459
pancreas	100%	1894.28	328 / 328	99%	21.06	176 / 178
bladder	100%	2906.76	21 / 21	99%	24.01	498 / 504
intestine	100%	3056.50	966 / 966	98%	23.10	518 / 527
stomach	100%	2332.32	359 / 359	98%	21.97	281 / 286
adrenal gland	100%	2678.53	258 / 258	97%	22.00	223 / 230
kidney	100%	1973.27	89 / 89	96%	19.59	869 / 901
liver	100%	1588.72	226 / 226	96%	14.93	388 / 406
skin	100%	2593.69	1808 / 1809	93%	26.03	441 / 472
blood vessel	100%	3376.69	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	25.14	29 / 29
muscle	100%	2678.60	803 / 803	0%	0	0 / 0
spleen	100%	2844.77	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	25.94	45 / 45
ureter	0%	0	0 / 0	100%	9.14	1 / 1
adipose	100%	2885.33	1203 / 1204	0%	0	0 / 0
heart	97%	1904.75	834 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	79%	12.40	63 / 80
peripheral blood	67%	1394.95	623 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0045901	Biological process	positive regulation of translational elongation
GO_0140014	Biological process	mitotic nuclear division
GO_0006357	Biological process	regulation of transcription by RNA polymerase II
GO_0006974	Biological process	DNA damage response
GO_0051301	Biological process	cell division
GO_0035520	Biological process	monoubiquitinated protein deubiquitination
GO_0051289	Biological process	protein homotetramerization
GO_0006338	Biological process	chromatin remodeling
GO_0045893	Biological process	positive regulation of DNA-templated transcription
GO_0006508	Biological process	proteolysis
GO_0090070	Biological process	positive regulation of ribosome biogenesis
GO_0051726	Biological process	regulation of cell cycle
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0005654	Cellular component	nucleoplasm
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0140950	Molecular function	histone H2A deubiquitinase activity
GO_0004843	Molecular function	cysteine-type deubiquitinase activity
GO_0042393	Molecular function	histone binding
GO_0043024	Molecular function	ribosomal small subunit binding
GO_0008270	Molecular function	zinc ion binding
GO_0003713	Molecular function	transcription coactivator activity
GO_0004197	Molecular function	cysteine-type endopeptidase activity
GO_0043130	Molecular function	ubiquitin binding

IV. Literature review

[source]

Gene name	USP16
Protein name	Ubiquitin carboxyl-terminal hydrolase 16 (EC 3.4.19.12) (Deubiquitinating enzyme 16) (Ubiquitin thioesterase 16) (Ubiquitin-processing protease UBP-M) (Ubiquitin-specific-processing protease 16) Ubiquitin specific peptidase 16
Synonyms	MSTP039
Description	FUNCTION: Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator . Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis . In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination . Prefers nucleosomal substrates . Does not deubiquitinate histone H2B . Also deubiquitinates non-histone proteins, such as ribosomal protein RPS27A: deubiquitination of monoubiquitinated RPS27A promotes maturation of the 40S ribosomal subunit . .
Accessions	ENST00000399976.7 [Q9Y5T5-1] ENST00000707870.1 [Q9Y5T5-1] Q9Y5T5 H9KVB6 ENST00000707868.1 [Q9Y5T5-2] ENST00000399975.7 [Q9Y5T5-2] ENST00000707869.1 [Q9Y5T5-1] ENST00000399973.1 ENST00000334352.8 [Q9Y5T5-1]

USP16 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review