UBE2L6 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	29 studies	32% ± 12%	Explore
CD4-positive, alpha-beta T cell	23 studies	28% ± 10%	Explore
CD8-positive, alpha-beta T cell	23 studies	34% ± 12%	Explore
non-classical monocyte	21 studies	40% ± 16%	Explore
macrophage	20 studies	31% ± 11%	Explore
conventional dendritic cell	17 studies	33% ± 14%	Explore
T cell	17 studies	30% ± 10%	Explore
B cell	17 studies	27% ± 11%	Explore
endothelial cell	17 studies	28% ± 11%	Explore
classical monocyte	16 studies	32% ± 13%	Explore
regulatory T cell	16 studies	36% ± 14%	Explore
mature NK T cell	14 studies	34% ± 11%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	35% ± 11%	Explore
memory B cell	13 studies	25% ± 9%	Explore
naive B cell	13 studies	27% ± 9%	Explore
plasmacytoid dendritic cell	12 studies	36% ± 14%	Explore
gamma-delta T cell	12 studies	34% ± 12%	Explore
CD16-negative, CD56-bright natural killer cell, human	11 studies	39% ± 10%	Explore
monocyte	11 studies	33% ± 9%	Explore
dendritic cell	10 studies	31% ± 19%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	10 studies	23% ± 6%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	10 studies	31% ± 12%	Explore
capillary endothelial cell	9 studies	23% ± 6%	Explore
mucosal invariant T cell	9 studies	30% ± 6%	Explore
fibroblast	9 studies	29% ± 13%	Explore
CD4-positive, alpha-beta memory T cell	8 studies	32% ± 13%	Explore
CD8-positive, alpha-beta memory T cell	8 studies	37% ± 17%	Explore
myeloid cell	8 studies	31% ± 11%	Explore
plasma cell	7 studies	35% ± 5%	Explore
effector memory CD8-positive, alpha-beta T cell	7 studies	32% ± 11%	Explore
endothelial cell of artery	7 studies	21% ± 6%	Explore
endothelial cell of lymphatic vessel	7 studies	30% ± 10%	Explore
plasmablast	6 studies	39% ± 20%	Explore
T follicular helper cell	6 studies	24% ± 7%	Explore
exhausted T cell	5 studies	45% ± 9%	Explore
endothelial cell of vascular tree	5 studies	25% ± 6%	Explore
epithelial cell	5 studies	34% ± 10%	Explore
basal cell	5 studies	30% ± 10%	Explore
ciliated cell	5 studies	31% ± 5%	Explore
effector CD8-positive, alpha-beta T cell	5 studies	43% ± 11%	Explore
connective tissue cell	5 studies	22% ± 5%	Explore
leukocyte	4 studies	21% ± 7%	Explore
hematopoietic stem cell	4 studies	40% ± 18%	Explore
pro-B cell	4 studies	33% ± 7%	Explore
pericyte	4 studies	21% ± 5%	Explore
immature B cell	4 studies	41% ± 14%	Explore
precursor B cell	4 studies	31% ± 9%	Explore
alveolar macrophage	4 studies	31% ± 1%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	54% ± 3%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	37% ± 7%	Explore
innate lymphoid cell	4 studies	29% ± 10%	Explore
group 3 innate lymphoid cell	4 studies	37% ± 12%	Explore
mast cell	4 studies	26% ± 10%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	29% ± 9%	Explore
hematopoietic precursor cell	3 studies	54% ± 9%	Explore
secretory cell	3 studies	25% ± 11%	Explore
pancreatic A cell	3 studies	18% ± 1%	Explore
mononuclear phagocyte	3 studies	34% ± 12%	Explore
glomerular endothelial cell	3 studies	24% ± 6%	Explore
smooth muscle cell	3 studies	18% ± 1%	Explore
erythroblast	3 studies	29% ± 10%	Explore
intraepithelial lymphocyte	3 studies	30% ± 10%	Explore
abnormal cell	3 studies	42% ± 23%	Explore
intermediate monocyte	3 studies	50% ± 20%	Explore
goblet cell	3 studies	16% ± 0%	Explore
erythrocyte	3 studies	32% ± 12%	Explore
T-helper 1 cell	3 studies	31% ± 7%	Explore
T-helper 17 cell	3 studies	30% ± 8%	Explore
double negative thymocyte	3 studies	45% ± 17%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	14 studies	32% ± 8%	Explore
lung	9 studies	25% ± 8%	Explore
lymph node	4 studies	26% ± 11%	Explore
kidney	3 studies	33% ± 13%	Explore
liver	3 studies	28% ± 12%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	2691.08	2639 / 2642	100%	198.62	704 / 705
ovary	100%	2798.35	180 / 180	99%	231.74	427 / 430
breast	100%	3194.62	459 / 459	98%	214.76	1097 / 1118
uterus	100%	3011.95	170 / 170	98%	199.47	449 / 459
lung	100%	4710.57	578 / 578	98%	165.94	1127 / 1155
kidney	100%	2917.47	89 / 89	97%	149.48	874 / 901
thymus	100%	2450.41	652 / 653	97%	115.76	587 / 605
esophagus	100%	2179.80	1443 / 1445	96%	129.42	175 / 183
stomach	99%	1992.29	357 / 359	95%	127.44	273 / 286
intestine	100%	2599.69	966 / 966	95%	135.78	499 / 527
prostate	100%	2949.91	245 / 245	94%	116.05	474 / 502
bladder	100%	2474.19	21 / 21	94%	167.11	475 / 504
skin	100%	2471.59	1807 / 1809	93%	173.30	440 / 472
liver	100%	3720.58	226 / 226	93%	106.39	376 / 406
adrenal gland	100%	3556.71	258 / 258	91%	82.67	209 / 230
pancreas	77%	756.98	251 / 328	97%	141.12	173 / 178
adipose	100%	3554.85	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	327.01	29 / 29
spleen	100%	5823.16	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	32.38	1 / 1
blood vessel	100%	2352.59	1333 / 1335	0%	0	0 / 0
peripheral blood	100%	5767.99	926 / 929	0%	0	0 / 0
tonsil	0%	0	0 / 0	98%	228.11	44 / 45
heart	95%	1144.52	817 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	50%	55.35	40 / 80
muscle	41%	316.13	329 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006511	Biological process	ubiquitin-dependent protein catabolic process
GO_0032020	Biological process	ISG15-protein conjugation
GO_0000209	Biological process	protein polyubiquitination
GO_0036211	Biological process	protein modification process
GO_0045087	Biological process	innate immune response
GO_0000151	Cellular component	ubiquitin ligase complex
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0004842	Molecular function	ubiquitin-protein transferase activity
GO_0061631	Molecular function	ubiquitin conjugating enzyme activity
GO_0031625	Molecular function	ubiquitin protein ligase binding
GO_0005515	Molecular function	protein binding
GO_0042296	Molecular function	ISG15 transferase activity
GO_0043130	Molecular function	ubiquitin binding

IV. Literature review

[source]

Gene name	UBE2L6
Protein name	Ubiquitin/ISG15-conjugating enzyme E2 L6 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme L6) (Retinoic acid-induced gene B protein) (RIG-B) (UbcH8) (Ubiquitin carrier protein L6) (Ubiquitin-protein ligase L6) E2 ubiquitin-conjugating enzyme (EC 2.3.2.23) Ubiquitin conjugating enzyme E2 L6
Synonyms	UBCH8
Description	FUNCTION: Catalyzes the covalent attachment of ubiquitin or ISG15 to other proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Promotes ubiquitination and subsequent proteasomal degradation of FLT3. .
Accessions	E9PKW8 ENST00000527022.1 ENST00000287156.9 [O14933-1] E9PQT7 ENST00000526659.1 ENST00000340573.8 [O14933-2] O14933

UBE2L6 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review