UBE2A | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	20 studies	22% ± 6%	Explore
natural killer cell	20 studies	22% ± 6%	Explore
macrophage	20 studies	22% ± 8%	Explore
conventional dendritic cell	19 studies	26% ± 13%	Explore
non-classical monocyte	16 studies	28% ± 13%	Explore
endothelial cell	15 studies	25% ± 8%	Explore
fibroblast	15 studies	23% ± 7%	Explore
T cell	14 studies	23% ± 5%	Explore
classical monocyte	14 studies	22% ± 9%	Explore
monocyte	13 studies	20% ± 6%	Explore
smooth muscle cell	13 studies	21% ± 5%	Explore
CD8-positive, alpha-beta T cell	13 studies	27% ± 7%	Explore
regulatory T cell	12 studies	20% ± 4%	Explore
CD4-positive, alpha-beta T cell	11 studies	24% ± 7%	Explore
plasmacytoid dendritic cell	11 studies	25% ± 10%	Explore
pericyte	11 studies	25% ± 6%	Explore
dendritic cell	10 studies	29% ± 18%	Explore
mature NK T cell	9 studies	19% ± 3%	Explore
memory B cell	9 studies	22% ± 5%	Explore
epithelial cell	9 studies	34% ± 20%	Explore
gamma-delta T cell	9 studies	25% ± 12%	Explore
naive B cell	8 studies	23% ± 7%	Explore
basal cell	8 studies	26% ± 13%	Explore
CD16-positive, CD56-dim natural killer cell, human	7 studies	21% ± 4%	Explore
myofibroblast cell	7 studies	22% ± 5%	Explore
connective tissue cell	7 studies	21% ± 5%	Explore
myeloid cell	7 studies	26% ± 10%	Explore
ciliated cell	7 studies	34% ± 11%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	27% ± 6%	Explore
CD16-negative, CD56-bright natural killer cell, human	6 studies	21% ± 3%	Explore
effector memory CD8-positive, alpha-beta T cell	6 studies	22% ± 4%	Explore
endothelial cell of vascular tree	6 studies	19% ± 3%	Explore
CD8-positive, alpha-beta memory T cell	6 studies	26% ± 7%	Explore
plasma cell	5 studies	28% ± 12%	Explore
precursor B cell	5 studies	30% ± 8%	Explore
endothelial cell of lymphatic vessel	5 studies	20% ± 4%	Explore
effector CD4-positive, alpha-beta T cell	5 studies	21% ± 3%	Explore
secretory cell	5 studies	22% ± 10%	Explore
plasmablast	4 studies	48% ± 19%	Explore
leukocyte	4 studies	27% ± 5%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	4 studies	20% ± 2%	Explore
mononuclear phagocyte	4 studies	26% ± 10%	Explore
exhausted T cell	4 studies	27% ± 5%	Explore
capillary endothelial cell	4 studies	17% ± 1%	Explore
T follicular helper cell	4 studies	17% ± 2%	Explore
abnormal cell	4 studies	22% ± 6%	Explore
mast cell	3 studies	16% ± 1%	Explore
pancreatic A cell	3 studies	36% ± 8%	Explore
kidney loop of Henle epithelial cell	3 studies	19% ± 2%	Explore
placental villous trophoblast	3 studies	51% ± 9%	Explore
mucosal invariant T cell	3 studies	18% ± 1%	Explore
innate lymphoid cell	3 studies	26% ± 6%	Explore
club cell	3 studies	18% ± 3%	Explore
immature B cell	3 studies	30% ± 7%	Explore
pro-B cell	3 studies	29% ± 3%	Explore
germinal center B cell	3 studies	30% ± 6%	Explore
intermediate monocyte	3 studies	31% ± 14%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	28% ± 4%	Explore
endothelial cell of artery	3 studies	18% ± 2%	Explore
luminal hormone-sensing cell of mammary gland	3 studies	19% ± 1%	Explore
granulocyte	3 studies	18% ± 1%	Explore
type I pneumocyte	3 studies	27% ± 7%	Explore
GABAergic neuron	3 studies	23% ± 4%	Explore
glutamatergic neuron	3 studies	31% ± 3%	Explore
pancreatic ductal cell	3 studies	38% ± 15%	Explore
group 3 innate lymphoid cell	3 studies	24% ± 11%	Explore
oligodendrocyte	3 studies	18% ± 2%	Explore
double negative thymocyte	3 studies	28% ± 14%	Explore
oligodendrocyte precursor cell	3 studies	19% ± 0%	Explore
CD4-positive, alpha-beta memory T cell	3 studies	26% ± 4%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	9 studies	26% ± 9%	Explore
peripheral blood	8 studies	24% ± 9%	Explore
brain	5 studies	23% ± 4%	Explore
eye	4 studies	21% ± 7%	Explore
breast	4 studies	17% ± 1%	Explore
pancreas	3 studies	34% ± 8%	Explore
kidney	3 studies	19% ± 3%	Explore
placenta	3 studies	24% ± 7%	Explore
intestine	3 studies	24% ± 10%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	3446.27	1445 / 1445	100%	49.78	183 / 183
intestine	100%	3421.03	966 / 966	100%	50.66	527 / 527
lung	100%	3032.65	578 / 578	100%	52.90	1155 / 1155
stomach	100%	2075.67	359 / 359	100%	45.32	286 / 286
uterus	100%	2790.59	170 / 170	100%	61.10	459 / 459
brain	100%	2343.60	2641 / 2642	100%	52.45	705 / 705
bladder	100%	2768.86	21 / 21	100%	54.19	503 / 504
ovary	100%	2147.78	180 / 180	100%	33.90	429 / 430
breast	100%	2941.39	459 / 459	100%	53.91	1115 / 1118
prostate	100%	2525.36	245 / 245	100%	33.04	500 / 502
thymus	100%	2649.00	653 / 653	100%	47.22	602 / 605
skin	100%	3325.26	1809 / 1809	99%	42.99	468 / 472
kidney	100%	2784.81	89 / 89	99%	33.02	893 / 901
adrenal gland	100%	2450.55	258 / 258	99%	30.87	227 / 230
liver	100%	1144.54	225 / 226	99%	26.63	400 / 406
pancreas	98%	1157.88	323 / 328	99%	41.13	176 / 178
adipose	100%	3229.39	1204 / 1204	0%	0	0 / 0
blood vessel	100%	3293.04	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	70.93	29 / 29
muscle	100%	3455.15	803 / 803	0%	0	0 / 0
spleen	100%	2725.47	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	57.61	45 / 45
ureter	0%	0	0 / 0	100%	27.03	1 / 1
heart	99%	2813.49	852 / 861	0%	0	0 / 0
peripheral blood	98%	2689.42	915 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	94%	27.16	75 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006281	Biological process	DNA repair
GO_0070979	Biological process	protein K11-linked ubiquitination
GO_0000209	Biological process	protein polyubiquitination
GO_0006511	Biological process	ubiquitin-dependent protein catabolic process
GO_0009411	Biological process	response to UV
GO_0006301	Biological process	postreplication repair
GO_0006338	Biological process	chromatin remodeling
GO_0070936	Biological process	protein K48-linked ubiquitination
GO_1901526	Biological process	positive regulation of mitophagy
GO_0000086	Biological process	G2/M transition of mitotic cell cycle
GO_0043161	Biological process	proteasome-mediated ubiquitin-dependent protein catabolic process
GO_0033503	Cellular component	HULC complex
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0000785	Cellular component	chromatin
GO_0031625	Molecular function	ubiquitin protein ligase binding
GO_0005524	Molecular function	ATP binding
GO_0004842	Molecular function	ubiquitin-protein transferase activity
GO_0061631	Molecular function	ubiquitin conjugating enzyme activity
GO_0005515	Molecular function	protein binding
GO_0043130	Molecular function	ubiquitin binding

IV. Literature review

[source]

Gene name	UBE2A
Protein name	Ubiquitin-conjugating enzyme E2 A (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme A) (RAD6 homolog A) (HR6A) (hHR6A) (Ubiquitin carrier protein A) (Ubiquitin-protein ligase A) E2 ubiquitin-conjugating enzyme (EC 2.3.2.23) Ubiquitin conjugating enzyme E2 A
Synonyms	RAD6A
Description	FUNCTION: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11', as well as 'Lys-48'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA. .
Accessions	ENST00000371558.7 [P49459-1] A0A0D9SEZ6 A0A8Q3SIL6 A0A0D9SG71 A0A0D9SF75 ENST00000625938.2 [P49459-2] ENST00000696539.1 A0A0R4J2E5 ENST00000346330.6 ENST00000628549.1 ENST00000629303.2 P49459 ENST00000631185.2 ENST00000696533.1 ENST00000696534.1 [P49459-1] ENST00000630695.2 [P49459-3]

UBE2A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review