TUT4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0071076Biological processRNA 3' uridylation
GO_0141008Biological processretrotransposon silencing by mRNA destabilization
GO_0071044Biological processhistone mRNA catabolic process
GO_0010587Biological processmiRNA catabolic process
GO_1990074Biological processpolyuridylation-dependent mRNA catabolic process
GO_0031054Biological processpre-miRNA processing
GO_0001556Biological processoocyte maturation
GO_0019827Biological processstem cell population maintenance
GO_0010586Biological processmiRNA metabolic process
GO_0031123Biological processRNA 3'-end processing
GO_0005730Cellular componentnucleolus
GO_0005615Cellular componentextracellular space
GO_0036464Cellular componentcytoplasmic ribonucleoprotein granule
GO_0070062Cellular componentextracellular exosome
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0008270Molecular functionzinc ion binding
GO_0003723Molecular functionRNA binding
GO_0050265Molecular functionRNA uridylyltransferase activity
GO_0035198Molecular functionmiRNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTUT4
Protein nameTerminal uridylyltransferase 4 (TUTase 4) (EC 2.7.7.52) (Zinc finger CCHC domain-containing protein 11)
Terminal uridylyl transferase 4
RNA uridylyltransferase (EC 2.7.7.52)
SynonymsKIAA0191
ZCCHC11
DescriptionFUNCTION: Uridylyltransferase that mediates the terminal uridylation of mRNAs with short (less than 25 nucleotides) poly(A) tails, hence facilitating global mRNA decay . Essential for both oocyte maturation and fertility. Through 3' terminal uridylation of mRNA, sculpts, with TUT7, the maternal transcriptome by eliminating transcripts during oocyte growth (By similarity). Involved in microRNA (miRNA)-induced gene silencing through uridylation of deadenylated miRNA targets. Also functions as an integral regulator of microRNA biogenesis using 3 different uridylation mechanisms . Acts as a suppressor of miRNA biogenesis by mediating the terminal uridylation of some miRNA precursors, including that of let-7 (pre-let-7), miR107, miR-143 and miR-200c. Uridylated miRNAs are not processed by Dicer and undergo degradation. Degradation of pre-let-7 contributes to the maintenance of embryonic stem (ES) cell pluripotency (By similarity). Also catalyzes the 3' uridylation of miR-26A, a miRNA that targets IL6 transcript. This abrogates the silencing of IL6 transcript, hence promoting cytokine expression . In the absence of LIN28A, TUT7 and TUT4 monouridylate group II pre-miRNAs, which includes most of pre-let7 members, that shapes an optimal 3' end overhang for efficient processing . Adds oligo-U tails to truncated pre-miRNAS with a 5' overhang which may promote rapid degradation of non-functional pre-miRNA species . May also suppress Toll-like receptor-induced NF-kappa-B activation via binding to T2BP . Does not play a role in replication-dependent histone mRNA degradation . Due to functional redundancy between TUT4 and TUT7, the identification of the specific role of each of these proteins is difficult (By similarity). TUT4 and TUT7 restrict retrotransposition of long interspersed element-1 (LINE-1) in cooperation with MOV10 counteracting the RNA chaperonne activity of L1RE1. TUT7 uridylates LINE-1 mRNAs in the cytoplasm which inhibits initiation of reverse transcription once in the nucleus, whereas uridylation by TUT4 destabilizes mRNAs in cytoplasmic ribonucleoprotein granules . .

AccessionsENST00000494469.5
E9PKX1
ENST00000470626.1
ENST00000473856.5
ENST00000531722.5
A0A0C4DFM7
H0YDZ6
ENST00000257177.9
E9PKY2
ENST00000484723.6
ENST00000524582.1
ENST00000355809.4
E9PQS7
X6R5G7
ENST00000528642.5
E9PRG2
ENST00000527941.5
E9PJN7
ENST00000528457.5
H0YCX5
H0YDJ1
ENST00000371544.7 [Q5TAX3-1]
Q5TAX3
H0YEE8
H0YF28
ENST00000471623.1
ENST00000474453.6
H0YEY0