TOP2B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030900Biological processforebrain development
GO_0001764Biological processneuron migration
GO_0071318Biological processcellular response to ATP
GO_0007409Biological processaxonogenesis
GO_0070301Biological processcellular response to hydrogen peroxide
GO_0006265Biological processDNA topological change
GO_0000712Biological processresolution of meiotic recombination intermediates
GO_0090398Biological processcellular senescence
GO_0000819Biological processsister chromatid segregation
GO_0030183Biological processB cell differentiation
GO_2001034Biological processpositive regulation of double-strand break repair via nonhomologous end joining
GO_0045870Biological processpositive regulation of single stranded viral RNA replication via double stranded DNA intermediate
GO_0005730Cellular componentnucleolus
GO_0000792Cellular componentheterochromatin
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_1990904Cellular componentribonucleoprotein complex
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0003682Molecular functionchromatin binding
GO_0003918Molecular functionDNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO_0043021Molecular functionribonucleoprotein complex binding
GO_0046872Molecular functionmetal ion binding
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTOP2B
Protein nameDNA topoisomerase II beta
DNA topoisomerase 2-beta (EC 5.6.2.2) (DNA topoisomerase II, beta isozyme)
DNA topoisomerase 2 (EC 5.6.2.2)
Alternative protein TOP2B
Synonyms
DescriptionFUNCTION: Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand. Plays a role in B-cell differentiation. .

FUNCTION: Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand. .

FUNCTION: Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand. .

FUNCTION: Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand. .

FUNCTION: Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand. .

FUNCTION: Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand. .

AccessionsL8E8K5
A0A8V8TPE3
Q71UH4
ENST00000413971.5
ENST00000699043.1
ENST00000264331.9 [Q02880-1]
E9PCY5
ENST00000699038.1
H7BZ82
A0A8V8TN33
ENST00000699037.1
ENST00000424225.1
ENST00000435706.6 [Q02880-2]
Q02880
A0A8V8TP20