TMEM147 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
fibroblast	26 studies	27% ± 12%	Explore
macrophage	22 studies	31% ± 10%	Explore
endothelial cell	20 studies	31% ± 13%	Explore
conventional dendritic cell	16 studies	29% ± 13%	Explore
classical monocyte	15 studies	26% ± 10%	Explore
epithelial cell	15 studies	38% ± 18%	Explore
pericyte	15 studies	23% ± 8%	Explore
non-classical monocyte	14 studies	28% ± 13%	Explore
CD4-positive, alpha-beta T cell	14 studies	19% ± 5%	Explore
smooth muscle cell	14 studies	24% ± 6%	Explore
basal cell	13 studies	31% ± 15%	Explore
connective tissue cell	13 studies	29% ± 10%	Explore
plasma cell	12 studies	38% ± 13%	Explore
natural killer cell	12 studies	22% ± 7%	Explore
endothelial cell of lymphatic vessel	12 studies	26% ± 11%	Explore
myofibroblast cell	11 studies	25% ± 8%	Explore
monocyte	11 studies	23% ± 8%	Explore
gamma-delta T cell	11 studies	21% ± 9%	Explore
CD8-positive, alpha-beta T cell	10 studies	21% ± 5%	Explore
capillary endothelial cell	10 studies	21% ± 4%	Explore
plasmacytoid dendritic cell	10 studies	26% ± 9%	Explore
B cell	9 studies	21% ± 5%	Explore
CD16-negative, CD56-bright natural killer cell, human	9 studies	20% ± 5%	Explore
vein endothelial cell	9 studies	20% ± 4%	Explore
endothelial cell of vascular tree	9 studies	24% ± 6%	Explore
ciliated cell	9 studies	35% ± 16%	Explore
plasmablast	8 studies	39% ± 22%	Explore
secretory cell	8 studies	25% ± 12%	Explore
dendritic cell	8 studies	39% ± 24%	Explore
myeloid cell	8 studies	28% ± 10%	Explore
mast cell	8 studies	19% ± 4%	Explore
mature NK T cell	7 studies	17% ± 1%	Explore
endothelial cell of artery	7 studies	23% ± 5%	Explore
abnormal cell	7 studies	35% ± 14%	Explore
mucosal invariant T cell	7 studies	18% ± 2%	Explore
type I pneumocyte	7 studies	28% ± 13%	Explore
regulatory T cell	7 studies	19% ± 3%	Explore
CD4-positive, alpha-beta memory T cell	6 studies	19% ± 3%	Explore
CD8-positive, alpha-beta memory T cell	6 studies	18% ± 2%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	6 studies	20% ± 4%	Explore
epithelial cell of proximal tubule	6 studies	27% ± 10%	Explore
kidney loop of Henle epithelial cell	6 studies	26% ± 7%	Explore
progenitor cell	6 studies	24% ± 4%	Explore
renal alpha-intercalated cell	6 studies	37% ± 7%	Explore
goblet cell	6 studies	23% ± 10%	Explore
memory B cell	6 studies	20% ± 3%	Explore
alveolar macrophage	5 studies	24% ± 6%	Explore
CD16-positive, CD56-dim natural killer cell, human	5 studies	18% ± 2%	Explore
T cell	5 studies	24% ± 9%	Explore
enteroendocrine cell	5 studies	31% ± 14%	Explore
transit amplifying cell	5 studies	22% ± 3%	Explore
type II pneumocyte	5 studies	34% ± 18%	Explore
innate lymphoid cell	5 studies	18% ± 2%	Explore
hematopoietic precursor cell	4 studies	37% ± 14%	Explore
pancreatic A cell	4 studies	56% ± 12%	Explore
type B pancreatic cell	4 studies	45% ± 13%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	4 studies	18% ± 2%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	39% ± 4%	Explore
intestinal crypt stem cell	4 studies	27% ± 6%	Explore
mesothelial cell	4 studies	35% ± 21%	Explore
naive B cell	4 studies	19% ± 3%	Explore
retinal ganglion cell	4 studies	51% ± 30%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	31% ± 7%	Explore
neuron	4 studies	38% ± 20%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	20% ± 5%	Explore
mononuclear phagocyte	4 studies	31% ± 18%	Explore
duct epithelial cell	3 studies	20% ± 4%	Explore
ionocyte	3 studies	21% ± 4%	Explore
effector memory CD8-positive, alpha-beta T cell	3 studies	22% ± 2%	Explore
neural crest cell	3 studies	24% ± 4%	Explore
IgG plasma cell	3 studies	30% ± 3%	Explore
common myeloid progenitor	3 studies	32% ± 14%	Explore
hematopoietic stem cell	3 studies	21% ± 5%	Explore
club cell	3 studies	34% ± 13%	Explore
amacrine cell	3 studies	35% ± 15%	Explore
astrocyte	3 studies	31% ± 16%	Explore
retina horizontal cell	3 studies	28% ± 15%	Explore
retinal cone cell	3 studies	45% ± 19%	Explore
retinal rod cell	3 studies	29% ± 11%	Explore
intraepithelial lymphocyte	3 studies	21% ± 4%	Explore
Mueller cell	3 studies	29% ± 7%	Explore
erythroblast	3 studies	30% ± 11%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	20% ± 3%	Explore
intermediate monocyte	3 studies	37% ± 8%	Explore
glutamatergic neuron	3 studies	22% ± 6%	Explore
pancreatic ductal cell	3 studies	46% ± 5%	Explore
oligodendrocyte precursor cell	3 studies	28% ± 8%	Explore
glial cell	3 studies	31% ± 19%	Explore
group 3 innate lymphoid cell	3 studies	22% ± 8%	Explore
keratinocyte	3 studies	22% ± 5%	Explore
T-helper 17 cell	3 studies	20% ± 3%	Explore
progenitor cell of mammary luminal epithelium	3 studies	22% ± 1%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	13 studies	28% ± 11%	Explore
peripheral blood	11 studies	22% ± 6%	Explore
intestine	8 studies	23% ± 11%	Explore
kidney	7 studies	23% ± 4%	Explore
eye	5 studies	28% ± 14%	Explore
pancreas	4 studies	48% ± 15%	Explore
breast	4 studies	22% ± 4%	Explore
brain	4 studies	26% ± 8%	Explore
placenta	3 studies	27% ± 10%	Explore
uterus	3 studies	35% ± 15%	Explore
lymph node	3 studies	24% ± 12%	Explore
liver	3 studies	28% ± 14%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	2729.99	1445 / 1445	100%	72.75	183 / 183
ovary	100%	2515.23	180 / 180	100%	142.65	430 / 430
brain	100%	2199.23	2638 / 2642	100%	97.97	705 / 705
thymus	100%	4087.99	653 / 653	100%	126.52	604 / 605
uterus	100%	2793.42	170 / 170	100%	133.82	458 / 459
kidney	100%	3219.01	89 / 89	100%	86.37	897 / 901
pancreas	100%	2860.66	328 / 328	99%	100.80	177 / 178
intestine	100%	2381.85	966 / 966	99%	129.78	524 / 527
adrenal gland	100%	5414.07	258 / 258	99%	141.55	228 / 230
lung	100%	2674.07	577 / 578	99%	111.46	1146 / 1155
prostate	100%	2217.37	245 / 245	99%	98.39	497 / 502
stomach	100%	2386.55	359 / 359	99%	110.40	283 / 286
bladder	100%	2919.52	21 / 21	99%	158.82	498 / 504
breast	100%	2705.46	459 / 459	99%	120.51	1104 / 1118
skin	100%	4147.79	1809 / 1809	98%	199.53	464 / 472
liver	97%	1313.81	220 / 226	98%	80.25	397 / 406
adipose	100%	2677.79	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	246.50	80 / 80
lymph node	0%	0	0 / 0	100%	89.31	29 / 29
muscle	100%	2873.26	803 / 803	0%	0	0 / 0
spleen	100%	2248.54	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	82.22	45 / 45
ureter	0%	0	0 / 0	100%	286.43	1 / 1
blood vessel	100%	2761.85	1332 / 1335	0%	0	0 / 0
heart	98%	2523.82	846 / 861	0%	0	0 / 0
peripheral blood	90%	1222.70	838 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0036228	Biological process	protein localization to nuclear inner membrane
GO_0160063	Biological process	multi-pass transmembrane protein insertion into ER membrane
GO_0160064	Cellular component	multi-pass translocon complex
GO_0032991	Cellular component	protein-containing complex
GO_0031965	Cellular component	nuclear membrane
GO_0005886	Cellular component	plasma membrane
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0043022	Molecular function	ribosome binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	TMEM147
Protein name	BOS complex subunit TMEM147 (Transmembrane protein 147) BOS complex subunit TMEM147 (Protein NIFIE 14) (Transmembrane protein 147) Transmembrane protein 147
Synonyms
Description	FUNCTION: Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes . The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions . Also acts as a negative regulator of CHRM3 function, most likely by interfering with its trafficking to the cell membrane . Negatively regulates CHRM3-mediated calcium mobilization and activation of RPS6KA1/p90RSK activity . Regulates LBR localization to the nucleus inner membrane . .
Accessions	ENST00000392204.6 [Q9BVK8-2] ENST00000222284.10 [Q9BVK8-1] ENST00000392205.2 Q9BVK8 A8MU21 ENST00000593027.6 K7ELX3

TMEM147 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review