TIMM13 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007605Biological processsensory perception of sound
GO_0006626Biological processprotein targeting to mitochondrion
GO_0045039Biological processprotein insertion into mitochondrial inner membrane
GO_0005758Cellular componentmitochondrial intermembrane space
GO_0042719Cellular componentmitochondrial intermembrane space protein transporter complex
GO_0005739Cellular componentmitochondrion
GO_0005743Cellular componentmitochondrial inner membrane
GO_0001650Cellular componentfibrillar center
GO_0005515Molecular functionprotein binding
GO_0008270Molecular functionzinc ion binding

IV. Literature review

[source]
Gene nameTIMM13
Protein nameMitochondrial import inner membrane translocase subunit Tim13
Mitochondrial import inner membrane translocase subunit
SynonymsTIMM13A
TIM13B
hCG_2039527
TIMM13B
DescriptionFUNCTION: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIMM8-TIMM13 complex mediates the import of proteins such as TIMM23, SLC25A12/ARALAR1 and SLC25A13/ARALAR2, while the predominant TIMM9-TIMM10 70 kDa complex mediates the import of much more proteins. .

FUNCTION: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. .

AccessionsENST00000591871.1
ENST00000215570.8
Q9Y5L4
K7EIT2