STOML2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0034982Biological processmitochondrial protein processing
GO_1990046Biological processstress-induced mitochondrial fusion
GO_0006874Biological processintracellular calcium ion homeostasis
GO_0050852Biological processT cell receptor signaling pathway
GO_0042776Biological processproton motive force-driven mitochondrial ATP synthesis
GO_0035710Biological processCD4-positive, alpha-beta T cell activation
GO_0032743Biological processpositive regulation of interleukin-2 production
GO_0051259Biological processprotein complex oligomerization
GO_0010876Biological processlipid localization
GO_0007005Biological processmitochondrion organization
GO_0001772Cellular componentimmunological synapse
GO_0005886Cellular componentplasma membrane
GO_0045121Cellular componentmembrane raft
GO_0005739Cellular componentmitochondrion
GO_0005758Cellular componentmitochondrial intermembrane space
GO_0005743Cellular componentmitochondrial inner membrane
GO_0015629Cellular componentactin cytoskeleton
GO_0042608Molecular functionT cell receptor binding
GO_0051020Molecular functionGTPase binding
GO_1901612Molecular functioncardiolipin binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSTOML2
Protein nameStomatin like 2
Stomatin-like protein 2, mitochondrial (SLP-2) (EPB72-like protein 2) (Paraprotein target 7) (Paratarg-7)
SynonymsSLP2
HSPC108
DescriptionFUNCTION: Mitochondrial protein that probably regulates the biogenesis and the activity of mitochondria. Stimulates cardiolipin biosynthesis, binds cardiolipin-enriched membranes where it recruits and stabilizes some proteins including prohibitin and may therefore act in the organization of functional microdomains in mitochondrial membranes. Through regulation of the mitochondrial function may play a role into several biological processes including cell migration, cell proliferation, T-cell activation, calcium homeostasis and cellular response to stress. May play a role in calcium homeostasis through negative regulation of calcium efflux from mitochondria. Required for mitochondrial hyperfusion a pro-survival cellular response to stress which results in increased ATP production by mitochondria. May also regulate the organization of functional domains at the plasma membrane and play a role in T-cell activation through association with the T-cell receptor signaling complex and its regulation. .

AccessionsENST00000619795.4
Q9UJZ1
ENST00000488050.1
ENST00000356493.10 [Q9UJZ1-1]
F2Z2I8
ENST00000452248.6 [Q9UJZ1-2]
A0A087WYB4