SRSF1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006376Biological processmRNA splice site recognition
GO_0006397Biological processmRNA processing
GO_0051028Biological processmRNA transport
GO_0033120Biological processpositive regulation of RNA splicing
GO_0000395Biological processmRNA 5'-splice site recognition
GO_0000380Biological processalternative mRNA splicing, via spliceosome
GO_0000398Biological processmRNA splicing, via spliceosome
GO_0097421Biological processliver regeneration
GO_0048709Biological processoligodendrocyte differentiation
GO_0043484Biological processregulation of RNA splicing
GO_0016607Cellular componentnuclear speck
GO_0035145Cellular componentexon-exon junction complex
GO_0005654Cellular componentnucleoplasm
GO_0005635Cellular componentnuclear envelope
GO_0005737Cellular componentcytoplasm
GO_0071013Cellular componentcatalytic step 2 spliceosome
GO_0005634Cellular componentnucleus
GO_0003729Molecular functionmRNA binding
GO_0044547Molecular functionDNA topoisomerase binding
GO_0003723Molecular functionRNA binding
GO_0043422Molecular functionprotein kinase B binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSRSF1
Protein nameSerine and arginine rich splicing factor 1
Serine and arginine rich splicing factor 1 (Splicing factor, arginine/serine-rich 1 (Splicing factor 2, alternate splicing factor), isoform CRA_f)
Serine/arginine-rich splicing factor 1 (Alternative-splicing factor 1) (ASF-1) (Splicing factor, arginine/serine-rich 1) (pre-mRNA-splicing factor SF2, P33 subunit)
Serine/arginine-rich splicing factor 1 (Splicing factor, arginine/serine-rich 1)
Serine and arginine rich splicing factor 1 transcript variant 5
SynonymshCG_1774411
SFRS1
SF2
OK/SW-cl.3
SF2P33
ASF
DescriptionFUNCTION: Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5'-splice site-containing pre-mRNA. Binds to purine-rich RNA sequences, either the octamer, 5'-RGAAGAAC-3' (r=A or G) or the decamers, AGGACAGAGC/AGGACGAAGC. Binds preferentially to the 5'-CGAGGCG-3' motif in vitro. Three copies of the octamer constitute a powerful splicing enhancer in vitro, the ASF/SF2 splicing enhancer (ASE) which can specifically activate ASE-dependent splicing. Isoform ASF-2 and isoform ASF-3 act as splicing repressors. May function as export adapter involved in mRNA nuclear export through the TAP/NXF1 pathway. .

AccessionsJ3KTL2
ENST00000584668.5
ENST00000582730.6 [Q07955-3]
ENST00000584773.5
ENST00000258962.5 [Q07955-1]
Q07955
A0A2I7N9Y9
J3KSW7
J3QQV5
ENST00000583741.1
ENST00000585096.1
J3KSR8
ENST00000581979.5 [Q07955-3]