SPCS3 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	32 studies	29% ± 10%	Explore
natural killer cell	31 studies	27% ± 10%	Explore
macrophage	30 studies	30% ± 9%	Explore
plasma cell	27 studies	59% ± 23%	Explore
CD8-positive, alpha-beta T cell	25 studies	28% ± 11%	Explore
classical monocyte	24 studies	33% ± 13%	Explore
conventional dendritic cell	22 studies	28% ± 13%	Explore
CD4-positive, alpha-beta T cell	20 studies	26% ± 10%	Explore
non-classical monocyte	19 studies	33% ± 14%	Explore
plasmacytoid dendritic cell	18 studies	50% ± 12%	Explore
regulatory T cell	18 studies	24% ± 5%	Explore
T cell	17 studies	25% ± 7%	Explore
monocyte	17 studies	29% ± 8%	Explore
gamma-delta T cell	15 studies	28% ± 9%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	29% ± 7%	Explore
mature NK T cell	14 studies	26% ± 9%	Explore
B cell	13 studies	28% ± 16%	Explore
CD16-negative, CD56-bright natural killer cell, human	13 studies	26% ± 7%	Explore
dendritic cell	12 studies	36% ± 25%	Explore
plasmablast	12 studies	68% ± 22%	Explore
capillary endothelial cell	12 studies	22% ± 4%	Explore
mucosal invariant T cell	12 studies	31% ± 8%	Explore
myeloid cell	12 studies	31% ± 14%	Explore
mast cell	11 studies	30% ± 9%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	11 studies	25% ± 7%	Explore
vein endothelial cell	11 studies	23% ± 5%	Explore
memory B cell	11 studies	18% ± 2%	Explore
endothelial cell of lymphatic vessel	10 studies	24% ± 7%	Explore
fibroblast	10 studies	24% ± 9%	Explore
CD4-positive, alpha-beta memory T cell	10 studies	27% ± 8%	Explore
CD8-positive, alpha-beta memory T cell	10 studies	30% ± 7%	Explore
endothelial cell of artery	10 studies	23% ± 3%	Explore
naive B cell	9 studies	19% ± 4%	Explore
IgG plasma cell	9 studies	54% ± 12%	Explore
secretory cell	8 studies	25% ± 14%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	8 studies	23% ± 6%	Explore
effector memory CD8-positive, alpha-beta T cell	8 studies	30% ± 9%	Explore
IgA plasma cell	8 studies	53% ± 12%	Explore
basal cell	8 studies	28% ± 14%	Explore
endothelial cell of vascular tree	8 studies	28% ± 7%	Explore
alveolar macrophage	7 studies	27% ± 5%	Explore
epithelial cell	7 studies	39% ± 21%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	38% ± 13%	Explore
innate lymphoid cell	6 studies	24% ± 4%	Explore
T follicular helper cell	6 studies	22% ± 4%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	32% ± 12%	Explore
microglial cell	6 studies	23% ± 7%	Explore
pericyte	6 studies	20% ± 6%	Explore
effector CD4-positive, alpha-beta T cell	5 studies	32% ± 5%	Explore
leukocyte	5 studies	30% ± 9%	Explore
mononuclear phagocyte	5 studies	31% ± 10%	Explore
hematopoietic precursor cell	5 studies	38% ± 8%	Explore
oligodendrocyte	5 studies	26% ± 9%	Explore
oligodendrocyte precursor cell	5 studies	27% ± 10%	Explore
connective tissue cell	5 studies	20% ± 4%	Explore
pancreatic A cell	4 studies	26% ± 4%	Explore
exhausted T cell	4 studies	37% ± 13%	Explore
abnormal cell	4 studies	18% ± 2%	Explore
neuron	4 studies	22% ± 9%	Explore
lymphocyte	4 studies	31% ± 11%	Explore
type II pneumocyte	4 studies	27% ± 19%	Explore
intermediate monocyte	4 studies	43% ± 18%	Explore
goblet cell	4 studies	29% ± 7%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	25% ± 6%	Explore
smooth muscle cell	3 studies	23% ± 5%	Explore
type I pneumocyte	3 studies	25% ± 10%	Explore
ionocyte	3 studies	30% ± 2%	Explore
respiratory goblet cell	3 studies	27% ± 13%	Explore
type B pancreatic cell	3 studies	45% ± 9%	Explore
glomerular endothelial cell	3 studies	30% ± 6%	Explore
extravillous trophoblast	3 studies	40% ± 6%	Explore
common myeloid progenitor	3 studies	27% ± 5%	Explore
megakaryocyte	3 studies	28% ± 8%	Explore
club cell	3 studies	24% ± 7%	Explore
tissue-resident macrophage	3 studies	27% ± 8%	Explore
ciliated cell	3 studies	44% ± 12%	Explore
CD4-positive helper T cell	3 studies	28% ± 9%	Explore
IgM plasma cell	3 studies	49% ± 7%	Explore
GABAergic neuron	3 studies	40% ± 6%	Explore
glutamatergic neuron	3 studies	54% ± 10%	Explore
acinar cell	3 studies	53% ± 17%	Explore
pancreatic ductal cell	3 studies	31% ± 11%	Explore
granulocyte	3 studies	23% ± 6%	Explore
granulocyte monocyte progenitor cell	3 studies	42% ± 10%	Explore
neutrophil	3 studies	19% ± 2%	Explore
enteroendocrine cell	3 studies	26% ± 7%	Explore
group 3 innate lymphoid cell	3 studies	34% ± 12%	Explore
T-helper 17 cell	3 studies	36% ± 15%	Explore
interneuron	3 studies	34% ± 17%	Explore
T-helper 1 cell	3 studies	32% ± 6%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	23% ± 5%	Explore
central memory CD8-positive, alpha-beta T cell	3 studies	24% ± 5%	Explore
double negative thymocyte	3 studies	35% ± 5%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	16 studies	29% ± 11%	Explore
lung	13 studies	26% ± 14%	Explore
intestine	8 studies	22% ± 8%	Explore
brain	7 studies	32% ± 12%	Explore
kidney	5 studies	20% ± 4%	Explore
bone marrow	5 studies	27% ± 5%	Explore
liver	5 studies	23% ± 11%	Explore
pancreas	4 studies	33% ± 9%	Explore
uterus	4 studies	28% ± 11%	Explore
placenta	3 studies	30% ± 11%	Explore
breast	3 studies	17% ± 1%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	100%	5601.90	459 / 459	100%	66.31	1118 / 1118
esophagus	100%	4500.04	1445 / 1445	100%	59.97	183 / 183
lung	100%	7724.58	578 / 578	100%	62.96	1155 / 1155
prostate	100%	5260.10	245 / 245	100%	74.61	502 / 502
stomach	100%	6052.45	359 / 359	100%	59.77	286 / 286
thymus	100%	6620.98	653 / 653	100%	64.21	604 / 605
bladder	100%	6402.10	21 / 21	100%	58.73	503 / 504
uterus	100%	6556.71	170 / 170	100%	58.40	458 / 459
intestine	100%	7313.65	966 / 966	100%	61.20	525 / 527
ovary	100%	4216.79	180 / 180	100%	41.90	428 / 430
kidney	100%	4297.21	89 / 89	99%	61.38	896 / 901
pancreas	100%	9072.12	328 / 328	99%	58.62	177 / 178
liver	100%	4628.07	226 / 226	99%	31.57	401 / 406
brain	99%	3540.18	2607 / 2642	100%	45.20	705 / 705
adrenal gland	100%	3945.37	258 / 258	98%	42.88	226 / 230
skin	100%	6991.58	1807 / 1809	97%	56.33	456 / 472
adipose	100%	6159.82	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	59.12	29 / 29
spleen	100%	8641.18	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	55.67	45 / 45
ureter	0%	0	0 / 0	100%	28.94	1 / 1
blood vessel	100%	5497.35	1332 / 1335	0%	0	0 / 0
muscle	100%	3109.25	800 / 803	0%	0	0 / 0
heart	100%	4781.22	857 / 861	0%	0	0 / 0
peripheral blood	92%	5315.00	857 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	88%	33.57	70 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

IV. Literature review

[source]

Gene name	SPCS3
Protein name	Signal peptidase complex subunit 3 (Microsomal signal peptidase 22/23 kDa subunit) (SPC22/23) (SPase 22/23 kDa subunit)
Synonyms	SPC22 UNQ1841/PRO3567
Description	FUNCTION: Essential component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum . Essential for the SPC catalytic activity, possibly by stabilizing and positioning the active center of the complex close to the lumenal surface (By similarity). .; FUNCTION: (Microbial infection) Plays an important role in virion production of flaviviruses such as West Nile virus, Japanese enchephalitis virus, Dengue virus type 2 and Yellow Fever virus. .
Accessions	ENST00000503362.2 P61009

GO_0006465	Biological process	signal peptide processing
GO_0045047	Biological process	protein targeting to ER
GO_0006508	Biological process	proteolysis
GO_0019082	Biological process	viral protein processing
GO_0005783	Cellular component	endoplasmic reticulum
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0005787	Cellular component	signal peptidase complex
GO_0005515	Molecular function	protein binding

SPCS3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review