SNRPA report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0000398Biological processmRNA splicing, via spliceosome
GO_0046540Cellular componentU4/U6 x U5 tri-snRNP complex
GO_0005654Cellular componentnucleoplasm
GO_0005685Cellular componentU1 snRNP
GO_0005681Cellular componentspliceosomal complex
GO_0005634Cellular componentnucleus
GO_1990446Molecular functionU1 snRNP binding
GO_0003677Molecular functionDNA binding
GO_0030619Molecular functionU1 snRNA binding
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameSNRPA
Protein nameU1 small nuclear ribonucleoprotein A (U1 snRNP A) (U1-A) (U1A)
Small nuclear ribonucleoprotein polypeptide A
Synonyms
DescriptionFUNCTION: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1 snRNP is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. SNRPA binds stem loop II of U1 snRNA. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. May bind preferentially to the 5'-UGCAC-3' motif on RNAs. .

AccessionsP09012
M0R268
ENST00000599362.5
M0R0G9
M0QZG7
M0R221
ENST00000601253.5
M0QXK2
ENST00000243563.8
ENST00000601545.5
M0R2B8
ENST00000601393.1
ENST00000597353.5
ENST00000600456.1