SMC3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0034089Biological processestablishment of meiotic sister chromatid cohesion
GO_0007062Biological processsister chromatid cohesion
GO_0006281Biological processDNA repair
GO_0000278Biological processmitotic cell cycle
GO_0007064Biological processmitotic sister chromatid cohesion
GO_0051301Biological processcell division
GO_0034087Biological processestablishment of mitotic sister chromatid cohesion
GO_0090307Biological processmitotic spindle assembly
GO_0051321Biological processmeiotic cell cycle
GO_0019827Biological processstem cell population maintenance
GO_0006275Biological processregulation of DNA replication
GO_0000775Cellular componentchromosome, centromeric region
GO_0097431Cellular componentmitotic spindle pole
GO_0008278Cellular componentcohesin complex
GO_0005654Cellular componentnucleoplasm
GO_0016363Cellular componentnuclear matrix
GO_0005829Cellular componentcytosol
GO_0030892Cellular componentmitotic cohesin complex
GO_0030893Cellular componentmeiotic cohesin complex
GO_0000800Cellular componentlateral element
GO_0005694Cellular componentchromosome
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0048487Molecular functionbeta-tubulin binding
GO_0003682Molecular functionchromatin binding
GO_0003690Molecular functiondouble-stranded DNA binding
GO_0003777Molecular functionmicrotubule motor activity
GO_0005524Molecular functionATP binding
GO_0046982Molecular functionprotein heterodimerization activity
GO_0070840Molecular functiondynein complex binding
GO_0036033Molecular functionmediator complex binding
GO_0005515Molecular functionprotein binding
GO_0016887Molecular functionATP hydrolysis activity

IV. Literature review

[source]
Gene nameSMC3
Protein nameStructural maintenance of chromosomes protein 3 (SMC protein 3) (SMC-3) (Basement membrane-associated chondroitin proteoglycan) (Bamacan) (Chondroitin sulfate proteoglycan 6) (Chromosome-associated polypeptide) (hCAP)
Structural maintenance of chromosomes protein
SynonymsSMC3L1
BAM
BMH
CSPG6
DescriptionFUNCTION: Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex also plays an important role in spindle pole assembly during mitosis and in chromosomes movement. .

FUNCTION: Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex also plays an important role in spindle pole assembly during mitosis and in chromosomes movement. .

AccessionsQ86VX4
Q9UQE7
ENST00000361804.5