SMARCC1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030071Biological processregulation of mitotic metaphase/anaphase transition
GO_0032435Biological processnegative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO_0045582Biological processpositive regulation of T cell differentiation
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0009887Biological processanimal organ morphogenesis
GO_2000045Biological processregulation of G1/S transition of mitotic cell cycle
GO_0045663Biological processpositive regulation of myoblast differentiation
GO_0030850Biological processprostate gland development
GO_0006338Biological processchromatin remodeling
GO_0070316Biological processregulation of G0 to G1 transition
GO_1902459Biological processpositive regulation of stem cell population maintenance
GO_0045597Biological processpositive regulation of cell differentiation
GO_0008286Biological processinsulin receptor signaling pathway
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_2000819Biological processregulation of nucleotide-excision repair
GO_0045596Biological processnegative regulation of cell differentiation
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0006337Biological processnucleosome disassembly
GO_2000781Biological processpositive regulation of double-strand break repair
GO_0007399Biological processnervous system development
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0140288Cellular componentGBAF complex
GO_0071565Cellular componentnBAF complex
GO_0071564Cellular componentnpBAF complex
GO_0000776Cellular componentkinetochore
GO_0032991Cellular componentprotein-containing complex
GO_0016514Cellular componentSWI/SNF complex
GO_0005654Cellular componentnucleoplasm
GO_0001741Cellular componentXY body
GO_0016363Cellular componentnuclear matrix
GO_0016586Cellular componentRSC-type complex
GO_0035060Cellular componentbrahma complex
GO_0005737Cellular componentcytoplasm
GO_0001673Cellular componentmale germ cell nucleus
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0042393Molecular functionhistone binding
GO_0031492Molecular functionnucleosomal DNA binding
GO_0003713Molecular functiontranscription coactivator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSMARCC1
Protein nameSWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1
SWI/SNF complex subunit SMARCC1 (BRG1-associated factor 155) (BAF155) (SWI/SNF complex 155 kDa subunit) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 1)
SMARCC1 protein
SynonymsBAF155
DescriptionFUNCTION: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. May stimulate the ATPase activity of the catalytic subunit of the complex . Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). .

AccessionsQ05BW5
Q58EY4
ENST00000454240.1
ENST00000254480.10
Q92922
Q05CR1
F8WE13