SERINC1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	41 studies	33% ± 13%	Explore
fibroblast	34 studies	30% ± 12%	Explore
macrophage	30 studies	27% ± 8%	Explore
pericyte	27 studies	29% ± 11%	Explore
natural killer cell	23 studies	22% ± 6%	Explore
smooth muscle cell	22 studies	25% ± 9%	Explore
T cell	18 studies	23% ± 10%	Explore
regulatory T cell	18 studies	26% ± 7%	Explore
classical monocyte	17 studies	25% ± 10%	Explore
non-classical monocyte	17 studies	27% ± 11%	Explore
CD8-positive, alpha-beta T cell	17 studies	24% ± 6%	Explore
CD4-positive, alpha-beta T cell	16 studies	24% ± 6%	Explore
mast cell	15 studies	24% ± 7%	Explore
endothelial cell of lymphatic vessel	15 studies	33% ± 13%	Explore
astrocyte	14 studies	26% ± 8%	Explore
oligodendrocyte	14 studies	34% ± 10%	Explore
B cell	13 studies	20% ± 4%	Explore
connective tissue cell	13 studies	24% ± 7%	Explore
mature NK T cell	13 studies	22% ± 6%	Explore
capillary endothelial cell	13 studies	29% ± 8%	Explore
monocyte	12 studies	23% ± 6%	Explore
CD16-positive, CD56-dim natural killer cell, human	12 studies	25% ± 5%	Explore
gamma-delta T cell	12 studies	28% ± 7%	Explore
CD8-positive, alpha-beta memory T cell	11 studies	26% ± 7%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	11 studies	23% ± 7%	Explore
glutamatergic neuron	11 studies	52% ± 18%	Explore
endothelial cell of artery	11 studies	30% ± 6%	Explore
plasmacytoid dendritic cell	11 studies	25% ± 7%	Explore
myofibroblast cell	11 studies	26% ± 8%	Explore
vein endothelial cell	11 studies	27% ± 6%	Explore
type I pneumocyte	10 studies	31% ± 13%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	10 studies	23% ± 6%	Explore
GABAergic neuron	10 studies	48% ± 22%	Explore
CD16-negative, CD56-bright natural killer cell, human	10 studies	22% ± 5%	Explore
neuron	10 studies	46% ± 19%	Explore
memory B cell	10 studies	21% ± 5%	Explore
endothelial cell of vascular tree	10 studies	28% ± 9%	Explore
naive B cell	9 studies	21% ± 5%	Explore
microglial cell	9 studies	23% ± 6%	Explore
epithelial cell	9 studies	34% ± 19%	Explore
basal cell	9 studies	27% ± 7%	Explore
oligodendrocyte precursor cell	8 studies	26% ± 10%	Explore
conventional dendritic cell	8 studies	26% ± 7%	Explore
mucosal invariant T cell	8 studies	29% ± 5%	Explore
ciliated cell	8 studies	25% ± 13%	Explore
alveolar macrophage	7 studies	27% ± 9%	Explore
effector memory CD8-positive, alpha-beta T cell	7 studies	26% ± 6%	Explore
myeloid cell	7 studies	28% ± 14%	Explore
CD4-positive, alpha-beta memory T cell	7 studies	26% ± 7%	Explore
leukocyte	6 studies	22% ± 5%	Explore
abnormal cell	6 studies	31% ± 18%	Explore
amacrine cell	6 studies	44% ± 15%	Explore
T follicular helper cell	6 studies	22% ± 5%	Explore
secretory cell	5 studies	24% ± 10%	Explore
mononuclear phagocyte	5 studies	22% ± 6%	Explore
retinal ganglion cell	5 studies	66% ± 27%	Explore
dendritic cell	5 studies	31% ± 14%	Explore
neutrophil	5 studies	20% ± 3%	Explore
interneuron	5 studies	58% ± 21%	Explore
type II pneumocyte	4 studies	25% ± 8%	Explore
pancreatic A cell	4 studies	55% ± 21%	Explore
type B pancreatic cell	4 studies	60% ± 29%	Explore
effector CD8-positive, alpha-beta T cell	4 studies	21% ± 4%	Explore
glomerular endothelial cell	4 studies	42% ± 7%	Explore
epithelial cell of proximal tubule	4 studies	20% ± 2%	Explore
kidney loop of Henle epithelial cell	4 studies	32% ± 8%	Explore
retina horizontal cell	4 studies	49% ± 11%	Explore
Mueller cell	4 studies	28% ± 7%	Explore
mesothelial cell	4 studies	28% ± 12%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	28% ± 7%	Explore
innate lymphoid cell	4 studies	23% ± 3%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	23% ± 2%	Explore
enteroendocrine cell	4 studies	29% ± 13%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	21% ± 6%	Explore
ionocyte	3 studies	31% ± 3%	Explore
squamous epithelial cell	3 studies	41% ± 23%	Explore
pancreatic D cell	3 studies	49% ± 26%	Explore
exhausted T cell	3 studies	24% ± 2%	Explore
plasmablast	3 studies	27% ± 8%	Explore
podocyte	3 studies	47% ± 15%	Explore
retinal bipolar neuron	3 studies	39% ± 12%	Explore
GABAergic interneuron	3 studies	36% ± 13%	Explore
GABAergic amacrine cell	3 studies	42% ± 15%	Explore
plasma cell	3 studies	24% ± 5%	Explore
club cell	3 studies	27% ± 10%	Explore
retinal cone cell	3 studies	52% ± 9%	Explore
retinal pigment epithelial cell	3 studies	39% ± 22%	Explore
retinal rod cell	3 studies	27% ± 7%	Explore
tissue-resident macrophage	3 studies	25% ± 7%	Explore
lymphocyte	3 studies	35% ± 2%	Explore
OFF-bipolar cell	3 studies	37% ± 11%	Explore
ON-bipolar cell	3 studies	45% ± 11%	Explore
rod bipolar cell	3 studies	41% ± 10%	Explore
luminal cell of prostate epithelium	3 studies	23% ± 4%	Explore
muscle cell	3 studies	28% ± 8%	Explore
pancreatic ductal cell	3 studies	56% ± 26%	Explore
granulocyte	3 studies	26% ± 5%	Explore
goblet cell	3 studies	30% ± 11%	Explore
glial cell	3 studies	24% ± 6%	Explore
group 3 innate lymphoid cell	3 studies	28% ± 5%	Explore
melanocyte	3 studies	24% ± 5%	Explore
adipocyte	3 studies	33% ± 20%	Explore
erythrocyte	3 studies	27% ± 12%	Explore
double negative thymocyte	3 studies	32% ± 6%	Explore
hepatocyte	3 studies	38% ± 22%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	18 studies	38% ± 17%	Explore
lung	13 studies	24% ± 8%	Explore
peripheral blood	13 studies	25% ± 6%	Explore
eye	9 studies	28% ± 10%	Explore
kidney	6 studies	24% ± 6%	Explore
intestine	5 studies	20% ± 7%	Explore
uterus	5 studies	28% ± 10%	Explore
pancreas	4 studies	51% ± 24%	Explore
bone marrow	4 studies	19% ± 3%	Explore
breast	4 studies	20% ± 5%	Explore
adipose	3 studies	22% ± 4%	Explore
lymph node	3 studies	22% ± 1%	Explore
liver	3 studies	27% ± 8%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	31789.16	2642 / 2642	100%	561.34	704 / 705
breast	100%	19779.31	459 / 459	99%	334.79	1108 / 1118
lung	100%	16384.15	576 / 578	99%	182.35	1146 / 1155
esophagus	99%	12737.75	1436 / 1445	99%	163.51	182 / 183
thymus	100%	16439.92	653 / 653	98%	358.26	592 / 605
adrenal gland	100%	19830.07	258 / 258	98%	588.88	225 / 230
prostate	100%	10527.49	244 / 245	98%	263.94	492 / 502
kidney	100%	9605.08	89 / 89	97%	321.87	873 / 901
stomach	100%	9580.12	358 / 359	97%	140.61	277 / 286
intestine	100%	13576.32	965 / 966	95%	138.41	499 / 527
uterus	100%	16463.99	170 / 170	94%	142.14	432 / 459
skin	100%	13357.29	1806 / 1809	94%	220.63	444 / 472
bladder	100%	13535.24	21 / 21	92%	129.83	465 / 504
liver	98%	7438.69	221 / 226	94%	144.99	381 / 406
ovary	100%	14459.21	180 / 180	87%	93.88	374 / 430
pancreas	84%	4684.61	274 / 328	98%	214.39	174 / 178
adipose	100%	21925.30	1204 / 1204	0%	0	0 / 0
blood vessel	100%	24389.55	1335 / 1335	0%	0	0 / 0
muscle	100%	13186.22	802 / 803	0%	0	0 / 0
spleen	100%	8621.18	240 / 241	0%	0	0 / 0
heart	94%	10497.19	813 / 861	0%	0	0 / 0
tonsil	0%	0	0 / 0	89%	129.77	40 / 45
peripheral blood	88%	8063.20	820 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	86%	145.89	69 / 80
lymph node	0%	0	0 / 0	76%	83.27	22 / 29
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_1904219	Biological process	positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity
GO_0006658	Biological process	phosphatidylserine metabolic process
GO_0008654	Biological process	phospholipid biosynthetic process
GO_0044091	Biological process	membrane biogenesis
GO_1904222	Biological process	positive regulation of serine C-palmitoyltransferase activity
GO_0006665	Biological process	sphingolipid metabolic process
GO_0005886	Cellular component	plasma membrane
GO_0016020	Cellular component	membrane
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0030674	Molecular function	protein-macromolecule adaptor activity
GO_0005515	Molecular function	protein binding

Gene name	SERINC1
Protein name	Serine incorporator 1 (Tumor differentially expressed protein 1-like) (Tumor differentially expressed protein 2)
Synonyms	KIAA1253 UNQ396/PRO732 TDE2 TDE1L
Description	FUNCTION: Enhances the incorporation of serine into phosphatidylserine and sphingolipids. .
Accessions	ENST00000339697.5 Q9NRX5

SERINC1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review