SELENOS report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045454Biological processcell redox homeostasis
GO_0030970Biological processretrograde protein transport, ER to cytosol
GO_0098869Biological processcellular oxidant detoxification
GO_0032869Biological processcellular response to insulin stimulus
GO_2000110Biological processnegative regulation of macrophage apoptotic process
GO_1902236Biological processnegative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO_0009749Biological processresponse to glucose
GO_0032715Biological processnegative regulation of interleukin-6 production
GO_0080164Biological processregulation of nitric oxide metabolic process
GO_0045184Biological processestablishment of protein localization
GO_0006983Biological processER overload response
GO_0051771Biological processnegative regulation of nitric-oxide synthase biosynthetic process
GO_0006111Biological processregulation of gluconeogenesis
GO_0030968Biological processendoplasmic reticulum unfolded protein response
GO_0002865Biological processnegative regulation of acute inflammatory response to antigenic stimulus
GO_0034599Biological processcellular response to oxidative stress
GO_0050728Biological processnegative regulation of inflammatory response
GO_0051775Biological processresponse to redox state
GO_0071222Biological processcellular response to lipopolysaccharide
GO_0045719Biological processnegative regulation of glycogen biosynthetic process
GO_0032720Biological processnegative regulation of tumor necrosis factor production
GO_0036503Biological processERAD pathway
GO_0046325Biological processnegative regulation of glucose import
GO_0005886Cellular componentplasma membrane
GO_0036502Cellular componentDerlin-1-VIMP complex
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0034362Cellular componentlow-density lipoprotein particle
GO_0005783Cellular componentendoplasmic reticulum
GO_0005881Cellular componentcytoplasmic microtubule
GO_0034361Cellular componentvery-low-density lipoprotein particle
GO_0036513Cellular componentDerlin-1 retrotranslocation complex
GO_0019899Molecular functionenzyme binding
GO_1990381Molecular functionubiquitin-specific protease binding
GO_0038023Molecular functionsignaling receptor activity
GO_0016209Molecular functionantioxidant activity
GO_0051117Molecular functionATPase binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSELENOS
Protein nameSelenoprotein S (SelS) (VCP-interacting membrane protein)
Selenoprotein S
SynonymsSELS
VIMP
SBBI8
AD-015
DescriptionFUNCTION: Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination. .

FUNCTION: Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination. .

FUNCTION: Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination. .

AccessionsENST00000398226.7
ENST00000531964.5
E9PN30
ENST00000528346.1
ENST00000526049.6
Q9BQE4
A0A182DWI4