SEC11C | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
plasma cell	29 studies	75% ± 21%	Explore
natural killer cell	26 studies	23% ± 7%	Explore
B cell	24 studies	27% ± 17%	Explore
CD8-positive, alpha-beta T cell	21 studies	29% ± 13%	Explore
regulatory T cell	20 studies	33% ± 11%	Explore
plasmacytoid dendritic cell	19 studies	44% ± 9%	Explore
CD4-positive, alpha-beta T cell	19 studies	30% ± 14%	Explore
memory B cell	14 studies	23% ± 7%	Explore
T cell	13 studies	24% ± 6%	Explore
CD16-positive, CD56-dim natural killer cell, human	13 studies	23% ± 5%	Explore
mature NK T cell	13 studies	23% ± 6%	Explore
endothelial cell	13 studies	24% ± 10%	Explore
gamma-delta T cell	13 studies	26% ± 8%	Explore
plasmablast	12 studies	75% ± 25%	Explore
ciliated cell	12 studies	35% ± 15%	Explore
macrophage	11 studies	24% ± 10%	Explore
mucosal invariant T cell	11 studies	27% ± 6%	Explore
CD8-positive, alpha-beta memory T cell	10 studies	25% ± 5%	Explore
epithelial cell	10 studies	46% ± 21%	Explore
IgG plasma cell	10 studies	65% ± 18%	Explore
CD4-positive, alpha-beta memory T cell	9 studies	30% ± 11%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	9 studies	21% ± 5%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	9 studies	24% ± 7%	Explore
CD16-negative, CD56-bright natural killer cell, human	9 studies	24% ± 5%	Explore
IgA plasma cell	9 studies	69% ± 20%	Explore
endothelial cell of artery	9 studies	20% ± 4%	Explore
goblet cell	8 studies	25% ± 14%	Explore
abnormal cell	8 studies	35% ± 19%	Explore
astrocyte	8 studies	41% ± 22%	Explore
basal cell	7 studies	25% ± 12%	Explore
club cell	7 studies	26% ± 13%	Explore
secretory cell	7 studies	25% ± 9%	Explore
non-classical monocyte	7 studies	28% ± 10%	Explore
conventional dendritic cell	7 studies	29% ± 10%	Explore
effector memory CD8-positive, alpha-beta T cell	7 studies	26% ± 7%	Explore
neuron	7 studies	45% ± 23%	Explore
type II pneumocyte	6 studies	44% ± 21%	Explore
ionocyte	6 studies	66% ± 20%	Explore
respiratory goblet cell	6 studies	29% ± 18%	Explore
classical monocyte	6 studies	25% ± 8%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	37% ± 13%	Explore
naive B cell	6 studies	21% ± 6%	Explore
mast cell	6 studies	19% ± 4%	Explore
kidney loop of Henle epithelial cell	5 studies	25% ± 8%	Explore
enteroendocrine cell	5 studies	45% ± 22%	Explore
neuroendocrine cell	5 studies	85% ± 27%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	35% ± 15%	Explore
pancreatic A cell	4 studies	79% ± 7%	Explore
type B pancreatic cell	4 studies	88% ± 7%	Explore
exhausted T cell	4 studies	35% ± 6%	Explore
hematopoietic precursor cell	4 studies	25% ± 3%	Explore
retinal ganglion cell	4 studies	43% ± 26%	Explore
brush cell	4 studies	36% ± 15%	Explore
amacrine cell	4 studies	34% ± 16%	Explore
retina horizontal cell	4 studies	36% ± 14%	Explore
Mueller cell	4 studies	50% ± 21%	Explore
oligodendrocyte	4 studies	33% ± 14%	Explore
T follicular helper cell	4 studies	30% ± 7%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	42% ± 12%	Explore
innate lymphoid cell	4 studies	20% ± 2%	Explore
luminal cell of prostate epithelium	4 studies	47% ± 16%	Explore
IgM plasma cell	4 studies	59% ± 12%	Explore
GABAergic neuron	4 studies	27% ± 5%	Explore
glutamatergic neuron	4 studies	35% ± 7%	Explore
dendritic cell	4 studies	37% ± 18%	Explore
oligodendrocyte precursor cell	4 studies	30% ± 6%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	25% ± 6%	Explore
alveolar macrophage	3 studies	16% ± 0%	Explore
duct epithelial cell	3 studies	44% ± 4%	Explore
pancreatic D cell	3 studies	98% ± 3%	Explore
leukocyte	3 studies	30% ± 9%	Explore
myeloid cell	3 studies	27% ± 9%	Explore
retinal cone cell	3 studies	56% ± 12%	Explore
retinal rod cell	3 studies	34% ± 11%	Explore
acinar cell	3 studies	38% ± 14%	Explore
germinal center B cell	3 studies	20% ± 2%	Explore
endothelial cell of vascular tree	3 studies	20% ± 1%	Explore
intermediate monocyte	3 studies	32% ± 15%	Explore
CD4-positive helper T cell	3 studies	21% ± 4%	Explore
luminal hormone-sensing cell of mammary gland	3 studies	18% ± 2%	Explore
T-helper 17 cell	3 studies	42% ± 24%	Explore
interneuron	3 studies	26% ± 7%	Explore
T-helper 1 cell	3 studies	36% ± 18%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	32% ± 10%	Explore
erythroblast	3 studies	29% ± 8%	Explore
double negative thymocyte	3 studies	30% ± 4%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	15 studies	23% ± 6%	Explore
lung	11 studies	25% ± 9%	Explore
brain	9 studies	24% ± 6%	Explore
intestine	7 studies	25% ± 12%	Explore
eye	6 studies	33% ± 13%	Explore
liver	6 studies	21% ± 6%	Explore
kidney	5 studies	22% ± 3%	Explore
pancreas	4 studies	72% ± 14%	Explore
bone marrow	3 studies	33% ± 21%	Explore
uterus	3 studies	25% ± 12%	Explore
lymph node	3 studies	43% ± 21%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	3907.54	2642 / 2642	100%	73.20	705 / 705
prostate	100%	5246.14	245 / 245	100%	227.63	502 / 502
liver	100%	4035.72	226 / 226	100%	77.35	405 / 406
thymus	100%	3560.20	653 / 653	100%	53.89	603 / 605
breast	98%	1364.21	452 / 459	99%	46.33	1106 / 1118
pancreas	100%	5360.07	328 / 328	97%	41.58	173 / 178
stomach	100%	2262.55	358 / 359	97%	30.68	278 / 286
intestine	100%	1826.78	966 / 966	96%	32.97	508 / 527
lung	97%	1812.75	560 / 578	99%	57.68	1142 / 1155
uterus	98%	1419.14	166 / 170	98%	33.02	448 / 459
kidney	100%	2123.49	89 / 89	95%	34.75	856 / 901
adrenal gland	100%	2576.87	258 / 258	94%	56.86	216 / 230
skin	95%	1229.35	1719 / 1809	98%	68.65	464 / 472
bladder	100%	1090.67	21 / 21	93%	33.49	470 / 504
ovary	98%	1050.37	177 / 180	81%	18.05	350 / 430
esophagus	98%	1171.30	1416 / 1445	79%	18.15	144 / 183
lymph node	0%	0	0 / 0	100%	100.23	29 / 29
spleen	100%	3897.82	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	36.59	45 / 45
blood vessel	99%	1394.17	1317 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	98%	48.74	78 / 80
adipose	96%	938.53	1152 / 1204	0%	0	0 / 0
heart	75%	647.74	645 / 861	0%	0	0 / 0
peripheral blood	43%	1335.00	401 / 929	0%	0	0 / 0
muscle	33%	229.30	265 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

IV. Literature review

[source]

Gene name	SEC11C
Protein name	Signal peptidase complex catalytic subunit SEC11C (EC 3.4.21.89) (Microsomal signal peptidase 21 kDa subunit) (SPase 21 kDa subunit) (SEC11 homolog C) (SEC11-like protein 3) (SPC21) Signal peptidase complex catalytic subunit SEC11 (EC 3.4.21.89) SEC11 homolog C, signal peptidase complex subunit
Synonyms	SPC21 SPCS4C hCG_33729 SEC11L3
Description	FUNCTION: Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum . Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids . .
Accessions	K7EJQ7 A0A0A0MR04 ENST00000299714.7 ENST00000588875.2 B4DI03 ENST00000587834.6 Q9BY50 ENST00000509791.7

GO_0006465	Biological process	signal peptide processing
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0005787	Cellular component	signal peptidase complex
GO_0008233	Molecular function	peptidase activity
GO_0005515	Molecular function	protein binding
GO_0004252	Molecular function	serine-type endopeptidase activity

SEC11C report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review