RNF213 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0120323Biological processlipid ubiquitination
GO_0002376Biological processimmune system process
GO_0016567Biological processprotein ubiquitination
GO_0001525Biological processangiogenesis
GO_0098792Biological processxenophagy
GO_0051865Biological processprotein autoubiquitination
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0140042Biological processlipid droplet formation
GO_0019216Biological processregulation of lipid metabolic process
GO_2000051Biological processnegative regulation of non-canonical Wnt signaling pathway
GO_0002040Biological processsprouting angiogenesis
GO_0070534Biological processprotein K63-linked ubiquitination
GO_0042742Biological processdefense response to bacterium
GO_0005730Cellular componentnucleolus
GO_0005811Cellular componentlipid droplet
GO_0016020Cellular componentmembrane
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0046872Molecular functionmetal ion binding
GO_0005524Molecular functionATP binding
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0016887Molecular functionATP hydrolysis activity

IV. Literature review

[source]
Gene nameRNF213
Protein nameRing finger protein 213
E3 ubiquitin-protein ligase RNF213 (EC 2.3.2.27) (EC 3.6.4.-) (ALK lymphoma oligomerization partner on chromosome 17) (E3 ubiquitin-lipopolysaccharide ligase RNF213) (EC 2.3.2.-) (Mysterin) (RING finger protein 213)
SynonymsALO17
KIAA1554
C17orf27
MYSTR
KIAA1618
DescriptionFUNCTION: Atypical E3 ubiquitin ligase that can catalyze ubiquitination of both proteins and lipids, and which is involved in various processes, such as lipid metabolism, angiogenesis and cell-autonomous immunity . Acts as a key immune sensor by catalyzing ubiquitination of the lipid A moiety of bacterial lipopolysaccharide (LPS) via its RZ-type zinc-finger: restricts the proliferation of cytosolic bacteria, such as Salmonella, by generating the bacterial ubiquitin coat through the ubiquitination of LPS . Also acts indirectly by mediating the recruitment of the LUBAC complex, which conjugates linear polyubiquitin chains . Ubiquitination of LPS triggers cell-autonomous immunity, such as antibacterial autophagy, leading to degradation of the microbial invader . Involved in lipid metabolism by regulating fat storage and lipid droplet formation; act by inhibiting the lipolytic process . Also regulates lipotoxicity by inhibiting desaturation of fatty acids . Also acts as an E3 ubiquitin-protein ligase via its RING-type zinc finger: mediates 'Lys-63'-linked ubiquitination of target proteins . Involved in the non-canonical Wnt signaling pathway in vascular development: acts by mediating ubiquitination and degradation of FLNA and NFATC2 downstream of RSPO3, leading to inhibit the non-canonical Wnt signaling pathway and promoting vessel regression . Also has ATPase activity; ATPase activity is required for ubiquitination of LPS . .

AccessionsENST00000508628.6
A0A0A0MTR7
Q63HN8
ENST00000319921.4 [Q63HN8-5]
ENST00000573038.1
ENST00000582970.6
A0A0A0MTC1
I3L3H9