RAB8A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0060271Biological processcilium assembly
GO_0061512Biological processprotein localization to cilium
GO_0072659Biological processprotein localization to plasma membrane
GO_0048169Biological processregulation of long-term neuronal synaptic plasticity
GO_0032869Biological processcellular response to insulin stimulus
GO_0048210Biological processGolgi vesicle fusion to target membrane
GO_0032456Biological processendocytic recycling
GO_0009306Biological processprotein secretion
GO_0051223Biological processregulation of protein transport
GO_0007409Biological processaxonogenesis
GO_0007030Biological processGolgi organization
GO_0006904Biological processvesicle docking involved in exocytosis
GO_0098887Biological processneurotransmitter receptor transport, endosome to postsynaptic membrane
GO_0006887Biological processexocytosis
GO_0010506Biological processregulation of autophagy
GO_0099003Biological processvesicle-mediated transport in synapse
GO_0006914Biological processautophagy
GO_0098969Biological processneurotransmitter receptor transport to postsynaptic membrane
GO_0098978Cellular componentglutamatergic synapse
GO_0030496Cellular componentmidbody
GO_0005886Cellular componentplasma membrane
GO_0043197Cellular componentdendritic spine
GO_0005813Cellular componentcentrosome
GO_0070062Cellular componentextracellular exosome
GO_0055038Cellular componentrecycling endosome membrane
GO_0043025Cellular componentneuronal cell body
GO_0005814Cellular componentcentriole
GO_0060170Cellular componentciliary membrane
GO_0032588Cellular componenttrans-Golgi network membrane
GO_0000139Cellular componentGolgi membrane
GO_0097730Cellular componentnon-motile cilium
GO_0005929Cellular componentcilium
GO_0005829Cellular componentcytosol
GO_0008021Cellular componentsynaptic vesicle
GO_0045335Cellular componentphagocytic vesicle
GO_0014069Cellular componentpostsynaptic density
GO_0030140Cellular componenttrans-Golgi network transport vesicle
GO_0097546Cellular componentciliary base
GO_0030670Cellular componentphagocytic vesicle membrane
GO_0010008Cellular componentendosome membrane
GO_0036064Cellular componentciliary basal body
GO_0005768Cellular componentendosome
GO_0019003Molecular functionGDP binding
GO_0031267Molecular functionsmall GTPase binding
GO_1990782Molecular functionprotein tyrosine kinase binding
GO_0005525Molecular functionGTP binding
GO_0031489Molecular functionmyosin V binding
GO_0005515Molecular functionprotein binding
GO_0003924Molecular functionGTPase activity

IV. Literature review

[source]
Gene nameRAB8A
Protein nameRas-related protein Rab-8A (EC 3.6.5.2) (Oncogene c-mel)
SynonymsMEL
RAB8
DescriptionFUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in polarized vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis . Regulates the compacted morphology of the Golgi . Together with MYO5B and RAB11A participates in epithelial cell polarization . Also involved in membrane trafficking to the cilium and ciliogenesis . Together with MICALL2, may also regulate adherens junction assembly (By similarity). May play a role in insulin-induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore play a role in glucose homeostasis (By similarity). Involved in autophagy . Participates in the export of a subset of neosynthesized proteins through a Rab8-Rab10-Rab11-dependent endososomal export route . .

AccessionsP61006
ENST00000300935.8 [P61006-1]
ENST00000586682.1 [P61006-2]