PSMB9 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	40 studies	46% ± 16%	Explore
natural killer cell	40 studies	55% ± 16%	Explore
CD8-positive, alpha-beta T cell	37 studies	55% ± 20%	Explore
CD4-positive, alpha-beta T cell	33 studies	45% ± 19%	Explore
T cell	31 studies	46% ± 20%	Explore
regulatory T cell	26 studies	52% ± 20%	Explore
conventional dendritic cell	25 studies	51% ± 18%	Explore
endothelial cell	24 studies	40% ± 15%	Explore
non-classical monocyte	24 studies	62% ± 19%	Explore
classical monocyte	23 studies	40% ± 16%	Explore
mature NK T cell	22 studies	52% ± 16%	Explore
dendritic cell	20 studies	46% ± 22%	Explore
memory B cell	20 studies	52% ± 16%	Explore
gamma-delta T cell	19 studies	49% ± 15%	Explore
naive B cell	19 studies	41% ± 14%	Explore
macrophage	19 studies	37% ± 12%	Explore
monocyte	18 studies	39% ± 18%	Explore
plasmacytoid dendritic cell	18 studies	41% ± 17%	Explore
mucosal invariant T cell	16 studies	47% ± 15%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	16 studies	37% ± 13%	Explore
CD16-positive, CD56-dim natural killer cell, human	16 studies	58% ± 18%	Explore
endothelial cell of lymphatic vessel	15 studies	29% ± 9%	Explore
CD16-negative, CD56-bright natural killer cell, human	15 studies	54% ± 17%	Explore
plasma cell	15 studies	47% ± 18%	Explore
capillary endothelial cell	14 studies	36% ± 12%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	13 studies	52% ± 17%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	54% ± 24%	Explore
ciliated cell	12 studies	27% ± 9%	Explore
fibroblast	12 studies	25% ± 7%	Explore
effector memory CD8-positive, alpha-beta T cell	11 studies	50% ± 22%	Explore
plasmablast	11 studies	54% ± 22%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	49% ± 23%	Explore
endothelial cell of artery	10 studies	35% ± 11%	Explore
vein endothelial cell	9 studies	30% ± 8%	Explore
innate lymphoid cell	8 studies	37% ± 18%	Explore
endothelial cell of vascular tree	8 studies	39% ± 9%	Explore
mast cell	7 studies	19% ± 5%	Explore
epithelial cell	7 studies	34% ± 13%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	69% ± 25%	Explore
abnormal cell	7 studies	40% ± 21%	Explore
myeloid cell	7 studies	43% ± 15%	Explore
T follicular helper cell	7 studies	45% ± 10%	Explore
basal cell	6 studies	33% ± 15%	Explore
platelet	6 studies	23% ± 6%	Explore
precursor B cell	6 studies	47% ± 14%	Explore
CD4-positive helper T cell	5 studies	31% ± 11%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	60% ± 13%	Explore
exhausted T cell	5 studies	80% ± 7%	Explore
secretory cell	5 studies	28% ± 11%	Explore
effector CD4-positive, alpha-beta T cell	5 studies	75% ± 24%	Explore
leukocyte	5 studies	39% ± 15%	Explore
mononuclear phagocyte	5 studies	41% ± 21%	Explore
lymphocyte	5 studies	35% ± 22%	Explore
pro-B cell	5 studies	49% ± 15%	Explore
immature B cell	5 studies	50% ± 12%	Explore
double negative thymocyte	5 studies	58% ± 14%	Explore
intermediate monocyte	5 studies	57% ± 21%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	62% ± 18%	Explore
alveolar macrophage	4 studies	24% ± 4%	Explore
central memory CD8-positive, alpha-beta T cell	4 studies	49% ± 19%	Explore
club cell	4 studies	22% ± 2%	Explore
neutrophil	4 studies	31% ± 7%	Explore
respiratory goblet cell	4 studies	28% ± 13%	Explore
glomerular endothelial cell	4 studies	54% ± 8%	Explore
goblet cell	4 studies	25% ± 8%	Explore
transit amplifying cell	4 studies	28% ± 10%	Explore
hematopoietic stem cell	4 studies	33% ± 15%	Explore
enterocyte	4 studies	29% ± 5%	Explore
T-helper 17 cell	4 studies	55% ± 24%	Explore
T-helper 1 cell	4 studies	62% ± 15%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	69% ± 18%	Explore
hematopoietic precursor cell	3 studies	49% ± 23%	Explore
deuterosomal cell	3 studies	21% ± 8%	Explore
pericyte	3 studies	26% ± 10%	Explore
smooth muscle cell	3 studies	23% ± 5%	Explore
intraepithelial lymphocyte	3 studies	49% ± 5%	Explore
germinal center B cell	3 studies	48% ± 5%	Explore
brush cell	3 studies	23% ± 7%	Explore
connective tissue cell	3 studies	33% ± 6%	Explore
group 3 innate lymphoid cell	3 studies	32% ± 7%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	51% ± 16%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	20 studies	48% ± 14%	Explore
lung	14 studies	29% ± 9%	Explore
intestine	7 studies	24% ± 5%	Explore
lymph node	6 studies	34% ± 12%	Explore
bone marrow	4 studies	29% ± 17%	Explore
kidney	3 studies	54% ± 14%	Explore
brain	3 studies	20% ± 1%	Explore
liver	3 studies	40% ± 17%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
intestine	99%	1263.60	961 / 966	98%	87.67	516 / 527
lung	100%	1971.93	577 / 578	94%	64.40	1085 / 1155
kidney	100%	1088.29	89 / 89	92%	58.77	833 / 901
uterus	100%	979.55	170 / 170	91%	103.20	418 / 459
esophagus	96%	660.28	1394 / 1445	92%	56.52	169 / 183
ovary	99%	555.22	179 / 180	88%	55.81	378 / 430
stomach	90%	653.75	322 / 359	97%	77.63	278 / 286
thymus	99%	966.61	647 / 653	85%	46.95	514 / 605
skin	98%	719.33	1780 / 1809	85%	64.90	402 / 472
breast	100%	1297.97	459 / 459	84%	40.16	934 / 1118
liver	96%	615.53	217 / 226	83%	40.60	336 / 406
bladder	95%	737.81	20 / 21	79%	75.24	396 / 504
prostate	100%	879.64	244 / 245	72%	21.89	363 / 502
adrenal gland	100%	943.53	257 / 258	54%	15.88	124 / 230
brain	65%	320.60	1726 / 2642	75%	31.05	532 / 705
pancreas	33%	139.51	108 / 328	93%	54.85	165 / 178
lymph node	0%	0	0 / 0	100%	313.62	29 / 29
spleen	100%	5010.15	241 / 241	0%	0	0 / 0
adipose	100%	1451.50	1203 / 1204	0%	0	0 / 0
peripheral blood	100%	6176.50	928 / 929	0%	0	0 / 0
tonsil	0%	0	0 / 0	98%	137.42	44 / 45
heart	92%	481.68	792 / 861	0%	0	0 / 0
blood vessel	87%	565.04	1164 / 1335	0%	0	0 / 0
muscle	37%	128.19	300 / 803	0%	0	0 / 0
eye	0%	0	0 / 0	33%	27.98	26 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0002376	Biological process	immune system process
GO_2000116	Biological process	regulation of cysteine-type endopeptidase activity
GO_0043161	Biological process	proteasome-mediated ubiquitin-dependent protein catabolic process
GO_0000502	Cellular component	proteasome complex
GO_0070062	Cellular component	extracellular exosome
GO_0005839	Cellular component	proteasome core complex
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0019774	Cellular component	proteasome core complex, beta-subunit complex
GO_1990111	Cellular component	spermatoproteasome complex
GO_0005634	Cellular component	nucleus
GO_0004175	Molecular function	endopeptidase activity
GO_0005515	Molecular function	protein binding
GO_0004298	Molecular function	threonine-type endopeptidase activity

IV. Literature review

[source]

Gene name	PSMB9
Protein name	Proteasome subunit beta Proteasome subunit beta type-9 (EC 3.4.25.1) (Low molecular mass protein 2) (Macropain chain 7) (Multicatalytic endopeptidase complex chain 7) (Proteasome chain 7) (Proteasome subunit beta-1i) (Really interesting new gene 12 protein) Proteasome subunit beta type-9 proteasome endopeptidase complex (EC 3.4.25.1)
Synonyms	hCG_17510 LMP2 PSMB6i RING12
Description	FUNCTION: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Replacement of PSMB6 by PSMB9 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues. . FUNCTION: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. . FUNCTION: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. .
Accessions	ENST00000445315.2 ENST00000427870.6 A0A0G2JJQ0 ENST00000439630.5 ENST00000415658.5 ENST00000399381.3 ENST00000414474.5 ENST00000420182.5 ENST00000448066.2 A0A0G2JHI2 A2ACR0 ENST00000417566.5 ENST00000422904.5 ENST00000395330.5 ENST00000383114.8 [P28065-1] P28065 ENST00000399607.5 ENST00000434471.6 A0A0G2JJA7 ENST00000425855.2 ENST00000423563.2 ENST00000399619.3 ENST00000444284.6 [P28065-1] ENST00000413480.5 A0A0G2JJ13 ENST00000374859.3 [P28065-1] ENST00000422729.6 [P28065-1] ENST00000453059.6 ENST00000451862.5 A2ACR1 ENST00000418861.2 ENST00000399371.5 ENST00000434083.5 ENST00000434587.5 ENST00000419512.5 ENST00000383234.8 [P28065-1] ENST00000438515.5 ENST00000455846.5

PSMB9 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review