PPP2R1A | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	24 studies	28% ± 10%	Explore
endothelial cell	24 studies	31% ± 13%	Explore
CD8-positive, alpha-beta T cell	21 studies	29% ± 8%	Explore
fibroblast	21 studies	34% ± 16%	Explore
B cell	19 studies	29% ± 10%	Explore
pericyte	19 studies	31% ± 16%	Explore
smooth muscle cell	19 studies	30% ± 14%	Explore
CD4-positive, alpha-beta T cell	18 studies	28% ± 9%	Explore
regulatory T cell	18 studies	32% ± 8%	Explore
memory B cell	15 studies	27% ± 9%	Explore
epithelial cell	15 studies	40% ± 21%	Explore
classical monocyte	14 studies	25% ± 10%	Explore
macrophage	14 studies	24% ± 8%	Explore
T cell	13 studies	29% ± 12%	Explore
ciliated cell	13 studies	34% ± 16%	Explore
non-classical monocyte	13 studies	29% ± 10%	Explore
naive B cell	13 studies	26% ± 6%	Explore
CD16-positive, CD56-dim natural killer cell, human	12 studies	31% ± 12%	Explore
basal cell	11 studies	33% ± 17%	Explore
CD16-negative, CD56-bright natural killer cell, human	11 studies	32% ± 11%	Explore
mature NK T cell	11 studies	32% ± 11%	Explore
connective tissue cell	11 studies	43% ± 20%	Explore
endothelial cell of lymphatic vessel	11 studies	35% ± 17%	Explore
gamma-delta T cell	11 studies	30% ± 11%	Explore
conventional dendritic cell	10 studies	33% ± 15%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	10 studies	24% ± 6%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	10 studies	27% ± 5%	Explore
abnormal cell	10 studies	30% ± 15%	Explore
glutamatergic neuron	10 studies	34% ± 16%	Explore
CD8-positive, alpha-beta memory T cell	9 studies	28% ± 11%	Explore
monocyte	9 studies	20% ± 6%	Explore
myofibroblast cell	9 studies	44% ± 14%	Explore
mucosal invariant T cell	9 studies	27% ± 5%	Explore
plasmacytoid dendritic cell	9 studies	26% ± 8%	Explore
CD4-positive, alpha-beta memory T cell	8 studies	29% ± 8%	Explore
neuron	8 studies	47% ± 24%	Explore
goblet cell	8 studies	25% ± 11%	Explore
endothelial cell of artery	7 studies	26% ± 15%	Explore
GABAergic neuron	7 studies	35% ± 15%	Explore
dendritic cell	7 studies	35% ± 15%	Explore
plasmablast	6 studies	40% ± 22%	Explore
effector memory CD8-positive, alpha-beta T cell	6 studies	29% ± 7%	Explore
capillary endothelial cell	6 studies	30% ± 19%	Explore
vein endothelial cell	6 studies	29% ± 14%	Explore
precursor B cell	6 studies	38% ± 12%	Explore
endothelial cell of vascular tree	6 studies	24% ± 4%	Explore
T follicular helper cell	6 studies	24% ± 5%	Explore
oligodendrocyte	6 studies	18% ± 3%	Explore
type I pneumocyte	5 studies	33% ± 15%	Explore
plasma cell	5 studies	34% ± 13%	Explore
kidney loop of Henle epithelial cell	5 studies	27% ± 11%	Explore
progenitor cell	5 studies	41% ± 14%	Explore
enterocyte	5 studies	22% ± 5%	Explore
enteroendocrine cell	5 studies	41% ± 16%	Explore
transit amplifying cell	5 studies	22% ± 3%	Explore
astrocyte	5 studies	26% ± 12%	Explore
effector CD8-positive, alpha-beta T cell	5 studies	34% ± 13%	Explore
oligodendrocyte precursor cell	5 studies	37% ± 14%	Explore
hematopoietic precursor cell	4 studies	36% ± 11%	Explore
secretory cell	4 studies	29% ± 8%	Explore
pancreatic A cell	4 studies	42% ± 14%	Explore
exhausted T cell	4 studies	35% ± 4%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	52% ± 14%	Explore
epithelial cell of proximal tubule	4 studies	33% ± 17%	Explore
intestinal crypt stem cell	4 studies	24% ± 6%	Explore
mesothelial cell	4 studies	63% ± 17%	Explore
retinal ganglion cell	4 studies	83% ± 22%	Explore
hematopoietic stem cell	4 studies	33% ± 13%	Explore
pro-B cell	4 studies	42% ± 12%	Explore
myeloid cell	4 studies	26% ± 10%	Explore
brush cell	4 studies	26% ± 7%	Explore
club cell	4 studies	31% ± 9%	Explore
amacrine cell	4 studies	43% ± 18%	Explore
retina horizontal cell	4 studies	39% ± 18%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	43% ± 6%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	33% ± 6%	Explore
interneuron	4 studies	34% ± 16%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	27% ± 9%	Explore
precursor cell	3 studies	53% ± 25%	Explore
respiratory goblet cell	3 studies	32% ± 22%	Explore
squamous epithelial cell	3 studies	39% ± 23%	Explore
type B pancreatic cell	3 studies	42% ± 10%	Explore
glomerular endothelial cell	3 studies	17% ± 1%	Explore
renal alpha-intercalated cell	3 studies	42% ± 8%	Explore
neural crest cell	3 studies	40% ± 13%	Explore
retinal bipolar neuron	3 studies	40% ± 16%	Explore
GABAergic interneuron	3 studies	18% ± 1%	Explore
OFF-bipolar cell	3 studies	49% ± 31%	Explore
ON-bipolar cell	3 studies	48% ± 34%	Explore
common myeloid progenitor	3 studies	33% ± 22%	Explore
lymphocyte	3 studies	28% ± 7%	Explore
immature B cell	3 studies	40% ± 12%	Explore
type II pneumocyte	3 studies	40% ± 10%	Explore
Mueller cell	3 studies	22% ± 2%	Explore
germinal center B cell	3 studies	36% ± 10%	Explore
intermediate monocyte	3 studies	35% ± 17%	Explore
muscle cell	3 studies	31% ± 16%	Explore
pancreatic ductal cell	3 studies	54% ± 20%	Explore
group 3 innate lymphoid cell	3 studies	34% ± 12%	Explore
double negative thymocyte	3 studies	42% ± 10%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	13 studies	28% ± 6%	Explore
brain	12 studies	26% ± 8%	Explore
lung	10 studies	32% ± 14%	Explore
intestine	8 studies	28% ± 13%	Explore
kidney	7 studies	27% ± 10%	Explore
eye	5 studies	30% ± 10%	Explore
lymph node	4 studies	26% ± 5%	Explore
pancreas	3 studies	45% ± 5%	Explore
placenta	3 studies	27% ± 13%	Explore
bone marrow	3 studies	19% ± 4%	Explore
adrenal gland	3 studies	21% ± 7%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
adrenal gland	100%	29078.76	258 / 258	100%	195.53	230 / 230
esophagus	100%	16854.79	1445 / 1445	100%	103.75	183 / 183
ovary	100%	18949.81	180 / 180	100%	123.26	430 / 430
thymus	100%	14082.44	653 / 653	100%	163.96	605 / 605
skin	100%	15048.05	1808 / 1809	100%	144.36	472 / 472
brain	100%	21141.64	2640 / 2642	100%	160.20	705 / 705
uterus	100%	15650.68	170 / 170	100%	149.85	458 / 459
kidney	100%	15492.07	89 / 89	100%	124.17	899 / 901
stomach	100%	10300.27	359 / 359	100%	124.98	285 / 286
breast	100%	13259.28	459 / 459	100%	146.99	1114 / 1118
intestine	100%	14018.82	966 / 966	100%	141.95	525 / 527
bladder	100%	15360.48	21 / 21	99%	148.25	501 / 504
prostate	100%	14424.31	245 / 245	99%	167.87	499 / 502
liver	100%	5553.67	225 / 226	100%	79.73	404 / 406
lung	100%	11408.96	576 / 578	99%	111.37	1147 / 1155
pancreas	97%	6313.25	319 / 328	100%	121.95	178 / 178
adipose	100%	12539.35	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	181.38	80 / 80
lymph node	0%	0	0 / 0	100%	158.66	29 / 29
muscle	100%	17837.97	803 / 803	0%	0	0 / 0
spleen	100%	10498.90	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	123.32	45 / 45
ureter	0%	0	0 / 0	100%	90.54	1 / 1
blood vessel	100%	14949.57	1334 / 1335	0%	0	0 / 0
heart	99%	20874.58	850 / 861	0%	0	0 / 0
peripheral blood	92%	8782.26	857 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0043029	Biological process	T cell homeostasis
GO_0006470	Biological process	protein dephosphorylation
GO_0007059	Biological process	chromosome segregation
GO_0007143	Biological process	female meiotic nuclear division
GO_0065003	Biological process	protein-containing complex assembly
GO_0051754	Biological process	meiotic sister chromatid cohesion, centromeric
GO_0051898	Biological process	negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0035331	Biological process	negative regulation of hippo signaling
GO_0035556	Biological process	intracellular signal transduction
GO_0045595	Biological process	regulation of cell differentiation
GO_0051232	Biological process	meiotic spindle elongation
GO_2001241	Biological process	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO_0051306	Biological process	mitotic sister chromatid separation
GO_1903538	Biological process	regulation of meiotic cell cycle process involved in oocyte maturation
GO_0040008	Biological process	regulation of growth
GO_0000775	Cellular component	chromosome, centromeric region
GO_0098978	Cellular component	glutamatergic synapse
GO_0016020	Cellular component	membrane
GO_0005739	Cellular component	mitochondrion
GO_0090443	Cellular component	FAR/SIN/STRIPAK complex
GO_0070062	Cellular component	extracellular exosome
GO_0043025	Cellular component	neuronal cell body
GO_0043005	Cellular component	neuron projection
GO_0030425	Cellular component	dendrite
GO_0005829	Cellular component	cytosol
GO_0015630	Cellular component	microtubule cytoskeleton
GO_0016328	Cellular component	lateral plasma membrane
GO_0005737	Cellular component	cytoplasm
GO_0000159	Cellular component	protein phosphatase type 2A complex
GO_0005634	Cellular component	nucleus
GO_1990405	Molecular function	protein antigen binding
GO_0004722	Molecular function	protein serine/threonine phosphatase activity
GO_0046982	Molecular function	protein heterodimerization activity
GO_0019888	Molecular function	protein phosphatase regulator activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	PPP2R1A
Protein name	Protein phosphatase 2 scaffold subunit Aalpha (cDNA FLJ33169 fis, clone ADRGL2000384, highly similar to Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform) Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (Medium tumor antigen-associated 61 kDa protein) (PP2A subunit A isoform PR65-alpha) (PP2A subunit A isoform R1-alpha) Protein phosphatase 2 scaffold subunit Aalpha Protein phosphatase 2 (Formerly 2A), regulatory subunit A (PR 65), alpha isoform (Testicular secretory protein Li 1) (cDNA, FLJ96799, Homo sapiens protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform (PPP2R1A), mRNA)
Synonyms	hCG_19686
Description	FUNCTION: The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Upon interaction with GNA12 promotes dephosphorylation of microtubule associated protein TAU/MAPT . Required for proper chromosome segregation and for centromeric localization of SGO1 in mitosis . Together with RACK1 adapter, mediates dephosphorylation of AKT1 at 'Ser-473', preventing AKT1 activation and AKT-mTOR signaling pathway (By similarity). Dephosphorylation of AKT1 is essential for regulatory T-cells (Treg) homeostasis and stability (By similarity). .
Accessions	ENST00000477989.1 M0QXG4 A0A994J3N8 ENST00000703398.1 P30153 ENST00000322088.11 E9PH38 ENST00000391791.4 ENST00000703422.1 C9J9C1 B3KQV6 ENST00000490868.5 ENST00000703401.1 A8K7B7 ENST00000703423.1 A0A994J3H1 ENST00000454220.7 ENST00000703395.1 A0A994J6A3 M0R0K6 ENST00000462990.5 ENST00000703397.1

PPP2R1A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review