POLR2G | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	31 studies	31% ± 10%	Explore
B cell	22 studies	26% ± 9%	Explore
CD8-positive, alpha-beta T cell	19 studies	30% ± 9%	Explore
fibroblast	19 studies	29% ± 14%	Explore
CD4-positive, alpha-beta T cell	18 studies	26% ± 9%	Explore
T cell	17 studies	25% ± 9%	Explore
endothelial cell	17 studies	32% ± 15%	Explore
regulatory T cell	15 studies	25% ± 7%	Explore
conventional dendritic cell	14 studies	31% ± 16%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	32% ± 10%	Explore
classical monocyte	13 studies	25% ± 11%	Explore
macrophage	13 studies	25% ± 10%	Explore
mature NK T cell	12 studies	30% ± 10%	Explore
smooth muscle cell	12 studies	28% ± 9%	Explore
gamma-delta T cell	12 studies	28% ± 14%	Explore
non-classical monocyte	11 studies	30% ± 12%	Explore
CD16-negative, CD56-bright natural killer cell, human	11 studies	33% ± 8%	Explore
connective tissue cell	11 studies	34% ± 15%	Explore
pericyte	11 studies	31% ± 13%	Explore
plasmacytoid dendritic cell	11 studies	30% ± 11%	Explore
memory B cell	10 studies	22% ± 5%	Explore
naive B cell	10 studies	20% ± 6%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	10 studies	24% ± 6%	Explore
monocyte	9 studies	25% ± 7%	Explore
epithelial cell	9 studies	38% ± 20%	Explore
mucosal invariant T cell	9 studies	22% ± 4%	Explore
CD8-positive, alpha-beta memory T cell	8 studies	28% ± 12%	Explore
myofibroblast cell	8 studies	36% ± 6%	Explore
endothelial cell of lymphatic vessel	8 studies	30% ± 11%	Explore
CD4-positive, alpha-beta memory T cell	7 studies	25% ± 7%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	7 studies	19% ± 3%	Explore
dendritic cell	7 studies	33% ± 20%	Explore
abnormal cell	7 studies	25% ± 14%	Explore
basal cell	6 studies	34% ± 17%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	32% ± 10%	Explore
capillary endothelial cell	6 studies	24% ± 8%	Explore
precursor B cell	6 studies	38% ± 12%	Explore
endothelial cell of vascular tree	6 studies	22% ± 4%	Explore
ciliated cell	6 studies	31% ± 13%	Explore
T follicular helper cell	6 studies	21% ± 5%	Explore
hematopoietic precursor cell	5 studies	36% ± 22%	Explore
effector memory CD8-positive, alpha-beta T cell	5 studies	28% ± 4%	Explore
progenitor cell	5 studies	32% ± 7%	Explore
endothelial cell of artery	5 studies	23% ± 4%	Explore
mesothelial cell	5 studies	39% ± 19%	Explore
vein endothelial cell	5 studies	26% ± 8%	Explore
pro-B cell	5 studies	35% ± 9%	Explore
neuron	5 studies	34% ± 14%	Explore
leukocyte	4 studies	26% ± 8%	Explore
exhausted T cell	4 studies	37% ± 5%	Explore
epithelial cell of proximal tubule	4 studies	27% ± 15%	Explore
myeloid cell	4 studies	27% ± 11%	Explore
platelet	4 studies	22% ± 6%	Explore
immature B cell	4 studies	38% ± 18%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	32% ± 3%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	25% ± 6%	Explore
innate lymphoid cell	4 studies	24% ± 6%	Explore
enteroendocrine cell	4 studies	32% ± 18%	Explore
mast cell	4 studies	22% ± 6%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	23% ± 3%	Explore
pancreatic A cell	3 studies	32% ± 7%	Explore
type B pancreatic cell	3 studies	27% ± 9%	Explore
mononuclear phagocyte	3 studies	33% ± 16%	Explore
kidney loop of Henle epithelial cell	3 studies	18% ± 2%	Explore
neural crest cell	3 studies	38% ± 8%	Explore
type I pneumocyte	3 studies	32% ± 7%	Explore
type II pneumocyte	3 studies	30% ± 16%	Explore
retinal cone cell	3 studies	42% ± 20%	Explore
intraepithelial lymphocyte	3 studies	32% ± 12%	Explore
Mueller cell	3 studies	23% ± 5%	Explore
germinal center B cell	3 studies	32% ± 5%	Explore
goblet cell	3 studies	27% ± 12%	Explore
intestinal crypt stem cell	3 studies	22% ± 5%	Explore
group 3 innate lymphoid cell	3 studies	34% ± 14%	Explore
secretory cell	3 studies	29% ± 10%	Explore
T-helper 1 cell	3 studies	26% ± 5%	Explore
double negative thymocyte	3 studies	40% ± 21%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	13 studies	26% ± 8%	Explore
lung	8 studies	33% ± 13%	Explore
intestine	6 studies	26% ± 14%	Explore
kidney	5 studies	28% ± 6%	Explore
lymph node	5 studies	21% ± 3%	Explore
pancreas	4 studies	26% ± 9%	Explore
bone marrow	4 studies	19% ± 2%	Explore
eye	4 studies	28% ± 12%	Explore
adrenal gland	3 studies	20% ± 3%	Explore
liver	3 studies	31% ± 17%	Explore
thymus	3 studies	47% ± 22%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	2015.04	1445 / 1445	100%	75.21	183 / 183
ovary	100%	2065.82	180 / 180	100%	109.40	430 / 430
skin	100%	2535.04	1809 / 1809	100%	106.72	472 / 472
uterus	100%	2237.53	170 / 170	100%	122.02	459 / 459
brain	100%	2116.53	2641 / 2642	100%	161.58	705 / 705
thymus	100%	2120.10	653 / 653	100%	92.66	604 / 605
prostate	100%	2379.74	245 / 245	100%	100.43	501 / 502
liver	100%	1129.98	226 / 226	100%	61.63	405 / 406
lung	100%	2251.56	578 / 578	100%	100.85	1152 / 1155
kidney	100%	2278.81	89 / 89	100%	72.82	898 / 901
breast	100%	2552.85	459 / 459	99%	120.23	1112 / 1118
intestine	100%	2133.29	966 / 966	99%	92.01	524 / 527
pancreas	100%	1027.02	327 / 328	99%	81.14	177 / 178
stomach	100%	1672.46	359 / 359	99%	85.93	283 / 286
bladder	100%	2193.52	21 / 21	99%	119.99	498 / 504
adrenal gland	100%	2638.05	258 / 258	97%	63.54	224 / 230
adipose	100%	2433.85	1204 / 1204	0%	0	0 / 0
blood vessel	100%	2277.77	1335 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	100%	74.33	80 / 80
lymph node	0%	0	0 / 0	100%	182.08	29 / 29
spleen	100%	3147.52	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	106.94	45 / 45
ureter	0%	0	0 / 0	100%	89.07	1 / 1
peripheral blood	99%	2473.57	922 / 929	0%	0	0 / 0
heart	99%	1295.66	851 / 861	0%	0	0 / 0
muscle	99%	1094.05	793 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006366	Biological process	transcription by RNA polymerase II
GO_0006367	Biological process	transcription initiation at RNA polymerase II promoter
GO_0045948	Biological process	positive regulation of translational initiation
GO_0000956	Biological process	nuclear-transcribed mRNA catabolic process
GO_0060213	Biological process	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
GO_0000932	Cellular component	P-body
GO_0005665	Cellular component	RNA polymerase II, core complex
GO_0005654	Cellular component	nucleoplasm
GO_0005634	Cellular component	nucleus
GO_0031369	Molecular function	translation initiation factor binding
GO_0005515	Molecular function	protein binding
GO_0003697	Molecular function	single-stranded DNA binding
GO_0003727	Molecular function	single-stranded RNA binding

IV. Literature review

[source]

Gene name	POLR2G
Protein name	DNA-directed RNA polymerase II subunit RPB7 (RNA polymerase II subunit B7) (DNA-directed RNA polymerase II subunit G) (RNA polymerase II 19 kDa subunit) (RPB19) RNA polymerase II subunit G
Synonyms	RPB7
Description	FUNCTION: Core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. POLR2G/RPB7 is part of a subcomplex with POLR2D/RPB4 that binds to a pocket formed by POLR2A/RPB1, POLR2B/RPB2 and POLR2F/RPABC2 at the base of the clamp element. The POLR2D/RPB4-POLR2G/RPB7 subcomplex seems to lock the clamp via POLR2G/RPB7 in the closed conformation thus preventing double-stranded DNA to enter the active site cleft. The POLR2D/RPB4-POLR2G/RPB7 subcomplex binds single-stranded DNA and RNA. .
Accessions	H0YEE4 ENST00000531944.5 ENST00000301788.12 ENST00000524819.5 ENST00000533442.5 E9PIU7 ENST00000525455.5 E9PS03 P62487 E9PKH3 ENST00000531996.5

POLR2G report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review