PNKD report

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I. Expression across cell types

Cell ontologyData table

Name	Number of supported studies	Average coverage
endothelial cell	21 studies	26% ± 10%	Explore
fibroblast	21 studies	25% ± 10%	Explore
B cell	17 studies	23% ± 4%	Explore
ciliated cell	17 studies	39% ± 17%	Explore
epithelial cell	17 studies	35% ± 19%	Explore
macrophage	17 studies	21% ± 6%	Explore
pericyte	17 studies	23% ± 6%	Explore
natural killer cell	16 studies	22% ± 7%	Explore
smooth muscle cell	16 studies	25% ± 6%	Explore
CD8-positive, alpha-beta T cell	13 studies	21% ± 4%	Explore
classical monocyte	13 studies	25% ± 9%	Explore
basal cell	11 studies	34% ± 16%	Explore
monocyte	11 studies	18% ± 3%	Explore
connective tissue cell	11 studies	23% ± 6%	Explore
non-classical monocyte	10 studies	25% ± 11%	Explore
type II pneumocyte	9 studies	31% ± 14%	Explore
CD16-positive, CD56-dim natural killer cell, human	9 studies	22% ± 4%	Explore
T cell	9 studies	19% ± 6%	Explore
myofibroblast cell	9 studies	24% ± 5%	Explore
type I pneumocyte	8 studies	32% ± 12%	Explore
secretory cell	8 studies	29% ± 15%	Explore
CD16-negative, CD56-bright natural killer cell, human	8 studies	22% ± 4%	Explore
CD4-positive, alpha-beta T cell	8 studies	19% ± 3%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	8 studies	21% ± 3%	Explore
progenitor cell	8 studies	27% ± 11%	Explore
abnormal cell	8 studies	25% ± 7%	Explore
regulatory T cell	8 studies	20% ± 3%	Explore
endothelial cell of lymphatic vessel	8 studies	22% ± 8%	Explore
astrocyte	8 studies	31% ± 12%	Explore
club cell	7 studies	33% ± 6%	Explore
epithelial cell of proximal tubule	7 studies	29% ± 9%	Explore
endothelial cell of artery	7 studies	19% ± 2%	Explore
goblet cell	7 studies	27% ± 12%	Explore
memory B cell	7 studies	21% ± 5%	Explore
plasmacytoid dendritic cell	7 studies	21% ± 6%	Explore
gamma-delta T cell	7 studies	25% ± 15%	Explore
respiratory goblet cell	6 studies	29% ± 13%	Explore
mature NK T cell	6 studies	19% ± 2%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	6 studies	19% ± 3%	Explore
capillary endothelial cell	6 studies	20% ± 4%	Explore
kidney loop of Henle epithelial cell	6 studies	44% ± 10%	Explore
renal alpha-intercalated cell	6 studies	43% ± 12%	Explore
glutamatergic neuron	6 studies	35% ± 23%	Explore
hematopoietic stem cell	6 studies	23% ± 7%	Explore
hematopoietic precursor cell	5 studies	28% ± 9%	Explore
plasmablast	5 studies	42% ± 21%	Explore
CD4-positive, alpha-beta memory T cell	5 studies	19% ± 2%	Explore
ionocyte	5 studies	29% ± 12%	Explore
conventional dendritic cell	5 studies	30% ± 14%	Explore
effector memory CD8-positive, alpha-beta T cell	5 studies	22% ± 4%	Explore
enterocyte	5 studies	22% ± 3%	Explore
mesothelial cell	5 studies	31% ± 15%	Explore
myeloid cell	5 studies	25% ± 10%	Explore
platelet	5 studies	23% ± 6%	Explore
neuron	5 studies	40% ± 12%	Explore
oligodendrocyte precursor cell	5 studies	28% ± 11%	Explore
naive B cell	5 studies	22% ± 3%	Explore
plasma cell	4 studies	30% ± 12%	Explore
CD8-positive, alpha-beta memory T cell	4 studies	24% ± 9%	Explore
exhausted T cell	4 studies	23% ± 4%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	46% ± 13%	Explore
vein endothelial cell	4 studies	21% ± 8%	Explore
retinal ganglion cell	4 studies	54% ± 26%	Explore
megakaryocyte	4 studies	36% ± 10%	Explore
amacrine cell	4 studies	34% ± 14%	Explore
transit amplifying cell	4 studies	25% ± 7%	Explore
oligodendrocyte	4 studies	23% ± 7%	Explore
effector CD8-positive, alpha-beta T cell	4 studies	24% ± 3%	Explore
endothelial cell of vascular tree	4 studies	22% ± 5%	Explore
luminal cell of prostate epithelium	4 studies	23% ± 8%	Explore
GABAergic neuron	4 studies	40% ± 19%	Explore
mucosal invariant T cell	4 studies	20% ± 2%	Explore
deuterosomal cell	3 studies	20% ± 6%	Explore
duct epithelial cell	3 studies	29% ± 13%	Explore
glomerular endothelial cell	3 studies	18% ± 2%	Explore
intestinal crypt stem cell	3 studies	25% ± 11%	Explore
neural crest cell	3 studies	20% ± 1%	Explore
common myeloid progenitor	3 studies	31% ± 19%	Explore
pro-B cell	3 studies	24% ± 2%	Explore
retina horizontal cell	3 studies	31% ± 9%	Explore
serous secreting cell	3 studies	37% ± 12%	Explore
Mueller cell	3 studies	36% ± 10%	Explore
erythroblast	3 studies	32% ± 20%	Explore
T follicular helper cell	3 studies	19% ± 1%	Explore
germinal center B cell	3 studies	19% ± 2%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	20% ± 4%	Explore
intermediate monocyte	3 studies	32% ± 14%	Explore
adipocyte	3 studies	24% ± 7%	Explore
dendritic cell	3 studies	40% ± 9%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	19% ± 2%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	37% ± 23%	Explore
brush cell	3 studies	20% ± 5%	Explore
enteroendocrine cell	3 studies	39% ± 18%	Explore
double negative thymocyte	3 studies	31% ± 17%	Explore
interneuron	3 studies	30% ± 18%	Explore
luminal hormone-sensing cell of mammary gland	3 studies	27% ± 6%	Explore
hepatocyte	3 studies	48% ± 20%	Explore

II. Expression across tissues

sc-RNAseq dataData table

Name	Number of supported studies	Average coverage
lung	10 studies	32% ± 12%	Explore
peripheral blood	10 studies	24% ± 6%	Explore
kidney	9 studies	23% ± 6%	Explore
intestine	8 studies	24% ± 10%	Explore
eye	6 studies	24% ± 8%	Explore
brain	6 studies	32% ± 13%	Explore
uterus	4 studies	29% ± 18%	Explore
liver	4 studies	31% ± 17%	Explore
pancreas	3 studies	23% ± 4%	Explore
bone marrow	3 studies	17% ± 1%	Explore
thymus	3 studies	34% ± 12%	Explore

Bulk RNAseq dataData table

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
liver	100%	11232.22	226 / 226	100%	94.94	406 / 406
ovary	100%	1964.53	180 / 180	100%	110.34	430 / 430
prostate	100%	6122.45	245 / 245	100%	151.60	502 / 502
thymus	100%	5023.33	653 / 653	100%	57.93	605 / 605
brain	100%	5338.04	2641 / 2642	100%	45.51	705 / 705
skin	100%	1752.97	1803 / 1809	100%	57.93	472 / 472
stomach	100%	3974.16	359 / 359	100%	72.22	285 / 286
intestine	100%	3001.70	966 / 966	100%	68.61	525 / 527
lung	100%	4803.62	578 / 578	99%	64.95	1148 / 1155
bladder	100%	3049.57	21 / 21	98%	50.12	496 / 504
kidney	100%	5451.30	89 / 89	98%	43.26	885 / 901
breast	100%	2138.18	459 / 459	98%	45.89	1097 / 1118
uterus	100%	2034.66	170 / 170	98%	44.22	449 / 459
pancreas	98%	1573.85	321 / 328	99%	59.13	176 / 178
adrenal gland	100%	3876.24	258 / 258	97%	34.23	222 / 230
esophagus	99%	1698.47	1431 / 1445	93%	49.69	170 / 183
eye	0%	0	0 / 0	100%	54.25	80 / 80
lymph node	0%	0	0 / 0	100%	64.63	29 / 29
spleen	100%	3768.32	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	53.90	1 / 1
adipose	100%	2376.81	1203 / 1204	0%	0	0 / 0
blood vessel	99%	1935.29	1320 / 1335	0%	0	0 / 0
tonsil	0%	0	0 / 0	98%	35.73	44 / 45
peripheral blood	97%	1965.82	903 / 929	0%	0	0 / 0
heart	97%	2330.59	834 / 861	0%	0	0 / 0
muscle	93%	1194.70	746 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0